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A double‐blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome
Abstract
A double‐blind randomized crossover study of 7.5 mg bromocriptine at bedtime versus placebo was conducted in 30‐day phases (with a 2‐week washout period between phases) in 6 patients with idiopathic restless legs syndrome. Five patients experienced partial subjective improvement in restlessness and paresthesias on bromocriptine as opposed to placebo and expressed a desire to continue on the medication. On bromocriptine, the patients showed polysomnographically a mean Decemberrease of 43% from control and a mean Decemberrease of 57% from placebo in the number of periodic movements of sleep per hour of sleep (p < 0.025). Two of 3 patients with abnormally Decemberreased total sleep time and sleep efficiency showed an improvement in these measures on therapy. The dopamine agonist bromocriptine may be a useful therapy in some patients with restless legs syndrome.
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Cited by
Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology
Allen, R. P., Picchietti, D., Hening, W. A., Trenkwalder, C., Walters, A. S., & Montplaisi, J. (2003) · Sleep Medicine · doi:10.1016/s1389-9457(03)00010-8 · Cited by 2,900
Self-citationAugmentation of the Restless Legs Syndrome With Carbidopa/Levodopa
Allen, R. P., & Earley, C. J. (1996) · Sleep · doi:10.1093/sleep/19.3.205 · Cited by 451
Restless legs syndrome: Clinicoetiologic correlates
Ondo, W., & Jankovic, J. (1996) · Neurology · doi:10.1212/wnl.47.6.1435 · Cited by 317
Neurophysiology of sleep and wakefulness: basic science and clinical implications
Schwartz, J., & Roth, T. (2008) · Current Neuropharmacology · doi:10.2174/157015908787386050 · Cited by 289
EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep
Vignatelli, L., Billiard, M., Clarenbach, P., Garcia‐Borreguero, D., Kaynak, D., Liesiene, V., Trenkwalder, C., & Montagna, P. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01410.x · Cited by 144
Metadata
- Authors
- Walters, A. S., Hening, W. A., Kavey, N., Chokroverty, S., & Gidro‐Frank, S.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1988-09
- Volume
- 24
- Issue
- 3
- Pages
- 455-458
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2084833767
- Cited by
- 175
- References
- 0
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A double‐blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome. https://app.cochat.ai/papers/10.1002/ana.410240318
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- Walters, A. S., Hening, W. A., Kavey, N., Chokroverty, S., & Gidro‐Frank, S. (1988). A double‐blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome. Annals of Neurology. https://doi.org/10.1002/ana.410240318
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
