Cited by 570Restless Legs Syndrome ResearchNeurological diseases and metabolismAdvanced MRI Techniques and Applications

MRI measurement of brain iron in patients with restless legs syndrome

Allen, R.P., Barker, P.B., Wehrl, F., Song, H.K., Earley, C.J.·2001·Neurology

Abstract

Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2'), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2' was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.

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Crossref · 10.1212/wnl.56.2.263

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9 of 9 references verified0 citation errors · 0 not checkable

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  • Autopsy and MRI investigations show decreased iron concentrations in the substantia nigra of patients with restless leg syndrome that are associated with disease severity.

    “Autopsy and MRI investigations show decreased iron concentrations in the substantia nigra of patients with restless leg syndrome that are associated with disease severity.197,198”

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Research works printed but not linked: 1

  1. Earley CJ, Connors JR, Allen RP. RLS patients have abnormally reduced CSF ferritin compared to normal controls. Neurology . 1999; 52 (suppl 2): A111-A112.

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Authors
Allen, R. P., Barker, P. B., Wehrl, F., Song, H. K., & Earley, C. J.
Affiliations
Johns Hopkins University (US)
Venue
Neurology
Published
2001-01-23
Volume
56
Issue
2
Pages
263-265
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W2057995083
Cited by
570
References
9
Citations by year
2026: 4 · 2025: 13 · 2024: 18 · 2023: 13 · 2022: 17 · 2021: 11 · 2020: 23 · 2019: 23 · 2018: 11 · 2017: 20 · 2016: 16 · 2015: 26 · 2014: 29 · 2013: 25 · 2012: 23
FWCI
16.07
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Restless Legs Syndrome Research
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
restless legs syndrome, brain iron, iron deficiency, R2* MRI, substantia nigra, putamen, RLS severity
MeSH terms
Aged, Brain, Humans, Iron, Middle Aged, Restless Legs Syndrome

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