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Cited by 84Obstructive Sleep Apnea ResearchPregnancy and preeclampsia studiesNeuroscience of respiration and sleep

Severity of Sleep-Disordered Breathing Improves Following Parturition

Edwards, Natalie, Blyton, Diane M., Hennessy, Annemarie, Sullivan, Colin E.·2005·Sleep
DOI 10.1093/sleep/28.6.737
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Abstract

STUDY OBJECTIVE: Changes in sleep-disordered breathing associated with late pregnancy have not previously been systematically investigated; however, a number of case reports indicate exacerbation of obstructive sleep apnea in late pregnancy, often in association with maternal hypertension. We aimed to compare the severity of sleep-disordered breathing and associated maternal blood-pressure responses in late pregnancy with the nonpregnant state. DESIGN: Case-controlled, longitudinal study of sleep-disordered breathing during late pregnancy and postpartum. STUDY PATIENTS: Ten women referred for suspected sleep-disordered breathing during the third trimester of pregnancy. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: Full overnight polysomnography and continuous systemic blood pressure were measured during the third trimester of pregnancy and 3 months following delivery. Parameters of sleep-disordered breathing, including apnea hypopnea index and minimum overnight arterial oxyhemoglobin saturation, were compared between antenatal and postnatal studies. An improvement in both apnea-hypopnea index and minimum arterial oxyhemoglobin saturation occurred consistently in all subjects postnatally. In non-rapid eye movement sleep, mean apnea-hypopnea index was reduced from 63 +/- 15 per hour antenatally to 18 +/- 4 per hour postnatally (P = .03), and in rapid eye movement sleep, from 64 +/- 11 per hour to 22 +/- 4 per hour (P = .002). Minimum arterial oxyhemoglobin saturation was increased from 86% +/- 2% antenatally to 91% +/- 1% postnatally (P = .01). Arterial blood-pressure responses to apnea peaked at 170 to 180 mm Hg antenatally, while they only peaked at 130 to 140 mm Hg postnatally. CONCLUSION: This study indicates that late pregnancy may be associated with increased severity of sleep-disordered breathing and associated blood-pressure responses.

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  1. [2]2. Brownell LG, West P Kryger MH. Breathing during sleep in nomal pregnant women. Am J Respir Crit Care Med 1986;133:38-41.

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Authors
Edwards, N., Blyton, D. M., Hennessy, A., & Sullivan, C. E.
Affiliations
  • The University of Sydney (AU)
  • Royal Prince Alfred Hospital (AU)
Corresponding author
Edwards, Natalie
ORCID
Venue
Sleep
Publisher
Oxford University Press (OUP)
Published
2005-06
Volume
28
Issue
6
Pages
737-741
ISSN
  • 0161-8105 (ISSN-L)
  • 1550-9109
DOI
10.1093/sleep/28.6.737
OpenAlex
W1556479815
Semantic Scholar
bb683e927f1e289c11334f7190c6d4ce844e4d19
Cited by
84
References
29
Citations by year
2026: 1 · 2025: 4 · 2023: 3 · 2022: 7 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 2
FWCI
2.21
Type
journal article
Language
en
Open access
closed
Locations
  • SLEEP (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
sleep-disordered breathing, obstructive sleep apnea, pregnancy, postpartum period, apnea-hypopnea index, arterial oxygen saturation, maternal hypertension, third trimester
MeSH terms
Adult, Arousal, Blood Pressure, Female, Follow-Up Studies, Humans, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, Third, Severity of Illness Index, Sleep Apnea Syndromes, Sleep Stages, Case-Control Studies, Polysomnography, Continuous Positive Airway Pressure, Postpartum Period

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