Cited by 183Traumatic Brain Injury ResearchSleep and related disordersTraumatic Brain Injury and Neurovascular Disturbances

The DOI matches its Crossref record; 244 of the 245 references it cites were found in a registry or an index.

Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies

Open access

Sandsmark, Danielle K., Elliott, Jonathan E., Lim, Miranda M.·2017·Sleep

DOI 10.1093/sleep/zsx044PMC PMC6251652

Open this paper in CoChat — free account

Abstract

Sleep-wake disturbances following traumatic brain injury (TBI) are increasingly recognized as a serious consequence following injury and as a barrier to recovery. Injury-induced sleep-wake disturbances can persist for years, often impairing quality of life. Recently, there has been a nearly exponential increase in the number of primary research articles published on the pathophysiology and mechanisms underlying sleep-wake disturbances after TBI, both in animal models and in humans, including in the pediatric population. In this review, we summarize over 200 articles on the topic, most of which were identified objectively using reproducible online search terms in PubMed. Although these studies differ in terms of methodology and detailed outcomes; overall, recent research describes a common phenotype of excessive daytime sleepiness, nighttime sleep fragmentation, insomnia, and electroencephalography spectral changes after TBI. Given the heterogeneity of the human disease phenotype, rigorous translation of animal models to the human condition is critical to our understanding of the mechanisms and of the temporal course of sleep-wake disturbances after injury. Arguably, this is most effectively accomplished when animal and human studies are performed by the same or collaborating research programs. Given the number of symptoms associated with TBI that are intimately related to, or directly stem from sleep dysfunction, sleep-wake disorders represent an important area in which mechanistic-based therapies may substantially impact recovery after TBI.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/sleep/zsx044

Cites

244 of 244 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

ASSESSMENT OF COMA AND IMPAIRED CONSCIOUSNESS
Teasdale, G., & Jennett, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91639-0 · Cited by 13,215
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Family history of subarachnoid haemorrhage: supplemental value of scrutinizing all relatives.
Greebe, P., Bromberg, J. E. C., Rinkel, G. J. E., Algra, A., & van Gijn, J. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.3.273 · Cited by 4,137
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
International Classification of Sleep Disorders
Thorpy, M. (2017) · Sleep Disorders Medicine · doi:10.1007/978-1-4939-6578-6_27 · Cited by 2,505
Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration
Tononi, G., & Cirelli, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.025 · Cited by 2,356
Neurocognitive consequences of sleep deprivation
Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., et al. (2000) · Nature Medicine · doi:10.1038/79690 · Cited by 2,118

Show all 245 references

Research works printed but not linked: 3

2016, Sleep Disorders Associated With Traumatic Brain Injury, Pediatr Neurol, 60, 1
2015, Glutamatergic input to orexin neurons is decreased after mild traumatic brain injury and restored by dietary therapy, SLEEP (abstact), 55
1995, [EEG changes during sedation with gamma-hydroxybutyric acid], Anaesthesist, 44, 345

Sorted by citations

Understanding and approaching excessive daytime sleepiness
Pérez‐Carbonell, L., Mignot, E. J.-M., Leschziner, G. D., & Dauvilliers, Y. A. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01018-2 · Cited by 246
Sleep in the United States Military
Good, C. H., Brager, A. J., Capaldi, V. F., & Mysliwiec, V. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0431-7 · Cited by 204
Concussion Guidelines Step 2: Evidence for Subtype Classification
Lumba‐Brown, A., Teramoto, M., Bloom, O. J., Brody, D. L., Chesnutt, J. C., Clugston, J. R., Collins, M. W., Gioia, G. A., Kontos, A. P., Lal, A., et al. (2019) · Neurosurgery · doi:10.1093/neuros/nyz332 · Cited by 166
Concussion As a Multi-Scale Complex System: An Interdisciplinary Synthesis of Current Knowledge
Kenzie, E. S., Parks, E. L., Bigler, E. D., Lim, M. M., Chesnutt, J. C., & Wakeland, W. W. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00513 · Cited by 164
Self-citation
Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury
Holden, S. S., Grandi, F. C., Aboubakr, O., Higashikubo, B., Cho, F. S., Chang, A. H., Forero, A. O., Morningstar, A. R., Mathur, V., Kuhn, L. J., et al. (2021) · Science · doi:10.1126/science.abj2685 · Cited by 133
Metabolomics in Sleep, Insomnia and Sleep Apnea
Humer, E. C., Pieh, C., & Brandmayr, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197244 · Cited by 133
Moderate and Severe Traumatic Brain Injury
Robinson, C. P. (2021) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001036 · Cited by 120
Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction
Piantino, J. A., Lim, M. M., Newgard, C. D., & Iliff, J. J. (2019) · Current Pain and Headache Reports · doi:10.1007/s11916-019-0799-4 · Cited by 98
Self-citation
Increased Sleep Disturbances and Pain in Veterans With Comorbid Traumatic Brain Injury and Posttraumatic Stress Disorder
Balba, N. M., Elliott, J. E., Weymann, K. B., Opel, R. A., Duke, J. W., Oken, B., Morasco, B. J., Heinricher, M. M., & Lim, M. M. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7482 · Cited by 75
Self-citation
Effects of traumatic brain injury on sleep and enlarged perivascular spaces
Opel, R. A., Christy, A. L., Boespflug, E. L., Weymann, K. B., Case, B. M., Pollock, J. M., Silbert, L. C., & Lim, M. M. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18791632 · Cited by 67
Self-citation
Traumatic Brain Injury and Incidence Risk of Sleep Disorders in Nearly 200,000 US Veterans
Leng, Y., Byers, A. L., Barnes, D. E., Peltz, C. B., Li, Y., & Yaffe, K. S. (2021) · Neurology · doi:10.1212/wnl.0000000000011656 · Cited by 65
The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer’s Disease
Green, T. R. F., Ortiz, J. B., Wonnacott, S., Williams, R. J., & Rowe, R. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00894 · Cited by 68
Poor sleep is linked to impeded recovery from traumatic brain injury
Kalmbach, D. A., Conroy, D. A., Falk, H. J., Rao, V., Roy, D., Peters, M. E., Meter, T. E. V., & Korley, F. K. (2018) · SLEEP · doi:10.1093/sleep/zsy147 · Cited by 67
Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma neurofilament light, a biomarker of injury severity
Butler, T., Zhou, L., Özşahin, İ., Wang, X. H., Garetti, J., Zetterberg, H., Blennow, K., Jamison, K. W., de Leon, M. J., Li, Y., et al. (2023) · Brain Communications · doi:10.1093/braincomms/fcad134 · Cited by 61
The glymphatic system’s role in traumatic brain injury-related neurodegeneration
Peters, M. E., & Lyketsos, C. G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02070-7 · Cited by 57
A systematic review and meta-analysis of sleep architecture and chronic traumatic brain injury
Mantua, J., Grillakis, A. A., Mahfouz, S. H., Taylor, M. R., Brager, A. J., Yarnell, A. M., Balkin, T. J., Capaldi, V. F., & Simonelli, G. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.01.004 · Cited by 60
Post-Intensive-Care Syndrome for the Pediatric Neurologist
Hartman, M. E., Williams, C. N., Hall, T. A., Bosworth, C. C., & Piantino, J. A. (2020) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2020.02.003 · Cited by 54
Dietary therapy restores glutamatergic input to orexin/hypocretin neurons after traumatic brain injury in mice
Elliott, J. E., De Luche, S. E., Churchill, M. J., Moore, C., Cohen, A. S., Meshul, C. K., & Lim, M. M. (2018) · Sleep · doi:10.1093/sleep/zsx212 · Cited by 63
Self-citation
Roadmap for Advancing Pre-Clinical Science in Traumatic Brain Injury
Smith, D. H., Kochanek, P. M., Rosi, S., Meyer, R., Ferland‐Beckham, C., Prager, E. M., Ahlers, S. T., & Crawford, F. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2021.0094 · Cited by 46
Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila
van Alphen, B., Stewart, S., Iwanaszko, M., Xu, F., Li, K., Rozenfeld, S., Ramakrishnan, A., Itoh, T. Q., Sisobhan, S., Qin, Z., et al. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001456 · Cited by 54
Acute peripheral inflammation and post‐traumatic sleep differ between sexes after experimental diffuse brain injury
Saber, M., Giordano, K. R., Hur, Y., Ortiz, J. B., Morrison, H., Godbout, J. P., Murphy, S. M., Lifshitz, J., & Rowe, R. K. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14611 · Cited by 46
Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice
Roberson, S. W., Patel, M. B., Dąbrowski, W., Ely, E. W., Pakulski, C., & Kotfis, K. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210119153839 · Cited by 50
A comprehensive evaluation of insomnia, obstructive sleep apnea and comorbid insomnia and obstructive sleep apnea in US military personnel
Mysliwiec, V., Brock, M. S., Pruiksma, K. E., Straud, C. L., Taylor, D. J., Hansen, S. L., Foster, S. N., Mithani, S., Zwetzig, S. E., Gerwell, K. M., et al. (2022) · SLEEP · doi:10.1093/sleep/zsac203 · Cited by 48
Insomnia in neurological diseases
Mayer, G., Happe, S., Evers, S., Hermann, W., Jansen, S., Kallweit, U., Muntean, M., Pöhlau, D., Riemann, D. W., Saletu, M., et al. (2021) · Neurological Research and Practice · doi:10.1186/s42466-021-00106-3 · Cited by 50
The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review
Babiloni, A. H., Baril, A., Charlebois‐Plante, C., Jodoin, M., Sanchez, E., Baets, L. D., Arbour, C., Lavigne, G. J., Gosselin, N., & Beaumont, L. D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051793 · Cited by 47
Sleep therapeutics and neuropsychiatric illness
Krystal, A. D. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0474-9 · Cited by 44
Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study
Campos-Pires, R., Onggradito, H., Ujvári, E., Karimi, S., Valeo, F., Aldhoun, J. A., Edge, C. J., Franks, N. P., & Dickinson, R. (2020) · Critical Care · doi:10.1186/s13054-020-03373-9 · Cited by 42
Sleep disturbance and recovery during rehabilitation after traumatic brain injury: a systematic review
Lowe, A., Neligan, A., & Greenwood, R. (2019) · Disability and Rehabilitation · doi:10.1080/09638288.2018.1516819 · Cited by 40
Sleep Disturbances in Traumatic Brain Injury: Associations With Sensory Sensitivity
Elliott, J. E., Opel, R. A., Weymann, K. B., Chau, A. Q., Papesh, M. A., Callahan, M. L., Storzbach, D. M., & Lim, M. M. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7220 · Cited by 43
Self-citation
A Systematic Review of Sleep-Wake Disturbances in Childhood Traumatic Brain Injury: Relationship with Fatigue, Depression, and Quality of Life
Botchway-Commey, E. N., Godfrey, C., Anderson, V. A., & Catroppa, C. (2018) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000446 · Cited by 42
Toward development of clinically translatable diagnostic and prognostic metrics of traumatic brain injury using animal models: A review and a look forward
Hajiaghamemar, M., Seidi, M., Oeur, A., & Margulies, S. S. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.04.019 · Cited by 37
The impact of exercise, sleep, and diet on neurocognitive recovery from mild traumatic brain injury in older adults: A narrative review
Markovic, S. J., Fitzgerald, M., Peiffer, J. J., Scott, B. R., Rainey‐Smith, S. R., Sohrabi, H. R., & Brown, B. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101322 · Cited by 37
Hypocretin Mediates Sleep and Wake Disturbances in a Mouse Model of Traumatic Brain Injury
Thomasy, H. E., & Opp, M. R. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.5810 · Cited by 35
Lipoxins in the Nervous System: Brighter Prospects for Neuroprotection
Zhang, J., Li, Z., Fan, M., & Jin, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.781889 · Cited by 35
Sleep‐wake characteristics in a mouse model of severe traumatic brain injury: Relation to posttraumatic epilepsy
Konduru, S. S., Wallace, E. P., Pfammatter, J. A., Rodrigues, P. V., Jones, M. V., & Maganti, R. K. (2021) · Epilepsia Open · doi:10.1002/epi4.12462 · Cited by 33
Concussion history influences sleep disturbances, symptoms, and quality of life in collegiate student-athletes
Blake, A. L., McVicar, C. L., Retino, M., Hall, E. E., & Ketcham, C. J. (2018) · Sleep Health · doi:10.1016/j.sleh.2018.10.011 · Cited by 35
Cognitive Dysfunction After Analgesia and Sedation: Out of the Operating Room and Into the Pediatric Intensive Care Unit
Turner, A. D., Sullivan, T. M., Drury, K., Hall, T. A., Williams, C. N., Guilliams, K. P., Murphy, S. A., & O'Meara, A. M. I. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.713668 · Cited by 35
Sleep deficiency as a driver of cellular stress and damage in neurological disorders
Coulson, R. L., Mourrain, P., & Wang, G. X. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101616 · Cited by 33
Sleep Quality and Emotion Regulation Interact to Predict Anxiety in Veterans with PTSD
Mantua, J., Helms, S. M., Weymann, K. B., Capaldi, V. F., & Lim, M. M. (2018) · Behavioural Neurology · doi:10.1155/2018/7940832 · Cited by 31
Self-citation
Sleep assessment in a randomized trial of hyperbaric oxygen in U.S. service members with post concussive mild traumatic brain injury compared to normal controls
Walker, J. M., Mulatya, C. M., Hebert, D., Wilson, S. H., Lindblad, A. S., & Weaver, L. K. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.06.006 · Cited by 30
Update on Insomnia after Mild Traumatic Brain Injury
Zhou, Y., & Greenwald, B. D. (2018) · Brain Sciences · doi:10.3390/brainsci8120223 · Cited by 31
Default mode network anatomy and function is linked to pediatric concussion recovery
Iyer, K. K., Zalesky, A., Barlow, K. M., & Cocchi, L. (2019) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.50951 · Cited by 31
Optimized Sleep After Brain Injury (OSABI): A Pilot Study of a Sleep Hygiene Intervention for Individuals With Moderate to Severe Traumatic Brain Injury
Makley, M. J., Gerber, D., Newman, J. K., Philippus, A. H., Monden, K. R., Biggs, J., Spier, E., Tarwater, P. M., & Weintraub, A. H. (2019) · Neurorehabilitation and neural repair · doi:10.1177/1545968319895478 · Cited by 31
Investigation of Machine Learning Approaches for Traumatic Brain Injury Classification via EEG Assessment in Mice
Vishwanath, M., Jafarlou, S., Shin, I., Lim, M., Dutt, N., Rahmani, A.-M., & Cao, H. (2020) · Italian National Conference on Sensors · doi:10.3390/s20072027 · Cited by 30
Self-citation
Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery
Luther, M. N., Cordts, K. M. P., & Williams, C. N. (2020) · SLEEP · doi:10.1093/sleep/zsaa083 · Cited by 31
The Prevalence and Stability of Sleep-Wake Disturbance and Fatigue throughout the First Year after Mild Traumatic Brain Injury
Saksvik, S. B., Karaliute, M., Kallestad, H., Follestad, T., Asarnow, R. F., Vik, A., Haberg, A. K., Skandsen, T., & Olsen, A. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6898 · Cited by 30
Sleep deprivation and NLRP3 inflammasome: Is there a causal relationship?
Amini, M., Yousefi, Z., Ghafori, S. S., & Hassanzadeh, G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1018628 · Cited by 33
Sleep-Wake Disturbances After Acquired Brain Injury in Children Surviving Critical Care
Williams, C. N., Hartman, M. E., McEvoy, C. T., Hall, T. A., Lim, M. M., Shea, S. A., Luther, M. N., Guilliams, K. P., Guerriero, R. M., Bosworth, C. C., et al. (2019) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2019.08.010 · Cited by 28
Self-citation
Clinical correlates of insomnia in patients with persistent post-traumatic headache compared with migraine
Kim, S. K., Chong, C. D., Dumkrieger, G. M., Ross, K., Berisha, V., & Schwedt, T. J. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01103-8 · Cited by 30
A Raspberry Pi-Based Traumatic Brain Injury Detection System for Single-Channel Electroencephalogram
Dhillon, N. S., Sutandi, A., Vishwanath, M., Lim, M. M., Cao, H., & Si, D. (2021) · Sensors · doi:10.3390/s21082779 · Cited by 28
Self-citation
Effects of RF‐EMF on the Human Resting‐State EEG—the Inconsistencies in the Consistency. Part 1: Non‐Exposure‐Related Limitations of Comparability Between Studies
Danker‐Hopfe, H., Eggert, T., Dorn, H., & Sauter, C. (2019) · Bioelectromagnetics · doi:10.1002/bem.22194 · Cited by 28
The role of sleep deficiency in the trajectory of postconcussive symptoms in adolescents
Tham, S. W., Aaron, R. V., & Palermo, T. M. (2019) · Brain Injury · doi:10.1080/02699052.2019.1643921 · Cited by 29
The relationship between depressive symptoms, somatic complaints, and concussion history with poor sleep in collegiate athletes
Duffield, T. C., Lim, M. M., Novak, M. A., Lin, A. L., Luther, M. N., Williams, C. N., & Piantino, J. A. (2020) · Sleep Health · doi:10.1016/j.sleh.2020.06.009 · Cited by 32
Self-citation
Secondary thalamic neuroinflammation after focal cortical stroke and traumatic injury mirrors corticothalamic functional connectivity
Necula, D., Cho, F. S., He, A., & Paz, J. T. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25259 · Cited by 27
Concurrent Mild Traumatic Brain Injury and Posttraumatic Stress Disorder Is Associated With Elevated Tau Concentrations in Peripheral Blood Plasma
Pattinson, C. L., Gill, J., Lippa, S. M., Brickell, T. A., French, L. M., & Lange, R. T. (2019) · Journal of Traumatic Stress · doi:10.1002/jts.22418 · Cited by 26
Bypassing TBI: Metabolic Surgery and the Link between Obesity and Traumatic Brain Injury—a Review
McGlennon, T. W., Buchwald, J. N., Pories, W. J., Yu, F., Roberts, A. J., Ahnfeldt, E. P., Menon, R., & Buchwald, H. (2020) · Obesity Surgery · doi:10.1007/s11695-020-05065-3 · Cited by 25
Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets
Padmakumar, S., Kulkarni, P., Ferris, C. F., Bleier, B. S., & Amiji, M. M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112812 · Cited by 27
Postintensive Care Syndrome in Pediatric Critical Care Survivors: Therapeutic Options to Improve Outcomes After Acquired Brain Injury
Williams, C. N., Hartman, M. E., Guilliams, K. P., Guerriero, R. M., Piantino, J. A., Bosworth, C. C., Leonard, S. S., Bradbury, K. R., Wagner, A., & Hall, T. A. (2019) · Current Treatment Options in Neurology · doi:10.1007/s11940-019-0586-x · Cited by 25
Sleep disturbances following traumatic brain injury are associated with poor neurobehavioral outcomes in US military service members and veterans
Pattinson, C. L., Brickell, T. A., Bailie, J. M., Hungerford, L. D., Lippa, S. M., French, L. M., & Lange, R. T. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9454 · Cited by 24
Sleep outcomes in pediatric mild traumatic brain injury: a systematic review and meta-analysis of prevalence and contributing factors
Djukic, S., Phillips, N. L., & Lah, S. S. (2022) · Brain Injury · doi:10.1080/02699052.2022.2140198 · Cited by 25
The Effect of Traumatic Brain Injury on Sleep Architecture and Circadian Rhythms in Mice—A Comparison of High-Frequency Head Impact and Controlled Cortical Injury
Korthas, H. T., Main, B. S., Harvey, A. C., Buenaventura, R. G., Wicker, E., Forcelli, P. A., & Burns, M. P. (2022) · Biology · doi:10.3390/biology11071031 · Cited by 23
Experimental diffuse brain injury and a model of Alzheimer's disease exhibit disease‐specific changes in sleep and incongruous peripheral inflammation
Saber, M., Murphy, S. M., Cho, Y., Lifshitz, J., & Rowe, R. K. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24771 · Cited by 21
Dietary supplementation with branched chain amino acids to improve sleep in veterans with traumatic brain injury: a randomized double-blind placebo-controlled pilot and feasibility trial
Elliott, J. E., Keil, A. T., Mithani, S., Gill, J. M., O’Neil, M. E., Cohen, A. S., & Lim, M. M. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.854874 · Cited by 22
Self-citation
Many faces of sleep regulation: beyond the time of day and prior wake time
Duhart, J. M., Inami, S., & Koh, K. (2021) · FEBS Journal · doi:10.1111/febs.16320 · Cited by 22
Evaluation of the correlation between sleep quality and work engagement among nurses in Shanghai during the post‐epidemic era
Zhuang, H., Ma, L., Liu, Q., Wei‐ying, Z., Yu, H., & Wei, Z. (2023) · Nursing Open · doi:10.1002/nop2.1735 · Cited by 22
Sleep disturbance after pediatric traumatic brain injury: critical knowledge gaps remain for the critically injured
Williams, C. N., Lim, M. M., & Shea, S. A. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s174608 · Cited by 22
Self-citation
Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice
Zhou, X., Oishi, Y., Chérasse, Y., Korkutata, M., Fujii, S., Lee, C.-Y., & Lazarus, M. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.01.020 · Cited by 21
Clinical utility of PTSD, resilience, sleep, and blast as risk factors to predict poor neurobehavioral functioning following traumatic brain injury: A longitudinal study in U.S. military service members
Lange, R. T., French, L. M., Bailie, J. M., Merritt, V. C., Pattinson, C. L., Hungerford, L. D., Lippa, S. M., & Brickell, T. A. (2022) · Quality of Life Research · doi:10.1007/s11136-022-03092-4 · Cited by 23
Immune-endocrine interactions in the pathophysiology of sleep-wake disturbances following traumatic brain injury: A narrative review
Rowe, R. K., & Griesbach, G. S. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.04.017 · Cited by 21
Obstructive sleep apnea among survivors of combat-related traumatic injury: a retrospective cohort study
Haynes, Z. A., Stewart, I. J., Poltavskiy, E. A., Holley, A. B., Janak, J. C., Howard, J. T., Watrous, J. R., Walker, L. E., Wickwire, E. M., Werner, J. K., et al. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9530 · Cited by 18
Sleep and Executive Functioning in Pediatric Traumatic Brain Injury Survivors after Critical Care
Williams, C. N., McEvoy, C. T., Lim, M. M., Shea, S. A., Kumar, V., Nagarajan, V. D., Drury, K., Rich-Wimmer, N., & Hall, T. A. (2022) · Children · doi:10.3390/children9050748 · Cited by 18
Self-citation
Dual orexin antagonist normalized sleep homeostatic drive, enhanced GABAergic inhibition, and suppressed seizures after traumatic brain injury
Konduru, S. R., Isaacson, J. R., Lasky, D. J., Zhou, Z., Rao, R. K., Vattem, S. S., Rewey, S. J., Jones, M. V., & Maganti, R. K. (2022) · SLEEP · doi:10.1093/sleep/zsac238 · Cited by 18
Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential
Bell, A., Hewins, B., Bishop, C., Fortin, A. H., Wang, J., Creamer, J. L., Collen, J. F., & Werner, J. K. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5020016 · Cited by 19
Feasibility and preliminary efficacy for morning bright light therapy to improve sleep and plasma biomarkers in US Veterans with TBI. A prospective, open-label, single-arm trial
Elliott, J. E., McBride, A. A., Balba, N. M., Thomas, S. V., Pattinson, C. L., Morasco, B. J., Wilkerson, A. M., Gill, J., & Lim, M. M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262955 · Cited by 19
Self-citation
The immunological landscape of traumatic brain injury: insights from pathophysiology to experimental models
Abikenari, M. A., Ha, J. H., Liu, J., Ren, A. L., Cho, K. B., Lim, J., Kim, L. H., Medikonda, R. T., Choi, J. H., & Lim, M. K. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1668480 · Cited by 18
Self-citation
The Utility of Melatonin for the Treatment of Sleep Disturbance After Traumatic Brain Injury: A Scoping Review
Cassimatis, M., Browne, G. J., & Orr, R. (2022) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2022.09.018 · Cited by 17
Sleep Supports Memory and Learning: Implications for Clinical Practice in Speech-Language Pathology
Morrow, E. L., & Duff, M. C. (2020) · American Journal of Speech-Language Pathology · doi:10.1044/2019_ajslp-19-00125 · Cited by 17
Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions
Reddy, D. S., Golub, V. M., Ramakrishnan, S., Churn, S. B., Shapiro, L. A., Iannucci, J., Pitkänen, A., Galanopoulou, A. S., Maganti, R. K., & Boison, D. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100080 · Cited by 18
Traumatic brain injury and sleep disturbances in combat-exposed service members and veterans: Where to go next?
McKeon, A. B., Stocker, R., & Germain, A. (2019) · Neurorehabilitation · doi:10.3233/nre-192804 · Cited by 16
Post-concussive symptoms mediate the relationship between sleep problems and participation restrictions among veterans with mild traumatic brain injury
Kinney, A. R., Yan, X.-D., Schneider, A. L., King, S., Forster, J. E., Bahraini, N. H., & Brenner, L. A. (2022) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2022.964420 · Cited by 16
Intracerebral hemorrhage in the mouse altered sleep-wake patterns and activated microglia
Giordano, K. R., Denman, C. R., Dollish, H. K., Fernandez, F., Lifshitz, J., Akhter, M., & Rowe, R. K. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113242 · Cited by 16
Treatments for sleep disturbances in individuals with acquired brain injury: A systematic review
Pilon, L., Frankenmolen, N., & Bertens, D. (2021) · Clinical Rehabilitation · doi:10.1177/02692155211014827 · Cited by 11
The effect of phototherapy on sleep during acute rehabilitation after traumatic brain injury: a randomized controlled trial
Bell, K. R., Fogelberg, D. J., Barber, J. K., Nakase‐Richardson, R., Zumsteg, J. M., Dubiel, R., Dams-O’Connor, K., & Hoffman, J. M. (2021) · Brain Injury · doi:10.1080/02699052.2021.1871952 · Cited by 16
The growing gap: A study of sleep, encoding, and consolidation of new words in chronic traumatic brain injury
Morrow, E. L., Mayberry, L. S., & Duff, M. C. (2023) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2023.108518 · Cited by 18
Repetitive Brain Injury of Juvenile Mice Impairs Environmental Enrichment-Induced Modulation of REM Sleep in Adulthood
Borniger, J. C., Ungerleider, K., Zhang, N., Karelina, K., Magalang, U. J., & Weil, Z. M. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.064 · Cited by 15
Sleep and agitation during subacute traumatic brain injury rehabilitation: A scoping review
Poulsen, I., Langhorn, L., Egerod, I., & Aadal, L. (2020) · Australian Critical Care · doi:10.1016/j.aucc.2020.05.006 · Cited by 15
Hyperarousal symptoms and decreased right hemispheric frontolimbic white matter integrity predict poorer sleep quality in combat-exposed veterans
Bottari, S. A., Lamb, D. G., Murphy, A. J., Porges, E. C., Rieke, J. D., Harciarek, M., Datta, S., & Williamson, J. B. (2021) · Brain Injury · doi:10.1080/02699052.2021.1927186 · Cited by 17
Blast Exposure Dysregulates Nighttime Melatonin Synthesis and Signaling in the Pineal Gland: A Potential Mechanism of Blast-Induced Sleep Disruptions
Govindarajulu, M., Patel, M. Y., Wilder, D. M., Long, J. B., & Arun, P. (2022) · Brain Sciences · doi:10.3390/brainsci12101340 · Cited by 15
Traumatic Brain Injury–Induced Fear Generalization in Mice Involves Hippocampal Memory Trace Dysfunction and Is Alleviated by (R,S)-Ketamine
McGowan, J. C., Ladner, L. R., Shubeck, C., Tapia, J., LaGamma, C. T., Anqueira-González, A., DeFrancesco, A., Chen, B. K., Hunsberger, H. C., Sydnor, E., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.06.030 · Cited by 14
Microglia depletion and cognitive functions after brain injury: From trauma to galactic cosmic ray
Paladini, M. S., Feng, X., Krukowski, K., & Rosi, S. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135462 · Cited by 16
Lipoxins as Modulators of Diseases
Saqib, U., Pandey, M., Vyas, A., Patidar, P., Hajela, S., Ali, A., Tiwari, M., Sarkar, S., Yadav, N., Patel, S. S., et al. (2025) · Cells · doi:10.3390/cells14161244 · Cited by 14
Mild Traumatic Brain Injury Affects Orexin/Hypocretin Physiology Differently in Male and Female Mice
Somach, R. T., Jean, I. D., Farrugia, A. M., & Cohen, A. S. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2023.0125 · Cited by 13
Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with rapid eye movement sleep behavior disorder: a substudy of the North American Prodromal Synucleinopathy Consortium
Elliott, J. E., Ligman, B. R., Bryant‐Ekstrand, M., Keil, A. T., Powers, K., Olivo, C., Neilson, L. E., Postuma, R. B., Pelletier, A., Gagnon, J., et al. (2024) · SLEEP · doi:10.1093/sleep/zsae007 · Cited by 15
Self-citation
Sleep disturbance and cognition in people with TBI
Larson, E. B. (2018) · Neurorehabilitation · doi:10.3233/nre-182534 · Cited by 14
Perceiving traumatic brain injury from glymphatic system
Yang, Z., Li, P., & Wei, J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03126-6 · Cited by 13
Effect of Sleep-Related Symptoms on Recovery From a Sport-Related Concussion
DuPrey, K., Char, A., Loose, S. R., Suffredini, M. V., Walpole, K., & Cronholm, P. F. (2022) · Orthopaedic Journal of Sports Medicine · doi:10.1177/23259671221105256 · Cited by 12
A systematic review and meta-analysis of sleep following mild traumatic brain injury: A synthesis of the literature according to age and time-since-injury
Roberts, S., Owen, P. J., Warmington, S. A., Trevenen, J., Caeyenberghs, K., McDonald, S. J., Facer‐Childs, E. R., McKay, A., Bradshaw, E., Kara, S., et al. (2025) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2025.102072 · Cited by 12
Measurement of Sleep in Chronic Traumatic Brain Injury: Relationship Between Self-report and Actigraphy
Morrow, E. L., Mattis-Roesch, H., Walsh, K., & Duff, M. C. (2023) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000894 · Cited by 11
Investigation of Machine Learning and Deep Learning Approaches for Detection of Mild Traumatic Brain Injury from Human Sleep Electroencephalogram
Vishwanath, M., Jafarlou, S., Shin, I., Dutt, N. D., Rahmani, A. M., Jones, C. E., Lim, M. M., & Cao, H. (2021) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc46164.2021.9630423 · Cited by 11
Self-citation
Sleep disorders in traumatic brain injury
Paredes, I., Navarro-Main, B., & Lagares, A. (2020) · Neurocirugía (English Edition) · doi:10.1016/j.neucie.2020.12.001 · Cited by 15

Authors: Sandsmark, D. K., Elliott, J. E., & Lim, M. M.
Affiliations: University of Pennsylvania (US)
Oregon Health & Science University (US)
ORCID: Sandsmark, Danielle K.
Elliott, Jonathan E.
Lim, Miranda M.
Venue: Sleep
Publisher: Oxford University Press (OUP)
Published: 2017-03-17
Volume: 40
Issue: 5
ISSN: 0161-8105 (ISSN-L)
1550-9109
DOI: 10.1093/sleep/zsx044
PMC: PMC6251652
OpenAlex: W2596622414
Cited by: 183
References: 245
Citations by year: 2026: 5 · 2025: 19 · 2024: 14 · 2023: 19 · 2022: 31 · 2021: 29 · 2020: 25 · 2019: 19 · 2018: 20 · 2017: 2
FWCI: 2.39
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: public-domain
Locations: SLEEP (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, public-domain)
PubMed Central (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs (IK2 BX002712)
National Center for Complementary and Integrative Health (T32AT002688)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: traumatic brain injury, sleep-wake disturbances, excessive daytime sleepiness, sleep fragmentation, insomnia, pediatric traumatic brain injury, sleep disorders, brain injury recovery
MeSH terms: Brain Injuries, Traumatic, Animals, Disease Models, Animal, Electroencephalography, Humans, Sleep Initiation and Maintenance Disorders, Phenotype, Sleep Wake Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks