Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603

Diagnosis of multiple cancer types by shrunken centroids of gene expression

Tibshirani, R. J., Hastie, T. J., Narasimhan, B., & Chu, G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082099299 · Cited by 2,931

GenePattern 2.0

Reich, M. M., Liefeld, T., Gould, J., Lerner, J., Tamayo, P., & Mesirov, J. P. (2006) · Nature Genetics · doi:10.1038/ng0506-500 · Cited by 2,053

Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data

Dai, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni179 · Cited by 1,807

Cytochrome P450 and Chemical Toxicology

Guengerich, F. P. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700079z · Cited by 1,789

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.

Gelboin, H. V. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1107 · Cited by 1,280

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

Wilkening, S., Stahl, F., & Bader, A. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.8.1035 · Cited by 794

The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

Guillouzo, A., Corlu, A., Aninat, C., Glaise, D., Morel, F., & Guguen‐Guillouzo, C. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.12.003 · Cited by 714

Cytochrome P450-mediated metabolism of estrogens and its regulation in human

Tsuchiya, Y., Nakajima, M., & Yokoi, T. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.10.007 · Cited by 616

In vivo micronucleus screening in zebrafish by flow cytometry

Bihanic, F. L., Bucchianico, S. D., Karlsson, H. L., & Dreij, K. (2016) · Mutagenesis · doi:10.1093/mutage/gew032 · Cited by 20

Regulation of Benzo[a]pyrene-Induced Hepatic Lipid Accumulation through CYP1B1-Induced mTOR-Mediated Lipophagy

Bu, K.-B., Kim, M., Shin, M. K., Lee, S., & Sung, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021324 · Cited by 20

Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data

Doktorova, T. Y., Ellinger-Ziegelbauer, H. C., Vinken, M., Vanhaecke, T., van Delft, J. H. M., Kleinjans, J. C. S., Ahr, H.-J., & Rogiers, V. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0946-8 · Cited by 19

The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells.

Karameşe, M., Güvendi, B., Karameşe, S. A., Çınar, İ., Can, S., Erol, H. S., Aydın, H., Gelen, V., & Karakuş, E. (2016) · PubMed Central · Cited by 19

Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells

Kreuzer, K., Böhmert, L., Alhalabi, D., Buhrke, T., Lampen, A., & Braeuning, A. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111297 · Cited by 19

Differential Evolution between Monotocous and Polytocous Species

Ahn, H., Kim, K., Kim, H. J., Cho, S., & Kim, H. (2014) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2013.13696 · Cited by 18

A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma

Cabarcas‐Petroski, S., Meneses, P. I., & Schramm, L. (2020) · BMC Cancer · doi:10.1186/s12885-020-07569-8 · Cited by 18

Using Drugs as Molecular Probes: A Computational Chemical Biology Approach in Neurodegenerative Diseases

Emon, M. A., Kodamullil, A. T., Karki, R., Younesi, E., & Hofmann‐Apitius, M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160222 · Cited by 18

A dual mixture of persistent organic pollutants modifies carbohydrate metabolism in the human hepatic cell line HepaRG

Leblanc, A. F., Attignon, E. A., Distel, E., Karakitsios, S., Sarigiannis, D. A., Bortoli, S., Barouki, R., Coumoul, X., Aggerbeck, Μ., & Blanc, É. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108628 · Cited by 18

Advancing hepatotoxicity assessment: current advances and future directions

Kim, Y., Kim, Y., & Kim, Y. (2025) · Toxicological Research · doi:10.1007/s43188-025-00289-w · Cited by 22

Are In Vitro Cytotoxicity Assessments of Environmental Samples Useful for Characterizing the Risk of Exposure to Multiple Contaminants at the Workplace? A Systematic Review

Viegas, C., Pena, P., Gomes, B., Dias, M., Caetano, L. A., & Viegas, S. (2022) · Toxics · doi:10.3390/toxics10020072 · Cited by 17

Investigating the Different Mechanisms of Genotoxic and Non-Genotoxic Carcinogens by a Gene Set Analysis

Lee, W. J., Kim, S. C., Lee, S. J., Lee, J., Park, J. H., Yu, K. S., Lim, J., & Kwon, S. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086700 · Cited by 17

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Wolters, J. E. J., van Herwijnen, M. H. M., Theunissen, D. H. J., Jennen, D. G. J., den Hof, W. F. P. M. V., de Kok, T. M. C. M., Schaap, F. G., van Breda, S. G., & Kleinjans, J. C. S. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00337 · Cited by 17

Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury

Ren, Z., Chen, S., Ning, B., & Guo, L. (2018) · Methods in pharmacology and toxicology · doi:10.1007/978-1-4939-7677-5_8 · Cited by 17

Cell line-specific oxidative stress in cellular toxicity: A toxicogenomics-based comparison between liver and colon cell models

Deferme, L., Briedé, J. J., Claessen, S. M. H., Cavill, R., & Kleinjans, J. C. S. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.03.007 · Cited by 16

Soil quality in the Lomellina area using in vitro models and ecotoxicological assays

Baderna, D., Colombo, A., Romeo, M., Cambria, F., Teoldi, F., Lodi, M., Diomede, L., & Benfenati, E. (2014) · Environmental Research · doi:10.1016/j.envres.2014.05.030 · Cited by 17

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective

Herwig, R., Gmuender, H., Corvi, R., Bloch, K. M., Brandenburg, A., Castell, J. V., Ceelen, L. M., Chesné, C., Doktorova, T. Y., Jennen, D. G. J., et al. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1617-3 · Cited by 16

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Zárybnický, T., Matoušková, P., Skálová, L., & Boušová, I. (2020) · Nutrients · doi:10.3390/nu12061720 · Cited by 16

Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver

Cholico, G. N., Orlowska, K., Fling, R. R., Sink, W. J., Zacharewski, N. A., Fader, K. A., Nault, R., & Zacharewski, T. R. (2023) · Scientific Reports · doi:10.1038/s41598-023-31087-9 · Cited by 15

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Otumala, A. E., Hellen, D. J., Luna, C. A., Delgado, P., Dissanayaka, A., Ugwumadu, C., Oshinowo, O. T., Islam, M. M., Shen, L., Karpen, S. J., et al. (2023) · Lab on a Chip · doi:10.1039/d2lc00940d · Cited by 17

Time-course characterization of whole-transcriptome dynamics of HepG2/C3A spheroids and its toxicological implications

Kim, C., Zhu, Z., Barbazuk, W. B., Bacher, R. L., & Vulpe, C. D. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.10.004 · Cited by 16

Daily exposure to phthalates and alkylphenols alters miR biogenesis and expression in mice ovaries

Patiño-García, D., Cruz-Fernandes, L., Buñay, J., Orellana, R., & Moreno, R. D. (2020) · Journal of Molecular Endocrinology · doi:10.1530/jme-20-0149 · Cited by 15

Candidate Proficiency Test Chemicals to Address Industrial Chemical Applicability Domains for in vitro Human Cytochrome P450 Enzyme Induction

Jacobs, M. N., Kubíčková, B., & Boshoff, E. L. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.880818 · Cited by 17

Protective effects of an ethanol extract ofAngelica keiskeiagainst acetaminophen-induced hepatotoxicity in HepG2 and HepaRG cells

Choi, Y. H., Lee, H. S., Chung, C.-K., Kim, E. J., & Kang, I. (2017) · Nutrition Research and Practice · doi:10.4162/nrp.2017.11.2.97 · Cited by 15

Cell Culture Systems for Studying Hepatitis B and Hepatitis D Virus Infections

Lee, S.-H., Purdy, M. A., & Choi, Y. H. (2023) · Life · doi:10.3390/life13071527 · Cited by 14

Application of HepaRG cells for genotoxicity assessment: a review

Guo, X., Xu, H., & Seo, J. (2024) · Journal of Environmental Science and Health Part C · doi:10.1080/26896583.2024.2331956 · Cited by 14

New Models for the In Vitro Study of Liver Toxicity: 3D Culture Systems and the Role of Bioreactors

Mazzoleni, G., & Steimberg, N. (2012) · InTech eBooks · doi:10.5772/45606 · Cited by 14

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Disrupts Control of Cell Proliferation and Apoptosis in a Human Model of Adult Liver Progenitors

Svobodová, J., Procházková, J., Kabátková, M., Krkoška, M., Šmerdová, L., Líbalová, H., Topinka, J., Kléma, J., Kozubı́k, A., Machala, M., et al. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz202 · Cited by 14

Enhanced DNA adduct formation by benzo[a]pyrene in human liver cells lacking cytochrome P450 oxidoreductase

Reed, L., Jarvis, I. W. H., Phillips, D. H., & Arlt, V. M. (2020) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2020.503162 · Cited by 15

Meta-Analysis of Microarray Expression Studies on Metformin in Cancer Cell Lines

Schulten, H.-J., & Bakhashab, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133173 · Cited by 14

Assessment of fibrotic pathways induced by environmental chemicals using 3D-human liver microtissue model

Yan, L., Messner, C. J., Zhang, X., & Suter‐Dick, L. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110679 · Cited by 15

HepaRG cell line as an in vitro model for screening drug–drug interactions mediated by metabolic induction: Amiodarone used as a model substance

Ferreira, A., Rodrigues, M., Silvestre, S., Falcão, A. C., & Alves, G. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.08.004 · Cited by 13

Mathematical and Experimental Model of Oxygen Diffusion for HepaRG Cell Spheroids

Aleksandrova, A. V., Pulkova, N. P., Gerasimenko, T. N., Anisimov, N. U., Tonevitskaya, S. A., & Sakharov, D. A. (2016) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-016-3326-1 · Cited by 13

Fate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics

Léger, T., Balaguer, P., Hégarat, L. L., & Fessard, V. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130083 · Cited by 12

Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks

Rieswijk, L., Lizárraga, D., Brauers, K. J. J., Kleinjans, J. C. S., & van Delft, J. H. M. (2013) · Mutagenesis · doi:10.1093/mutage/get055 · Cited by 12

RNA-protein correlation of liver toxicity markers in HepaRG cells

Braeuning, A., Mentz, A., Schmidt, F. F., Albaum, S. P., Planatscher, H., Kalinowski, J., Joos, T. O., Poetz, O., & Lichtenstein, D. (2019) · EXCLI journal · doi:10.17179/excli2019-2005 · Cited by 12

A transcriptomic analysis of diploid and triploid Atlantic salmon lenses with and without cataracts

Olsvik, P. A., Finn, R. N., Remø, S. C., Fjelldal, P. G., Chauvigné, F., Glover, K. A., Hansen, T., & Waagbø, R. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108150 · Cited by 12

Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the β–oxidation-like pathway resulting in acrylyl-CoA conjugate buildup

Orlowska, K., Fling, R. R., Nault, R., Sink, W. J., Schilmiller, A. L., & Zacharewski, T. R. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102301 · Cited by 12

Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens

Deferme, L., Wolters, J. E. J., Claessen, S. M. H., Briedé, J. J., & Kleinjans, J. C. S. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00222 · Cited by 12

HepaRG Cells as a Model for Hepatotoxicity Studies

Guillouzo, A., & Guguen‐Guillouzo, C. (2018) · Wiley eBooks · doi:10.1002/9781119283249.ch12 · Cited by 14

Drug-Metabolizing Gene Expression Identity: Comparison Across Liver Tissues and Model Cell Lines

Arzumanian, V. A., Timofeeva, E. V., Kiseleva, O. I., & Poverennaya, E. V. (2025) · Biomedicines · doi:10.3390/biomedicines13112722 · Cited by 11

Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period

Savary, C. C., Jiang, X., Aubry, M., Jossé, R., Kopp‐Schneider, A., Hewitt, P. G., & Guillouzo, A. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.12.019 · Cited by 11

A Novel Multicellular Placental Barrier Model to Investigate the Effect of Maternal Aflatoxin B1 Exposure on Fetal-Side Neural Stem Cells

Zhou, Z., Luo, D., Li, M., Lao, G., Zhou, Z., Dinnyés, A., Xu, W., & Sun, Q. (2023) · Toxins · doi:10.3390/toxins15050312 · Cited by 11

Cytotoxicity of β-D-glucose/sucrose-coated silver nanoparticles depends on cell type, nanoparticles concentration and time of incubation

Vergallo, C., Panzarini, E., Carata, E., Ahmadi‐Zeidabadi, M., Mariano, S., Tenuzzo, B. A., & Dini, L. (2016) · AIP conference proceedings · doi:10.1063/1.4954495 · Cited by 11

Integration of cellular and molecular endpoints to assess the toxicity of polycyclic aromatic hydrocarbons in HepG2 cell line

Morgado, P. I., José, S., Wanke, R. D., Antunes, A. M. M., Cardoso, A. S., & Jordão, L. (2017) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3927 · Cited by 11

Identification of key genes and pathways between mild-moderate and severe asthmatics via bioinformatics analysis

Wu, X., Li, R., Xu, Q., Liu, F., Jiang, Y., Zhang, M., & Tong, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-06675-w · Cited by 10

Effects of Hypericum perforatum hydroalcoholic extract, hypericin, and hyperforin on cytotoxicity and CYP3A4 mRNA expression in hepatic cell lines: a comparative study

Martinho, A., Silva, S. M., Garcia, S. N., Moreno, I., Breitenfeld, L., Alves, G., Duarte, A. P., Domingues, F., Silvestre, S., & Gallardo, E. (2016) · Medicinal Chemistry Research · doi:10.1007/s00044-016-1702-z · Cited by 10

Microcystin-LR activates serine/threonine kinases and alters the phosphoproteome in human HepaRG cells

Ikumawoyi, V. O., Lynch, K. D., Iverson, D. T., Call, M. R., Yue, G. E., Prasad, B., & Clarke, J. (2024) · Toxicon · doi:10.1016/j.toxicon.2024.108072 · Cited by 11

Hepatotoxicity Screening on In Vitro Models and the Role of ’Omics

van Delft, J. H. M., Mathijs, K., Polman, J., Coonen, M. L. J., Szalowska, E., Verheyen, G. R., Goethem, F. V., Driessen, M., van de Ven, L., Ramaiahgari, S., et al. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397862-2.00010-3 · Cited by 9

Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals

Burman, A., García-Milian, R., & Whirledge, S. (2020) · Human Genomics · doi:10.1186/s40246-020-00269-1 · Cited by 7

Expression profile analysis of mycotoxin-related genes in cartilage with endemic osteochondropathy kashin-beck disease

Zhang, F., Guo, X., Wang, W., Wu, S., Ma, W., & Hua, Y. (2012) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-13-130 · Cited by 9

De novo LINE - 1 retrotransposition in HepG2 cells preferentially targets gene poor regions of chromosome 13

Bojang, P., Anderton, M. J., Roberts, R. A., & Ramos, K. S. (2014) · Genomics · doi:10.1016/j.ygeno.2014.07.001 · Cited by 9

Effects of pooling RNA from samples treated with different compounds for determining class specific biomarkers and processes in toxicogenomics

Pronk, T. E., van der Veen, J. W., Ezendam, J., Loveren, H. V., & Pennings, J. L. A. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.05.012 · Cited by 9

Evaluating the synergistic use of advanced liver models and AI for the prediction of drug-induced liver injury

Zhou, Y., Zhong, Y., & Lauschke, V. M. (2025) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2025.2461484 · Cited by 8

The pharmacology activities of Angelica keiskei Koidzumi and its efficacy and safety in humans

Wahyuni, I., Aulifa, D. L., Rosdianto, A. M., & Levita, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24119 · Cited by 8

Analysis of whole genomic expression profiles and screening of the key signaling pathways associated with pancreatic cancer.

He, C., Jiang, H., Geng, S., Sheng, H., Shen, X., Zhang, X., Zhu, S., Chen, X.-M., Yang, C., & Gao, H. (2012) · Europe PMC (PubMed Central) · Cited by 8

Predictive Toxicology

Carney, E. W., & Settivari, R. S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-387815-1.00033-2 · Cited by 8

Perinatal Exposure to Purity-Controlled Polychlorinated Biphenyl 52, 138, or 180 Alters Toxicogenomic Profiles in Peripheral Blood of Rats after 4 Months

Boever, P. D., Wens, B., Boix, J., Felipo, V., & Schoeters, G. E. R. (2013) · Chemical Research in Toxicology · doi:10.1021/tx300510v · Cited by 7

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Deferme, L., Wolters, J. E. J., Claessen, S. M. H., Theunissen, D. H. J., van den Beucken, T., Wagner, J. R., van Breda, S. G., Kleinjans, J. C. S., & Briedé, J. J. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00090 · Cited by 8

Application of Evolving Computational and Biological Platforms for Chemical Safety Assessment

Settivari, R. S., Rowlands, J. C., Wilson, D., Arnold, S. M., & Spencer, P. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803620-4.00032-3 · Cited by 8

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Kreuzer, K., Sprenger, H., & Braeuning, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073420 · Cited by 7

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Mittal, K., Crump, D., & Basu, N. (2019) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4555 · Cited by 7

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Kumar, R., Malik, M. Z., Thanaraj, T. A., Bagabir, S. A., Haque, S., Tambuwala, M. M., & Haider, S. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110915 · Cited by 7

Response to Pathophysiological Relevance of Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells

Summeren, A. V., Renes, J., Mariman, E. C. M., Kleinjans, J. C. S., & van Delft, J. H. M. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr055 · Cited by 7

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Panchuk, I., & Smirnikhina, S. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150375 · Cited by 5

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Kapri, A., Singh, D., & Onteru, S. K. (2024) · Mycotoxin Research · doi:10.1007/s12550-024-00563-0 · Cited by 5

Transcriptomic effect marker patterns of genotoxins – a comparative study with literature data

Kreuzer, K., Frenzel, F., Lampen, A., Braeuning, A., & Böhmert, L. (2019) · Journal of Applied Toxicology · doi:10.1002/jat.3928 · Cited by 5

Transcriptome analysis of Eisenia fetida chronically exposed to benzo(a)pyrene

Mayilswami, S., Krishnan, K., Naidu, R., & Megharaj, M. (2016) · Environmental Technology & Innovation · doi:10.1016/j.eti.2016.12.002 · Cited by 5

Transcriptome profiling of HepG2 cells exposed to the flame retardant 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide (DOPO)

Krivoshiev, B. V., Beemster, G. T. S., Sprangers, K., Cuypers, B., Laukens, K., Blust, R., & Husson, S. J. (2018) · Toxicology Research · doi:10.1039/c8tx00006a · Cited by 5

Requirements for designing organ-on-a-chip platforms to model the pathogenesis of liver disease

Ishida, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817202-5.00005-x · Cited by 5

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Niemeijer, M., Hiemstra, S. W., Wink, S., den Hollander, W., ter Braak, B., & van de Water, B. (2018) · Methods in pharmacology and toxicology · doi:10.1007/978-1-4939-7677-5_29 · Cited by 7

Investigations of the toxic effects of glycans-based silver nanoparticles on different types of human cells

Panzarini, E., Mariano, S., & Dini, L. (2017) · AIP conference proceedings · doi:10.1063/1.4997141 · Cited by 4

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Collins, J. M., & Wang, D. (2023) · Drug Metabolism and Disposition · doi:10.1124/dmd.123.001396 · Cited by 4

Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines

Wupperfeld, D., Fricker, G., Fer, B. B. D., & Popovic, B. (2024) · Pharmacological Reports · doi:10.1007/s43440-024-00595-4 · Cited by 6

Effect of cell treatment procedures on in vitro genotoxicity assessment

Recoules, C., Mirey, G., & Audebert, M. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03690-w · Cited by 4

Comparison of the impact of chlordecone and its metabolite chlordecol on genes involved in pesticide metabolism in HepG2 cell line

Baratzhanova, G., Saad, H. E. S., Fournier, A., Huguet, M., Joubert, O., Paul, A., Djansugurova, L., & Cakir‐Kiefer, C. (2025) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2025.104701 · Cited by 3

Impacts of small-molecule STAT3 inhibitor SC-43 on toxicity, global proteomics and metabolomics of HepG2 cells

Mao, T., He, P., Xu, Z., Lai, Y., Huang, J., Yu, Z., Li, P., & Gong, X. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116023 · Cited by 3

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Galanty, A., Paśko, P., Koczurkiewicz, P., Siedlarczyk, G., Pękala, E., & Podolak, I. (2025) · Toxicology · doi:10.1016/j.tox.2025.154189 · Cited by 3

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Madia, F., Phrakonkham, P., & Corvi, R. (2014) · Methods in pharmacology and toxicology · doi:10.1007/978-1-4939-0521-8_14 · Cited by 3

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