Cited by 703Mycotoxins in Agriculture and FoodCarcinogens and Genotoxicity AssessmentPlant Toxicity and Pharmacological Properties

Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology

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Kensler, T. W., Roebuck, B. D., Wogan, G. N., Groopman, J. D.·2011·Toxicological Sciences

Abstract

Since their discovery 50 years ago, the aflatoxins have become recognized as ubiquitous contaminants of the human food supply throughout the economically developing world. The adverse toxicological consequences of these compounds in populations are quite varied because of a wide range of exposures leading to acute effects, including rapid death, and chronic outcomes such as hepatocellular carcinoma. Furthermore, emerging studies describe a variety of general adverse health effects associated with aflatoxin, such as impaired growth in children. Aflatoxin exposures have also been demonstrated to multiplicatively increase the risk of liver cancer in people chronically infected with hepatitis B virus (HBV) illustrating the deleterious impact that even low toxin levels in the diet can pose for human health. The public health impact of aflatoxin exposure is pervasive. Aflatoxin biomarkers of internal and biologically effective doses have been integral to the establishment of the etiologic role of this toxin in human disease through better estimates of exposure, expanded knowledge of the mechanisms of disease pathogenesis, and as tools for implementing and evaluating preventive interventions.

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Crossref · 10.1093/toxsci/kfq283

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  • Biomarkers are useful when little or no food composition data exist, as is often the case for bioactive molecules such as glucosinolates or contaminants such as aflatoxins.

    “Biomarkers are also useful when little or no data exist on food composition, as is often the case for bioactive molecules such as glucosinolates or food contaminants such as aflatoxins (15,16).”

    From The food metabolome: a window over dietary exposure (2014) · cites this paper as [16]

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Research works printed but not linked: 1

  1. Busby, W. F. J., and Wogan, G. N. (1984). Aflatoxins. In Chemical Carcinogens (C. D. Searle, Ed.), pp. 945-1136. American Chemical Society, Washington, DC.

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Authors
Kensler, T. W., Roebuck, B. D., Wogan, G. N., & Groopman, J. D.
Affiliations
  • Johns Hopkins University (US)
  • Dartmouth College (US)
  • Massachusetts Institute of Technology (US)
Corresponding author
Kensler, T. W.
Venue
Toxicological Sciences
Published
2010-09-29
Volume
120
Issue
Supplement 1
Pages
S28-S48
ISSN
  • 1096-0929 (ISSN-L)
  • 1096-6080
OpenAlex
W2114426273
Cited by
703
References
146
Citations by year
2026: 43 · 2025: 38 · 2024: 47 · 2023: 35 · 2022: 37 · 2021: 57 · 2020: 44 · 2019: 53 · 2018: 52 · 2017: 52 · 2016: 50 · 2015: 55 · 2014: 50 · 2013: 47 · 2012: 27
FWCI
2.73
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Toxicological Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (CA 39416, R01CA039416, R01 CA39416)
  • National Institute of Environmental Health Sciences (P01ES006052)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Toxicity and Pharmacological Properties
Keywords
aflatoxins, mycotoxins, food contamination, hepatocellular carcinoma, hepatitis B virus, liver cancer risk, biomarkers of exposure, internal dosimetry, mechanistic toxicology, translational toxicology, public health impact, preventive interventions
MeSH terms
Aflatoxins, Animals, Environmental Exposure, Food Contamination, Humans, Poisons, Public Health, Toxicology, History, 20th Century, History, 21st Century, Translational Research, Biomedical

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