The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease
Open accessAbstract
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant and its potential as a serious environmental health threat is beginning to be recognized. Humans are exposed to acrolein per oral (food and water), respiratory (cigarette smoke, automobile exhaust, and biocide use) and dermal routes, in addition to endogenous generation (metabolism and lipid peroxidation). Acrolein has been suggested to play a role in several disease states including spinal cord injury, multiple sclerosis, Alzheimer's disease, cardiovascular disease, diabetes mellitus, and neuro-, hepato-, and nephro-toxicity. On the cellular level, acrolein exposure has diverse toxic effects, including DNA and protein adduction, oxidative stress, mitochondrial disruption, membrane damage, endoplasmic reticulum stress, and immune dysfunction. This review addresses our current understanding of each pathogenic mechanism of acrolein toxicity, with emphasis on the known and anticipated contribution to clinical disease, and potential therapies.
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Cites
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An updated overview of e-cigarette impact on human health
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Redox Signaling by Reactive Electrophiles and Oxidants
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Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision
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Behl, T., Kaur, D., Sehgal, A., Singh, S., Sharma, N., Zengin, G., Andronie-Cioara, F. L., Toma, M. M., Bungau, S., & Bumbu, A. G. (2021) · Molecules · doi:10.3390/molecules26123724 · Cited by 317
Metadata
- Authors
- Moghe, A., Ghare, S., Lamoreau, B., Mohammad, M., Barve, S., McClain, C., & Joshi-Barve, S.
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-01-24
- Volume
- 143
- Issue
- 2
- Pages
- 242-255
- ISSN
- 1096-0929 (ISSN-L)
- 1096-6080
- OpenAlex
- W2103329755
- Cited by
- 511
- References
- 123
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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