Cited by 189Reproductive Biology and FertilityCancer, Hypoxia, and MetabolismReproductive Physiology in Livestock

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Oxygen-Regulated Gene Expression in Bovine Blastocysts1

Harvey, A.J., Kind, K.L., Pantaleon, M., Armstrong, D.T., Thompson, J.G.·2004·Biology of Reproduction

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Abstract

Oxygen concentrations used during in vitro embryo culture can influence embryo development, cell numbers, and gene expression. Here we propose that the preimplantation bovine embryo possesses a molecular mechanism for the detection of, and response to, oxygen, mediated by a family of basic helix-loop-helix transcription factors, the hypoxia-inducible factors (HIFs). Day 5 compacting bovine embryos were cultured under different oxygen tensions (2%, 7%, 20%) and the effect on the expression of oxygen-regulated genes, development, and cell number allocation and HIFalpha protein localization were examined. Bovine in vitro-produced embryos responded to variations in oxygen concentration by altering gene expression. GLUT1 expression was higher following 2% oxygen culture compared with 7% and 20% cultured blastocysts. HIF mRNA expression (HIF1alpha, HIF2alpha) was unaltered by oxygen concentration. HIF2alpha protein was predominantly localized to the nucleus of blastocysts. In contrast, HIF1alpha protein was undetectable at any oxygen concentration or in the presence of the HIF protein stabilizer desferrioxamine (DFO), despite being detectable in cumulus cells following normal maturation conditions, acute anoxic culture, or in the presence of DFO. Oxygen concentration also significantly altered inner cell mass cell proportions at the blastocyst stage. These results suggest that oxygen can influence gene expression in the bovine embryo during postcompaction development and that these effects may be mediated by HIF2alpha.

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2003, Proceedings of the 34th annual conference of the Society for Reproductive Biology
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Authors: Harvey, A. J., Kind, K. L., Pantaleon, M., Armstrong, D. T., & Thompson, J. G.
Affiliations: Queen Elizabeth Hospital (AU)
The University of Queensland (AU)
Corresponding author: Harvey, A.J.
ORCID: Harvey, A.J.
Kind, K.L.
Pantaleon, M.
Thompson, J.G.
Venue: Biology of Reproduction
Publisher: Oxford University Press (OUP)
Published: 2004-10-01
Volume: 71
Issue: 4
Pages: 1108-1119
ISSN: 0006-3363 (ISSN-L)
1529-7268
DOI: 10.1095/biolreprod.104.028639
OpenAlex: W2154875545
Cited by: 189
References: 66
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 14 · 2021: 6 · 2020: 15 · 2019: 4 · 2018: 4 · 2017: 10 · 2016: 6 · 2015: 13 · 2014: 4 · 2013: 13 · 2012: 9
FWCI: 12.56
Type: journal article
Language: en
Open access: closed
Locations: Biology of Reproduction (publishedVersion)
PubMed (publishedVersion)
BioOne Complete (BioOne) (submittedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: Medical Research Council
National Health and Medical Research Council (157941)
Topics: Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
Keywords: oxygen regulation, bovine blastocyst, hypoxia-inducible factor, HIF-1α, HIF-2α, GLUT1, embryo culture, oxygen partial pressure, deferoxamine, inner cell mass, bHLH transcription factors, embryonic development, cumulus cells
MeSH terms: Endothelial PAS Domain-Containing Protein 1, Animals, Blastocyst, Cattle, Monosaccharide Transport Proteins, Oxygen, RNA, Messenger, Tissue Distribution, Transcription Factors, Gene Expression Regulation, Developmental, Vascular Endothelial Growth Factor A, Embryo Culture Techniques, Embryonic Development, Glucose Transporter Type 1, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit

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Oxygen-Regulated Gene Expression in Bovine Blastocysts1

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