The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
The Embryo and Its Future1
Abstract
The preimplantation mammalian embryo from different species appears sensitive to the environment in which it develops, either in vitro or in vivo, for example, in response to culture conditions or maternal diet. This sensitivity may lead to long-term alterations in the characteristics of fetal and/or postnatal growth and phenotype, which have implications for clinical health and biotechnological applications. We review the breadth of environmental influences that may affect early embryos and their responses to such conditions along epigenetic, metabolic, cellular, and physiological directions. In addition, we evaluate how embryo environmental responses may influence developmental potential and phenotype during later gestation. We conclude that a complex of different mechanisms may operate to associate early embryo environment with future health.
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Cites
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232
Parental imprinting of the mouse insulin-like growth factor II gene
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The Risk of Major Birth Defects after Intracytoplasmic Sperm Injection and in Vitro Fertilization
Hansen, M., Kurinczuk, J. J., Bower, C., & Webb, S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010035 · Cited by 1,083
Maternal epigenetics and methyl supplements affect agouti gene expression in A vy /a mice
Wolff, G. L., Kodell, R. L., Moore, S. R., & Cooney, C. A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.11.949 · Cited by 1,057
Placental-specific IGF-II is a major modulator of placental and fetal growth
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Low and Very Low Birth Weight in Infants Conceived with Use of Assisted Reproductive Technology
Schieve, L. A., Meikle, S. F., Ferre, C., Peterson, H. B., Jeng, G., & Wilcox, L. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010806 · Cited by 1,017
Fetal programming and adult health
Godfrey, K. M., & Barker, D. J. (2001) · Public Health Nutrition · doi:10.1079/phn2001145 · Cited by 995
Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection
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Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
Young, L. E., Fernandes, K., McEvoy, T. G., Butterwith, S. C., Gutierrez, C. G., Carolan, C., Broadbent, P. J., Robinson, J. J., Wilmut, I., & Sinclair, K. D. (2001) · Nature Genetics · doi:10.1038/84769 · Cited by 829
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Self-citation
Cited by
The Dutch Famine and Its Long-Term Consequences for Adult Health
Roseboom, T., de Rooij, S., & Painter, R. (2006) · Early Human Development · doi:10.1016/j.earlhumdev.2006.07.001 · Cited by 1,137
Prenatal exposure to the Dutch famine and disease in later life: An overview
Painter, R. C., Roseboom, T. J., & Bleker, O. P. (2005) · Reproductive Toxicology · doi:10.1016/j.reprotox.2005.04.005 · Cited by 784
Hungry in the womb: What are the consequences? Lessons from the Dutch famine
Roseboom, T. J., Painter, R. C., van Abeelen, A. F. M., Veenendaal, M. V. E., & de Rooij, S. R. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.06.017 · Cited by 488
Early onset of coronary artery disease after prenatal exposure to the Dutch famine
Painter, R. C., de Rooij, S. R., Bossuyt, P. M., Simmers, T. A., Osmond, C., Barker, D. J., Bleker, O. P., & Roseboom, T. J. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.322 · Cited by 392
Bromfield, J. J., Schjenken, J. E., Chin, P. Y., Care, A. S., Jasper, M. J., & Robertson, S. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305609111 · Cited by 375
Metadata
- Authors
- Fleming, T. P., Kwong, W. Y., Porter, R., Ursell, E., Fesenko, I., Wilkins, A., Miller, D. J., Watkins, A. J., & Eckert, J. J.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-10-01
- Volume
- 71
- Issue
- 4
- Pages
- 1046-1054
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2125432071
- Cited by
- 320
- References
- 117
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Embryo and Its Future1. https://app.cochat.ai/papers/10.1095/biolreprod.104.030957
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- Fleming, T. P., Kwong, W. Y., Porter, R., Ursell, E., Fesenko, I., Wilkins, A., Miller, D. J., Watkins, A. J., & Eckert, J. J. (2004). The Embryo and Its Future1. Biology of Reproduction. https://doi.org/10.1095/biolreprod.104.030957
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
