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Cited by 784Birth, Development, and HealthPrenatal Substance Exposure EffectsPregnancy and preeclampsia studies

Prenatal exposure to the Dutch famine and disease in later life: An overview

Painter, Rebecca C., Roseboom, Tessa J., Bleker, Otto P.·2005·Reproductive Toxicology
DOI 10.1016/j.reprotox.2005.04.005
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Abstract

Low birth weight is associated with cardiovascular disease in adulthood. Poor maternal nutrition during gestation contributes to low birth weight. In this paper, we review the findings from a cohort of 2414 people, aged 50 years, born as term singletons around the time of the 1944-1945 Dutch famine, of which 912 people participated in an interview and 741 subjects were also available for hospital examination. We found more coronary heart disease, raised lipids, altered clotting and more obesity after exposure to famine in early gestation compared to those not exposed to the famine. Exposure in mid gestation was associated with obstructive airways disease and microalbuminuria. We found decreased glucose tolerance in people exposed to famine in late gestation. These findings show that maternal undernutrition during gestation has important effects on health in later life, but that the timing of the nutritional insult determines which organ system is affected. Future research should shed more light upon the underlying pathophysiology of the far-reaching effects of prenatal exposure to famine.

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Crossref · 10.1016/j.reprotox.2005.04.005

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  • During the Dutch famine (1944-1945), babies exposed to maternal famine during late or mid-gestation were lighter, shorter, thinner and had a smaller head circumference than babies that had not been exposed to the famine.

    “During the Dutch famine (1944–1945), babies exposed to maternal famine during late or mid-gestation were lighter, shorter, thinner and had a smaller head circumference than babies that had not been exposed to the famine [97].”

    From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [97]

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Authors
Painter, R. C., Roseboom, T. J., & Bleker, O. P.
Affiliations
Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author
Painter, Rebecca C.
ORCID
Venue
Reproductive Toxicology
Publisher
Elsevier BV
Published
2005-09
Volume
20
Issue
3
Pages
345-352
ISSN
0890-6238 (ISSN-L)
DOI
10.1016/j.reprotox.2005.04.005
OpenAlex
W2009396016
Cited by
784
References
4
Citations by year
2026: 9 · 2025: 16 · 2024: 19 · 2023: 33 · 2022: 34 · 2021: 38 · 2020: 42 · 2019: 50 · 2018: 41 · 2017: 45 · 2016: 52 · 2015: 51 · 2014: 64 · 2013: 48 · 2012: 43
FWCI
5.12
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Reproductive Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
Diabetes Fonds
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
Dutch famine, prenatal famine exposure, maternal undernutrition, low birth weight, coronary artery disease, serum lipids, coagulation, obesity, obstructive airway disease, microalbuminuria, glucose tolerance, cardiovascular disease, adult health outcomes
MeSH terms
Adult, Cardiovascular Diseases, Female, Humans, Hyperlipidemias, Infant, Low Birth Weight, Infant, Newborn, Male, Middle Aged, Netherlands, Nutrition Disorders, Obesity, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Starvation

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