Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

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Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

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Role of oxidative stress in development of complications in diabetes

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Oxidative damage to DNA in diabetes mellitus

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Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

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Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

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Hydrogen Peroxide Alters Mitochondrial Activation and Insulin Secretion in Pancreatic Beta Cells

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Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression

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Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress

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Elevated Levels of Authentic Plasma Hydroperoxides in NIDDM

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New biomarker evidence of oxidative DNA damage in patients with non‐insulin‐dependent diabetes mellitus

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Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux

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Defective Plasma Antioxidant Defenses and Enhanced Susceptibility to Lipid Peroxidation in Uncomplicated IDDM

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Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

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Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species.

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Differences in the Expression of Heat-Shock Proteins and Antioxidant Enzymes between Human and Rodent Pancreatic Islets: Implications for the Pathogenesis of Insulin-Dependent Diabetes Mellitus

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Superoxide dismutase is a prophylactic against alloxan diabetes

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The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression

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Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.

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Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production.

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Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic beta-cells against oxidative stress

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Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.

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Antecedent Hyperglycemia, Not Hyperlipidemia, Is Associated With Increased Islet Triacylglycerol Content and Decreased Insulin Gene mRNA Level in Zucker Diabetic Fatty Rats

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Negative Association between Erythrocyte Reduced Glutathione Concentration and Diabetic Complications

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Supplementation of N‐acetylcysteine inhibits NFκB activation and protects against alloxan‐induced diabetes in CD‐1 mice

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Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus

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Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone

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Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets

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Antioxidant α‐tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes

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Overexpression of catalase provides partial protection to transgenic mouse beta cells

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Transgenic copper/zinc superoxide dismutase modulates susceptibility to type I diabetes.

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In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression.

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Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells

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Kaneto, H., & Matsuoka, T.-A. (2012)