The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
FOXP3+ Regulatory T Cells and T Helper 1, T Helper 2, and T Helper 17 Cells in Human Early Pregnancy Decidua1
Abstract
In pregnancy, the decidua is infiltrated by leukocytes promoting fetal development without causing immunological rejection. Murine regulatory T (Treg) cells are known to be important immune regulators at this site. The aim of the study was to characterize the phenotype and origin of Treg cells and determine the quantitative relationship between Treg, T-helper type 1 (T(H)1), T(H)2, and T(H)17 cells in first-trimester human decidua. Blood and decidual CD4(+) T cells from 18 healthy first-trimester pregnant women were analyzed for expression of Treg-cell markers (CD25, FOXP3, CD127, CTLA4, and human leukocyte antigen-DR [HLA-DR]), chemokine receptors (CCR4, CCR6, and CXCR3), and the proliferation antigen MKI67 by six-color flow cytometry. Treg cells were significantly enriched in decidua and displayed a more homogenous suppressive phenotype with more frequent expression of FOXP3, HLA-DR, and CTLA4 than in blood. More decidual Treg cells expressed MKI67, possibly explaining their enrichment at the fetal-maternal interface. Using chemokine receptor expression profiles of CCR4, CCR6, and CXCR3 as markers for T(H)1, T(H)2, and T(H)17 cells, we showed that T(H)17 cells were nearly absent in decidua, whereas T(H)2-cell frequencies were similar in blood and decidua. CCR6(+) T(H)1 cells, reported to secrete high levels of interferon gamma (IFNG), were fewer, whereas the moderately IFNG-secreting CCR6(-) T(H)1 cells were more frequent in decidua compared with blood. Our results point toward local expansion of Treg cells and low occurrence of T(H)17 cells. Furthermore, local, moderate T(H)1 activity seems to be a part of normal early pregnancy, consistent with a mild inflammatory environment controlled by Treg cells.
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Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
Liu, W., Putnam, A. L., Xu-yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A., Kapranov, P., Gingeras, T. R., de St. Groth, B. F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060772 · Cited by 2,606
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060468 · Cited by 1,512 · cited 3×
“CD127 has been proposed a surrogate surface marker for FOXP3 because these two proteins are inversely correlated, FOXP3 cells being CD127 [26, 27].”
BackgroundTransient expression of FOXP3 in human activated nonregulatory CD4 + T cells
Wang, J., Ioan‐Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2007) · European Journal of Immunology · doi:10.1002/eji.200636435 · Cited by 1,011
Volpe, E., Servant, N., Zollinger, R., Bogiatzi, S. I., Hupé, P., Barillot, E., & Soumelis, V. (2008) · Nature Immunology · doi:10.1038/ni.1613 · Cited by 938
Cited by
Fetomaternal immune cross-talk and its consequences for maternal and offspring's health
Arck, P. C., & Hecher, K. (2013) · Nature Medicine · doi:10.1038/nm.3160 · Cited by 600
Regulatory T cells in embryo implantation and the immune response to pregnancy
Robertson, S. A., Care, A. S., & Moldenhauer, L. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122182 · Cited by 462
Svensson, J., Jenmalm, M. C., Matussek, A., Geffers, R., Berg, G., & Ernerudh, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100130 · Cited by 373
Self-citationThe role of decidual immune cells on human pregnancy
Liu, S., Diao, L., Huang, C., Li, Y., Zeng, Y., & Kwak-Kim, J. Y. H. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.10.045 · Cited by 308
The gut microbiota and its role in the development of allergic disease: A wider perspective
West, C. E., Jenmalm, M. C., & Prescott, S. L. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12332 · Cited by 223
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Metadata
- Authors
- Mjösberg, J., Berg, G., Jenmalm, M. C., & Ernerudh, J.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-04-01
- Volume
- 82
- Issue
- 4
- Pages
- 698-705
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2137653739
- Cited by
- 280
- References
- 7
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mjösberg, J., Berg, G., Jenmalm, M. C., & Ernerudh, J. (2010). FOXP3+ Regulatory T Cells and T Helper 1, T Helper 2, and T Helper 17 Cells in Human Early Pregnancy Decidua1. Biology of Reproduction. https://doi.org/10.1095/biolreprod.109.081208
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