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Meiotic Origins of Maternal Age-Related Aneuploidy1
Open accessAbstract
Chromosome segregation errors in female meiosis lead to aneuploidy in the resulting egg and embryo, making them one of the leading genetic causes of spontaneous abortions and developmental disabilities in humans. It is known that aneuploidy of meiotic origin increases dramatically as women age, and current evidence suggests that most errors occur in meiosis I. Several hypotheses regarding the cause of maternal age-related aneuploidy have been proposed, including recombination errors in early meiosis, a defective spindle assembly checkpoint in meiosis I, and deterioration of sister chromatid cohesion with age. This review discusses findings in each area, and focuses especially on recent studies suggesting that deterioration of cohesion with increasing maternal age is a leading cause of age-related aneuploidy.
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Cited by
Variation in recombination frequency and distribution across eukaryotes: patterns and processes
Stapley, J., Feulner, P. G. D., Johnston, S. E., Santure, A. W., & Smadja, C. M. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0455 · Cited by 507
Mechanisms of oocyte aneuploidy associated with advanced maternal age
Mikwar, M., MacFarlane, A. J., & Marchetti, F. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108320 · Cited by 308
Cellular Mechanisms and Regulation of Quiescence
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Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion
Ansere, V. A., Ali-Mondal, S., Sathiaseelan, R., Garcia, D. N., Isola, J. V. V., Henseb, J. D., Saccon, T. D., Ocañas, S. R., Tooley, K. B., Stout, M. B., et al. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111425 · Cited by 101
Metadata
- Authors
- Chiang, T., Schultz, R. M., & Lampson, M. A.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-01
- Volume
- 86
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2102597135
- Cited by
- 219
- References
- 0
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chiang, T., Schultz, R. M., & Lampson, M. A. (2012). Meiotic Origins of Maternal Age-Related Aneuploidy1. Biology of Reproduction. https://doi.org/10.1095/biolreprod.111.094367
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