The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
The Role of Placental Nutrient Sensing in Maternal-Fetal Resource Allocation1
Open accessAbstract
The placenta mediates maternal-fetal exchange and has historically been regarded as a passive conduit for nutrients. However, emerging evidence suggests that the placenta actively responds to nutritional and metabolic signals from the mother and the fetus. We propose that the placenta integrates a multitude of maternal and fetal nutritional cues with information from intrinsic nutrient-sensing signaling pathways to match fetal demand with maternal supply by regulating maternal physiology, placental growth, and nutrient transport. This process, which we have called placental nutrient sensing, ensures optimal allocation of resources between the mother and the fetus to maximize the chances for propagation of parental genes without jeopardizing maternal health. We suggest that these mechanisms have evolved because of the evolutionary pressures of maternal undernutrition, which result in decreased placental growth and down-regulation of nutrient transporters, thereby limiting fetal growth to ensure maternal survival. These regulatory loops may also function in response to maternal overnutrition, leading to increased placental growth and nutrient transport in cases of maternal obesity or gestational diabetes. Thus, placental nutrient sensing modulates maternal-fetal resource allocation to increase the likelihood of reproductive success. This model implies that the placenta plays a critical role in mediating fetal programming and determining lifelong health.
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“In addition, maternal nutrition is a major determinant of placental development and alters the morphological, transport and endocrine characteristics of the placenta with consequences for the fetal nutrient supply in a wide range of species including laboratory and farm species as well as human and non-human primates (47, 144, 204, 522, 550).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [144]
In the citing paper
“The responses of the placenta to environmental cues, such as hypoxia and nutrition, indicate that there is significant interaction between maternal nutrient availability and fetal demands for these resources in determining maternal-fetal nutrient allocation at the level of the placenta (74,144).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [144]
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“This dynamic adaptation in placental phenotype optimises fetal fitness in the prevailing conditions while maintaining sufficient maternal resource for lactation and subsequent pregnancies (144, 193).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [144]
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Cites
Molecular mechanisms of mTOR-mediated translational control
Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020
Living with the Past: Evolution, Development, and Patterns of Disease
Gluckman, P. D., & Hanson, M. A. (2004) · Science · doi:10.1126/science.1095292 · Cited by 1,917
Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
Masuzaki, H., Ogawa, Y., Sagawa, N., Hosoda, K., Matsumoto, T., Mise, H., Nishimura, H., Yoshimasa, Y., Tanaka, I., Mori, T., et al. (1997) · Nature Medicine · doi:10.1038/nm0997-1029 · Cited by 1,277
Burton, G. J., Woods, A., Jauniaux, E. R. M., & Kingdom, J. C. (2009) · Placenta · doi:10.1016/j.placenta.2009.02.009 · Cited by 1,190
Onset of Maternal Arterial Blood Flow and Placental Oxidative Stress
Jauniaux, E., Watson, A. L., Hempstock, J., Bao, Y.-P., Skepper, J. N., & Burton, G. J. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64849-3 · Cited by 1,057
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
Inoki, K., Kim, J., & Guan, K. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134537 · Cited by 818
Disruption of imprinting caused by deletion of the H19 gene region in mice
Leighton, P. A., Ingram, R. S., Eggenschwiler, J. T., Efstratiadis, A., & Tilghman, S. M. (1995) · Nature · doi:10.1038/375034a0 · Cited by 756
TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy
Kirwan, J. P., Hauguel-De Mouzon, S., Lepercq, J., Challier, J.-C., Huston-Presley, L., Friedman, J. E., Kalhan, S. C., & Catalano, P. M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2207 · Cited by 738
Cited by
Sorted by citations
Catalano, P. M., & Shankar, K. (2017) · BMJ · doi:10.1136/bmj.j1 · Cited by 1,306
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
Napso, T., Yong, H. E. J., Lopez-Tello, J., & Sferruzzi-Perri, A. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01091 · Cited by 470
Placental Responses to Changes in the Maternal Environment Determine Fetal Growth
Dimasuay, K. G., Boeuf, P., Powell, T. L., & Jansson, T. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00012 · Cited by 258
Self-citationHemochorial placentation: development, function, and adaptations†
Soares, M. J., Varberg, K. M., & Iqbal, K. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy049 · Cited by 207
Metadata
- Authors
- Díaz, P., Powell, T. L., & Jansson, T.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Díaz, Paula
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-10-01
- Volume
- 91
- Issue
- 4
- Pages
- 82-82
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- PMC
- PMC4435028
- OpenAlex
- W2151264384
- Cited by
- 158
- References
- 128
- Citations by year
- 2026: 19 · 2025: 16 · 2024: 11 · 2023: 18 · 2022: 11 · 2021: 14 · 2020: 8 · 2019: 12 · 2018: 12 · 2017: 15 · 2016: 9 · 2015: 12 · 2014: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- National Institutes of Health (5r01hd068370-11, HD065007, HD068370)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089989, DK089989)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD071306, R01-HD068370, HD065007, R01HD065007, HD071306, HD 068370)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- placental development, nutrient transporters, maternal-fetal nutrient exchange, maternal undernutrition, maternal overnutrition, maternal obesity, gestational diabetes mellitus, fetal programming, evolutionary pressure, placenta
- MeSH terms
- Animals, Biological Transport, Female, Maternal-Fetal Exchange, Placenta, Pregnancy, Prenatal Nutritional Physiological Phenomena
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