Placental transport in response to altered maternal nutrition

Gaccioli, F.; Lager, S.; Powell, T. L.; Jansson, T.

doi:10.1017/s2040174412000529

Cited by 130Birth, Development, and HealthPregnancy and preeclampsia studiesGestational Diabetes Research and Management

Placental transport in response to altered maternal nutrition

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Gaccioli, F., Lager, S., Powell, T. L., Jansson, T.·2013·Journal of Developmental Origins of Health and Disease

DOI 10.1017/s2040174412000529PMC PMC4237017

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Abstract

The mechanisms linking maternal nutrition to fetal growth and programming of adult disease remain to be fully established. We review data on changes in placental transport in response to altered maternal nutrition, including compromized utero-placental blood flow. In human intrauterine growth restriction and in most animal models involving maternal undernutrition or restricted placental blood flow, the activity of placental transporters, in particular for amino acids, is decreased in late pregnancy. The effect of maternal overnutrition on placental transport remains largely unexplored. However, some, but not all, studies in women with diabetes giving birth to large babies indicate an upregulation of placental transporters for amino acids, glucose and fatty acids. These data support the concept that the placenta responds to maternal nutritional cues by altering placental function to match fetal growth to the ability of the maternal supply line to allocate resources to the fetus. On the other hand, some findings in humans and mice suggest that placental transporters are regulated in response to fetal demand signals. These observations are consistent with the idea that fetal signals regulate placental function to compensate for changes in nutrient availability. We propose that the placenta integrates maternal and fetal nutritional cues with information from intrinsic nutrient sensors. Together, these signals regulate placental growth and nutrient transport to balance fetal demand with the ability of the mother to support pregnancy. Thus, the placenta plays a critical role in modulating maternal–fetal resource allocation, thereby affecting fetal growth and the long-term health of the offspring.

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The placenta acts as an environmental sensor, integrating signals of the current availability of oxygen and nutrients, maternal stores of nutrient reserves and of the fetal nutrient demands for growth driven by the genes and actual mass of the fetus.
“Thus, the placenta acts as an environmental sensor, integrating signals of the current availability of oxygen and nutrients, maternal stores of nutrient reserves and of the fetal nutrient demands for growth driven by the genes and actual mass of the fetus (74,204).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [204]
Maternal nutrition is a major determinant of placental development and alters the morphological, transport and endocrine characteristics of the placenta with consequences for fetal nutrient supply in a wide range of species including laboratory and farm species as well as human and non-human primates.
“In addition, maternal nutrition is a major determinant of placental development and alters the morphological, transport and endocrine characteristics of the placenta with consequences for the fetal nutrient supply in a wide range of species including laboratory and farm species as well as human and non-human primates (47, 144, 204, 522, 550).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [204]

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Increased Maternal-Fetal Transport of Fat in Diabetes Assessed by Polyunsaturated Fatty Acid Content in Fetal Lipids
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Neutral Amino Acid Uptake by Microvillous and Basal Plasma Membrane Vesicles from Appropriate- and Small-for-Gestational Age Human Pregnancies
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Effects of Streptozotocin-Induced Diabetes in Pregnant Rats on Placental Transport and Tissue Uptake of α-Amino-Isobutyric Acid
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Placental transfer and uptake of 2-deoxyglucose in control and diabetic rats
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Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Placenta-on-a-chip: a novel platform to study the biology of the human placenta
Lee, J. S., Romero, R. J., Han, Y. M., Kim, H. C., Kim, C. J., Hong, J., & Huh, D. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1038518 · Cited by 272 · see citing works
Placental Responses to Changes in the Maternal Environment Determine Fetal Growth
Dimasuay, K. G., Boeuf, P., Powell, T. L., & Jansson, T. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00012 · Cited by 258 · see citing works
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Role of placental nutrient sensing in developmental programming
JANSSON, T., & POWELL, T. L. (2013) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3182993a2e · Cited by 172 · see citing works
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Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth
Aye, I. L. M. H., Rosario, F. J., Powell, T. L., & Jansson, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515484112 · Cited by 163 · see citing works
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Placental Nutrient Transport and Intrauterine Growth Restriction
Gaccioli, F., & Lager, S. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00040 · Cited by 163 · see citing works
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Management and Feeding Strategies in Early Life to Increase Piglet Performance and Welfare around Weaning: A Review
Blavi, L., Solà‐Oriol, D., Llonch, P., López-Vergé, S., Martín-Orúe, S. M., & Pérez, J. F. (2021) · Animals · doi:10.3390/ani11020302 · Cited by 157 · see citing works
The Role of Placental Nutrient Sensing in Maternal-Fetal Resource Allocation1
Díaz, P., Powell, T. L., & Jansson, T. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.121798 · Cited by 158 · see citing works
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Placental energy metabolism in health and disease—significance of development and implications for preeclampsia
Aye, I. L. M. H., Aiken, C., Jones, D. S., & Smith, G. C. S. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.11.005 · Cited by 155 · see citing works
Review: Adiponectin – The missing link between maternal adiposity, placental transport and fetal growth?
Aye, I. L. M. H., Powell, T. L., & Jansson, T. (2012) · Placenta · doi:10.1016/j.placenta.2012.11.024 · Cited by 151 · see citing works
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Placental transporter localization and expression in the Human: the importance of species, sex, and gestational age differences†
Walker, N., Filis, P., Soffientini, U., Bellingham, M., O’Shaughnessy, P. J., & Fowler, P. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox012 · Cited by 123 · see citing works
Placental Nutrient Transport in Gestational Diabetic Pregnancies
Castillo‐Castrejón, M., & Powell, T. L. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00306 · Cited by 113 · see citing works
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Fabrication of biomimetic placental barrier structures within a microfluidic device utilizing two-photon polymerization
Mandt, D., Gruber, P., Marković, M., Tromayer, M., Rothbauer, M., Kratz, S. R. A., Ali, S. F., Hoorick, J. V., Holnthoner, W., Mühleder, S., et al. (2018) · International Journal of Bioprinting · doi:10.18063/ijb.v4i2.144 · Cited by 103 · see citing works
Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism
Kramer, A. C., Jansson, T., Bale, T. L., & Powell, T. L. (2023) · Development · doi:10.1242/dev.202088 · Cited by 110 · see citing works
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Interleukin-1β inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts
Aye, I. L. M. H., Jansson, T., & Powell, T. L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.013 · Cited by 95 · see citing works
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Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth
Son, J. S., Liu, X., Tian, Q., Zhao, L., Chen, Y., Hu, Y., Chae, S. A., de Avila, J. M., Zhu, M. J., & Du, ‬. (2019) · The Journal of Physiology · doi:10.1113/jp277698 · Cited by 86 · see citing works
Expression and functional characterisation of System L amino acid transporters in the human term placenta
Gaccioli, F., Aye, I. L. M. H., Roos, S., Lager, S., Ramirez, V. I., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0054-8 · Cited by 85 · see citing works
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The effect of maternal Inflammation on foetal programming of metabolic disease
Ingvorsen, C., Brix, S., Ozanne, S. E., & Hellgren, L. (2015) · Acta Physiologica · doi:10.1111/apha.12533 · Cited by 80 · see citing works
Long-term consequences of obesity on female fertility and the health of the offspring
Chandrasekaran, S., & Neal-Perry, G. S. (2017) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000364 · Cited by 79 · see citing works
Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice
Rosario, F. J., Nathanielsz, P. W., Powell, T. L., & Jansson, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-03888-2 · Cited by 76 · see citing works
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Beneficial effects of intermittent fasting on steatosis and inflammation of the liver in mice fed a high-fat or a high-fructose diet
Marinho, T. D. S., Ornellas, F., Barbosa‐da‐Silva, S., Mandarim‐de‐Lacerda, C. A., & Águila, M. B. (2019) · Nutrition · doi:10.1016/j.nut.2019.02.020 · Cited by 78 · see citing works
Maternal Overweight Induced by a Diet with High Content of Saturated Fat Activates Placental mTOR and eIF2alpha Signaling and Increases Fetal Growth in Rats1
Gaccioli, F., White, V., Capobianco, E., Powell, T. L., Jawerbaum, A., & Jansson, T. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109702 · Cited by 76 · see citing works
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Adiponectin Inhibits Insulin Function in Primary Trophoblasts by PPARα-Mediated Ceramide Synthesis
Aye, I. L. M. H., Gao, X., Weintraub, S. T., Jansson, T., & Powell, T. L. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1401 · Cited by 75 · see citing works
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Placental metabolism: substrate requirements and the response to stress
Vaughan, O. R., & Fowden, A. (2016) · Reproduction in Domestic Animals · doi:10.1111/rda.12797 · Cited by 74 · see citing works
Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR
Chassen, S. S., & Jansson, T. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.024 · Cited by 66 · see citing works
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Placentome Nutrient Transporters and Mammalian Target of Rapamycin Signaling Proteins Are Altered by the Methionine Supply during Late Gestation in Dairy Cows and Are Associated with Newborn Birth Weight
Batistel, F., Alharthi, A. S., Wang, L., Parys, C., Pan, Y., Cardoso, F. C., & Loor, J. J. (2017) · Journal of Nutrition · doi:10.3945/jn.117.251876 · Cited by 66 · see citing works
Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates
Hillman, S. L., Finer, S., Smart, M., Mathews, C. S., Lowe, R., Rakyan, V. K., Hitman, G. A., & Williams, D. J. (2014) · Epigenetics · doi:10.4161/15592294.2014.989741 · Cited by 63 · see citing works
Symposium review: Late-gestation maternal factors affecting the health and development of dairy calves
Abuelo, Á. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-17278 · Cited by 56 · see citing works
mTOR folate sensing links folate availability to trophoblast cell function
Rosario, F. J., Powell, T. L., & Jansson, T. (2017) · The Journal of Physiology · doi:10.1113/jp272424 · Cited by 48 · see citing works
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Decreased maternal serum adiponectin and increased insulin-like growth factor-1 levels along with increased placental glucose transporter-1 expression in gestational diabetes mellitus: Possible role in fetal overgrowth
Manoharan, B., Bobby, Z., Dorairajan, G., Gladwin, V., Vinayagam, V., & Packirisamy, R. M. (2020) · Placenta · doi:10.1016/j.placenta.2020.11.008 · Cited by 50 · see citing works
Prenatal high‐fat diet alters placental morphology, nutrient transporter expression, and mtorc1 signaling in rat
Song, L., Sun, B., Boersma, G. J., Cordner, Z. A., Yan, J., Moran, T. H., & Tamashiro, K. L. (2017) · Obesity · doi:10.1002/oby.21821 · Cited by 44 · see citing works
Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction
Eaton, M., Davies, A., Devine, J., Zhao, X., Simmons, D. G., Maríusdóttir, E., Natale, D. R. C., Matyas, J. R., Bering, E. A., Workentine, M. L., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0226735 · Cited by 44 · see citing works
Maternal hypomagnesemia causes placental abnormalities and fetal and postnatal mortality
Schlegel, R., Cuffe, J. S. M., Moritz, K. M., & Paravicini, T. M. (2015) · Placenta · doi:10.1016/j.placenta.2015.03.011 · Cited by 43 · see citing works
TNF-αstimulates System A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signaling
Aye, I. L. M. H., Jansson, T., & Powell, T. L. (2015) · Physiological Reports · doi:10.14814/phy2.12594 · Cited by 44 · see citing works
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Maternal Vitamin and Mineral Supplementation and Rate of Maternal Weight Gain Affects Placental Expression of Energy Metabolism and Transport-Related Genes
Diniz, W. J. S., Reynolds, L. P., Borowicz, P. P., Ward, A. K. K., Sedivec, K. K. K., McCarthy, K. L., Kassetas, C. J. J., Baumgaertner, F., Kirsch, J. D., Dorsam, S. T., et al. (2021) · Genes · doi:10.3390/genes12030385 · Cited by 42 · see citing works
Undernutrition and malaria in pregnancy – a dangerous dyad?
Unger, H. W., Ashorn, P., Cates, J., Dewey, K. G., & Rogerson, S. J. (2016) · BMC Medicine · doi:10.1186/s12916-016-0695-2 · Cited by 43 · see citing works
Docosahexaenoic Acid Supplementation in Pregnancy Modulates Placental Cellular Signaling and Nutrient Transport Capacity in Obese Women
Lager, S., Ramirez, V. I., Acosta, O. M., Meireles, C. L., Miller, E., Gaccioli, F., Rosario, F. J., Gelfond, J. A. L., Hakala, K. W., Weintraub, S. T., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01384 · Cited by 39 · see citing works
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Antioxidants and Oxidative Stress: Focus in Obese Pregnancies
Alcalá, M., Gutiérrez-Vega, S., Castro, É., Guzmán‐Gutiérrez, E., Ramos, P., & Viana, M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01569 · Cited by 36 · see citing works
Paternal low protein diet and the supplementation of methyl-donors impact fetal growth and placental development in mice
Morgan, H. L., Aljumah, A., Rouillon, C., & Watkins, A. J. (2020) · Placenta · doi:10.1016/j.placenta.2020.10.020 · Cited by 40 · see citing works
Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with evidence for chronic hypoxia
Elias, A., Maki, Y., Matushewski, B. J., Nygard, K. L., Regnault, T. R. H., & Richardson, B. S. (2017) · Pediatric Research · doi:10.1038/pr.2017.92 · Cited by 34 · see citing works
Effects of Prenatal Nutrition and the Role of the Placenta in Health and Disease
Myatt, L., & Thornburg, K. L. R. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7614-0_2 · Cited by 36 · see citing works
Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction
Jansson, T., Castillo‐Castrejón, M., Gupta, M. B., Powell, T. L., & Rosario, F. J. (2020) · Clinical Science · doi:10.1042/cs20190794 · Cited by 30 · see citing works
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Effects of female obesity on conception, pregnancy and the health of offspring
Wei, W., Zhang, X., Zhou, B., Ge, B., Tian, J., & Chen, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.949228 · Cited by 30 · see citing works
A maternal high-fat, high-sucrose diet has sex-specific effects on fetal glucocorticoids with little consequence for offspring metabolism and voluntary locomotor activity in mice
Chin, E. H., Schmidt, K. L., Martel, K. M., Wong, C. K., Hamden, J. E., Gibson, W. T., Soma, K. K., & Christians, J. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174030 · Cited by 28 · see citing works
The Placenta’s Role in Sexually Dimorphic Fetal Growth Strategies
Christians, J. K. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00780-3 · Cited by 31 · see citing works
Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane Transporters
Karahoda, R., Zaugg, J., Fuenzalida, B., Kallol, S., Moser-Hässig, R., Štaud, F., & Albrecht, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.820286 · Cited by 28 · see citing works
Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis
Bulka, C. M., Everson, T. M., Burt, A., Marsit, C. J., Karagas, M. R., Boyle, K. E., Niemiec, S., Kechris, K. J., Davidson, E., Yang, I. V., et al. (2023) · Epigenetics · doi:10.1080/15592294.2023.2179726 · Cited by 28 · see citing works
Maternal body mass index impacts fetal-placental size at birth and umbilical cord oxygen values with implications for regulatory mechanisms
Richardson, B. S., Ruttinger, S., Brown, H. K., Regnault, T. R. H., & de Vrijer, B. (2017) · Early Human Development · doi:10.1016/j.earlhumdev.2017.06.009 · Cited by 27 · see citing works
Maternal Underweight and Obesity Are Associated with Placental Pathologies in Human Pregnancy
Scott, H., Grynspan, D., Anderson, L. N., & Connor, K. L. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00983-2 · Cited by 28 · see citing works
Fatty acids, inflammation and angiogenesis in women with gestational diabetes mellitus
Joshi, N. P., Madiwale, S. D., Sundrani, D. P., & Joshi, S. R. (2023) · Biochimie · doi:10.1016/j.biochi.2023.04.005 · Cited by 27 · see citing works
Placenta and Placental Transport Function
Sadovsky, Y., & Jansson, T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00039-9 · Cited by 24 · see citing works
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Interactions between nutrients in the maternal diet and the implications for the long-term health of the offspring
Rees, W. D. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118002537 · Cited by 24 · see citing works
Effects of Dietary L-arginine Supplementation from Conception to Post- Weaning in Piglets
Che, D., Adams, S., Zhao, B. X., Qin, G., & Jiang, H. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190125104959 · Cited by 24 · see citing works
Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat
Alkhalefah, A., Dunn, W. B., Allwood, J. W., Parry, K. L., Houghton, F. D., Ashton, N., & Glazier, J. D. (2021) · Clinical Science · doi:10.1042/cs20210137 · Cited by 23 · see citing works
Gestational diabetes mellitus: genetic factors, epigenetic alterations, and microbial composition
Lizárraga, D., Gómez‐Gil, B., García-Gasca, T., Ávalos-Soriano, A., Casarini, L., Salazar-Oroz, A., & Garcı́a-Gasca, A. (2023) · Acta Diabetologica · doi:10.1007/s00592-023-02176-y · Cited by 23 · see citing works
Ruminant Placental Adaptation in Early Maternal Undernutrition: An Overview
Toschi, P., & Baratta, M. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.755034 · Cited by 21 · see citing works
Reduction of In Vivo Placental Amino Acid Transport Precedes the Development of Intrauterine Growth Restriction in the Non-Human Primate
Rosario, F. J., Kramer, A. W., Li, C., Galan, H. L., Powell, T. L., Nathanielsz, P. W., & Jansson, T. (2021) · Nutrients · doi:10.3390/nu13082892 · Cited by 20 · see citing works
Self-citation
1,25-dihydroxy vitamin D3 stimulates System A amino acid transport in primary human trophoblast cells
Chen, Y.-Y., Powell, T., & Jansson, T. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.009 · Cited by 21 · see citing works
Self-citation
Stimulation of soluble guanylate cyclase diminishes intrauterine growth restriction in a rat model of placental ischemia
Coats, L. E., Bamrick, D. R., Ariatti, A. M., Bakrania, B. A., Rawls, A. Z., Ojeda, N. B., & Alexander, B. T. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00234.2020 · Cited by 19 · see citing works
Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep
Rosales-Nieto, C. A., Ehrhardt, R., Mantey, A., Makela, B., Byrem, & Veiga‐Lopez, A. (2020) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2020.106577 · Cited by 19 · see citing works
Fetal sex impacts birth to placental weight ratio and umbilical cord oxygen values with implications for regulatory mechanisms
Richardson, B. S., Rajagopaul, A., de Vrijer, B., Eastabrook, G., & Regnault, T. R. H. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00445-z · Cited by 18 · see citing works
Nutritional Programming of Intrauterine Development: A Concept Applicable to the Horse?
Fowden, A. L., Jellyman, J. K., Valenzuela, O. A., & Forhead, A. J. (2013) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2013.03.005 · Cited by 18 · see citing works
The impact of maternal diabetes on birth to placental weight ratio and umbilical cord oxygen values with implications for fetal-placental development
Choo, S., de Vrijer, B., Regnault, T. R. H., Brown, H. K., Stitt, L., & Richardson, B. S. (2023) · Placenta · doi:10.1016/j.placenta.2023.02.008 · Cited by 16 · see citing works
Vitamin B12 and placental expression of transcobalamin in pregnant adolescents
Layden, A. J., O'Brien, K. O., Pressman, E. K., Cooper, E., Kent, T. R., & Finkelstein, J. L. (2016) · Placenta · doi:10.1016/j.placenta.2016.06.011 · Cited by 16 · see citing works
Antenatal Vitamin D Preserves Placental Vascular and Fetal Growth in Experimental Chorioamnionitis Due to Intra-amniotic Endotoxin Exposure
Cookson, M. S., Ryan, S., Seedorf, G., Dodson, R. B., Abman, S. H., & Mandell, E. W. (2018) · American Journal of Perinatology · doi:10.1055/s-0038-1642033 · Cited by 16 · see citing works
Prenatal exercise reverses high-fat-diet-induced placental alterations and alters male fetal hypothalamus during late gestation in rats†
Song, L., Yan, J., Wang, N., Wei, X., Luo, X. M., Meng, K., & Sun, B. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz213 · Cited by 15 · see citing works
Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy
Kappen, C., Krüger, C., Jones, S., Herion, N. J., & Salbaum, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224754 · Cited by 13 · see citing works
Impact of maternal intermittent fasting during pregnancy on cardiovascular, metabolic and renal function in adult rat offspring
Alkhalefah, A., Eyre, H. J., Hussain, R., Glazier, J. D., & Ashton, N. (2022) · PLoS ONE · doi:10.1371/journal.pone.0258372 · Cited by 13 · see citing works
Maternal Dexamethasone Exposure Induces Sex-Specific Changes in Histomorphology and Redox Homeostasis of Rat Placenta
Trifunović, S. L., Šošić‐Jurjević, B., Ristić, N., Nestorović, N. M., Filipović, B. R., Stevanović, I. D., Begović-Kuprešanin, V., & Manojlović‐Stojanoski, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010540 · Cited by 13 · see citing works
Preexisting Diabetes and Pregnancy
Kitzmiller, J. L., Ferrara, A. M., Peng, T., Cissell, M. A., & Kim, C. (2018) · Europe PMC (PubMed Central) · Cited by 13 · see citing works
Effect of maternal hypoglycaemia during gestation on materno-foetal nutrient transfer and embryo-foetal development: Evidence from experimental studies focused primarily on the rat
Jensen, V. F. H., Mølck, A., Lykkesfeldt, J., & Bøgh, I. B. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.01.007 · Cited by 12 · see citing works
Influence of maternal one carbon metabolites on placental programming and long term health
Nema, J., Joshi, N. P., Sundrani, D. P., & Joshi, S. (2022) · Placenta · doi:10.1016/j.placenta.2022.02.022 · Cited by 14 · see citing works
Global population variation in placental size and structure: Evidence from Cebu, Philippines
Rutherford, J. N., deMartelly, V. A., Ragsdale, H. B., Avila, J. L., Lee, N. R., & Kuzawa, C. W. (2019) · Placenta · doi:10.1016/j.placenta.2019.08.076 · Cited by 11 · see citing works
Intake of Spineless Cladodes of Opuntia ficus-indica During Late Pregnancy Improves Progeny Performance in Underfed Sheep
Reyes, V. C., Santiago-Hernández, F., Flores, M., Vázquez-García, J. M., Morales, J. U., Ghaffari, M. H., Chay‐Canul, A. J., Meza-Herrera, C. A., Gonzalez‐Bulnes, A., Martin, G. B., et al. (2020) · Animals · doi:10.3390/ani10060995 · Cited by 11 · see citing works
Preterm Birth Associates With Increased Placental Expression of MDR Transporters Irrespective of Prepregnancy BMI
Scott, H., Martinelli, L. M., Grynspan, D., Bloise, E., & Connor, K. L. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab813 · Cited by 10 · see citing works
Maternal‐fetal outcomes of exercise applied in rats with mild hyperglycemia after embryonic implantation
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Influence of Maternal Supplementation with Vitamins, Minerals, and (or) Protein/Energy on Placental Development and Angiogenic Factors in Beef Heifers during Pregnancy
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Authors: Gaccioli, F., Lager, S., Powell, T. L., & Jansson, T.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Jansson, T.
ORCID: Gaccioli, F.
Lager, S.
Powell, T. L.
Jansson, T.
Venue: Journal of Developmental Origins of Health and Disease
Publisher: Cambridge University Press (CUP)
Published: 2012-07-31
Volume: 4
Issue: 2
Pages: 101-115
ISSN: 2040-1744 (ISSN-L)
2040-1752
DOI: 10.1017/s2040174412000529
PMC: PMC4237017
OpenAlex: W2164709834
Cited by: 129
References: 177
Citations by year: 2026: 13 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 13 · 2020: 11 · 2019: 7 · 2018: 10 · 2017: 15 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 4 · 2012: 1
FWCI: 4.49
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Journal of Developmental Origins of Health and Disease (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5r01hd068370-11)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089989)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD071306, R01-HD068370, R01HD065007)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords: placental nutrient transport, maternal nutrition, fetal growth restriction, maternal undernutrition, maternal overnutrition, placental blood flow, amino acid transporters, glucose transport, fatty acid uptake, fetal programming, fetal growth, diabetes in pregnancy, placental development

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Placental transport in response to altered maternal nutrition

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