Role of placental nutrient sensing in developmental programming
Open accessAbstract
Altered maternal nutrition and metabolism, restricted utero-placental blood flow, and other perturbations in the maternal compartment may disturb critical periods of fetal development resulting in increased susceptibility to develop disease in childhood and adult life. In response to these perturbations, changes in placental structure and function occur, which influence the supply of nutrients, oxygen, and methyl donors and alter the secretion of hormones and other signaling molecules into the fetal circulation. Thus, the placenta plays a critical role in modulating maternal-fetal resource allocation, thereby affecting fetal growth and the long-term health of the offspring.
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There are changes in these pathways in cases of fetal growth restriction caused by maternal starvation or impaired placentation where there is down-regulation of placental nutrient transport.
“There are also changes in these pathways in cases of fetal growth restriction caused by maternal starvation or impaired placentation where there is down-regulation of placental nutrient transport(225, 226).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [225]
The activation of mTOR is positively correlated with the first-trimester maternal body mass index, linking maternal over-nutrition and nutrient-sensing by the placenta.
“The activation of mTOR is positively correlated with the first-trimester maternal body mass index, linking maternal over-nutrition and nutritient-sensing by the placenta; while its expression is down-regulated when fetal growth is restricted (in both animal models and humans).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [225]
mTOR expression is down-regulated when fetal growth is restricted (in both animal models and humans).
“while its expression is down-regulated when fetal growth is restricted (in both animal models and humans).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [225]
Each of these nutrient-sensing pathways is present in the human placenta.
“Each of these nutritient-sensing pathways is present in the human placenta(225–227).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [225]
mTOR regulates two key amino-acid transport systems (A and L).
“mTOR regulates two key amino-acid transport systems (A and L).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [225]
mTOR has key properties in the placenta that include its activation by insulin, IGF-1, and leptin, and its inhibition by cortisol.
“mTOR has key properties in the placenta(225, 226) that include its activation by insulin, IGF-1, and leptin, and its inhibition by cortisol.”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [225]
Nutrient sensing occurs through several pathways, the most important of which are the AMPK pathway, GSK-3, the hexose-amino signaling pathway, the amino-acid response signal transduction pathway, and the mTORC1 pathway.
“Nutrient sensing occurs through several pathways(225), the most important of which are: the AMPK pathway, which is a global energy sensor in cells;glycogen synthase 3 (GSK-3), which acts as a glucose sensor;the hexose-amino signaling pathway, which depends on the availability of nutrients such as glucose, glutamine, and acetyl-CoA;the amino-acid response signal transduction pathway, which is activ”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [225]
mTOR is a major human nutrient-sensing receptor in the placenta.
“mTOR is a major human nutrient-sensing receptor in the placenta(225).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [225]
Disorders in nutrient-sensing pathways may lead to fetal growth disorders.
“Disorders in nutrient-sensing pathways may lead to fetal growth disorders, and studies by Professors Powell and Jansson have provided unique insights into nutrient sensing by the human placenta(225–227).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [225]
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- [8]Jansson T Powell TL IFPA 2005 Award in Placentology Lecture. Human Placental Transport in Altered Fetal Growth: Does the Placenta Function as a Nutrient Sensor? - A Review. Placenta 2006 27 SupplA S91 97 16442615
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- Authors
- JANSSON, T., & POWELL, T. L.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Clinical Obstetrics & Gynecology
- Published
- 2013-09
- Volume
- 56
- Issue
- 3
- Pages
- 591-601
- ISSN
- 0009-9201 (ISSN-L)
- PMC
- PMC3732521
- OpenAlex
- W1975164000
- Cited by
- 172
- References
- 3
- Citations by year
- 2026: 21 · 2025: 13 · 2024: 12 · 2023: 17 · 2022: 15 · 2021: 13 · 2020: 16 · 2019: 10 · 2018: 20 · 2017: 14 · 2016: 12 · 2015: 4 · 2014: 4 · 2013: 1
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Obstetrics & Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01hd068370-11)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089989, DK089989)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD071306, R01-HD068370, HD065007, R01HD065007, HD071306, HD 068370)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- placenta, nutrient sensing, developmental programming, fetal growth, maternal nutrition, uteroplacental blood flow, placental hormones, methyl donors, fetal development, offspring health
- MeSH terms
- Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Maternal-Fetal Exchange, Placenta, Placental Insufficiency, Pregnancy, Trophoblasts, Signal Transduction, Placental Circulation, Maternal Nutritional Physiological Phenomena, Prenatal Nutritional Physiological Phenomena, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Fetal Development, Fetal Nutrition Disorders
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