The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Vascular Endothelial Growth Factor Receptor Localization and Activation in Human Trophoblast and Choriocarcinoma Cells1
Abstract
Vascular endothelial growth factor (VEGF; also known as vascular permeability factor) is a secreted angiogenic growth factor. It is highly specific for endothelial cells, and its receptor, the fms-like tyrosine kinase (flt), has been localized only to endothelial cells in vivo. Here we describe the expression of mRNA encoding flt in human trophoblast as revealed by in situ hybridization. This mRNA is highly expressed in the cytotrophoblast shell and columns and also highly expressed by the extravillous trophoblast (EVT) in the maternal decidua both in the first trimester and at term. The trophoblast-like choriocarcinoma cell line BeWo also expresses this receptor and the related receptor, kinase domain-containing receptor (KDR), which is also a receptor for VEGF. Treatment of the cell line BeWo with VEGF165 stimulated 3H-thymidine incorporation and tyrosine phosphorylation of MAP (mitogen-activated protein) kinase in a time- and dose-dependent fashion. This study is the first demonstration of the presence of flt on non-endothelial cells in vivo and suggests a role for VEGF in the growth and differentiation of cytotrophoblast at implantation.
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Citations
Cites
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Cited by
Comparative Developmental Anatomy of the Murine and Human Definitive Placentae
Georgiades, P., Ferguson-Smith, A. C., & Burton, G. J. (2002) · Placenta · doi:10.1053/plac.2001.0738 · Cited by 641
Zhou, Y., McMaster, M., Woo, K., Janatpour, M., Perry, J., Karpanen, T., Alitalo, K., Damsky, C., & Fisher, S. J. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62567-9 · Cited by 640
Reynolds, L. P., & Redmer, D. A. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.4.1033 · Cited by 516
VEGF Receptor Signal Transduction
Matsumoto, T., & Claesson-Welsh, L. (2001) · Science's STKE · doi:10.1126/stke.2001.112.re21 · Cited by 502
Brown, L. F., Detmar, M., Claffey, K., Nagy, J. A., Feng, D., Dvorak, A. M., & Dvorak, H. F. (1997) · Experientia Supplementum · doi:10.1007/978-3-0348-9006-9_10 · Cited by 472
Metadata
- Authors
- Stephen Charnock-Jones, D., Sharkey, A. M., Boocock, C. A., Ahmed, A., Plevin, R., Ferrara, N., & Smith, S. K.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-09-01
- Volume
- 51
- Issue
- 3
- Pages
- 524-530
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W1967450352
- Cited by
- 243
- References
- 1
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Vascular Endothelial Growth Factor Receptor Localization and Activation in Human Trophoblast and Choriocarcinoma Cells1. https://app.cochat.ai/papers/10.1095/biolreprod51.3.524
- The paper
- Stephen Charnock-Jones, D., Sharkey, A. M., Boocock, C. A., Ahmed, A., Plevin, R., Ferrara, N., & Smith, S. K. (1994). Vascular Endothelial Growth Factor Receptor Localization and Activation in Human Trophoblast and Choriocarcinoma Cells1. Biology of Reproduction. https://doi.org/10.1095/biolreprod51.3.524
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
