Comparative Developmental Anatomy of the Murine and Human Definitive Placentae
Abstract
The placenta of eutherian mammals is a remarkable biological structure. It is composed of both zygote-derived and maternal cells, and mediates the complex interactions between the mother and the fetus that are necessary for fetal growth and survival. While the genetic basis of human placental development and function is largely unknown, its understanding is of immense clinical importance because placentopathies of unknown genetic aetiology are thought to be the cause of many types of pregnancy complications including unexplained miscarriage and intrauterine growth retardation. The mouse is the best-studied mammalian experimental genetic model system and research is not restricted by the inherent ethical and practical limitations associated with the human. As a result, knowledge about the genetic control of mouse placental development has expanded greatly in recent years. In order for this to be of benefit to medical practice, extrapolations from murine to human placentation have to be made. However, comprehensive comparisons of the placentae of these two species are rare. This review therefore compares the developmental anatomy of the placenta between humans and mice with emphasis on structures and cell types that might be analogous between the two species. This could be of particular benefit to mouse developmental geneticists who study placental development and have an interest in the possible clinical implications of their work.
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Internally, the mouse placenta has significant differences from the human, the most major being division into a labyrinth zone responsible primarily for exchange and a junctional zone serving an endocrine function.
“Internally, however, there are significant differences (210), the most major being that the placenta is divided into two morphologically and functionally distinct zones; the labyrinth zone that is responsible primarily for exchange and the junctional zone that serves an endocrine function (Figure 3C).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [210]
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Multidrug Resistance Phosphoglycoprotein (ABCB1) in the Mouse Placenta: Fetal Protection1
Kalabis, G. M., Kostaki, A., Andrews, M. H., Sophie Petropoulos, A., Gibb, W., & Matthews, S. G. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.042242 · Cited by 99 · see citing works
Poulet, F. M., Wolf, J. J., Herzyk, D. J., & DeGeorge, J. J. (2016) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.21176 · Cited by 97 · see citing works
Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome
Tunster, S. J., de Pette, M. V., & John, R. M. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.007328 · Cited by 94 · see citing works
- Authors
- Georgiades, P., Ferguson-Smith, A. C., & Burton, G. J.
- Affiliations
- University of Cambridge (GB)
- ORCID
- Burton, G.J.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 23
- Issue
- 1
- Pages
- 3-19
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W1994865551
- Cited by
- 641
- References
- 130
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 18 · 2023: 20 · 2022: 21 · 2021: 29 · 2020: 37 · 2019: 27 · 2018: 29 · 2017: 37 · 2016: 24 · 2015: 25 · 2014: 27 · 2013: 36 · 2012: 51
- FWCI
- 26.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- placental development, human-mouse comparison, placental mammals, maternal-fetal interaction, pregnancy complications, miscarriage, fetal growth restriction
- MeSH terms
- Adult, Animals, Female, Embryonic and Fetal Development, Humans, Maternal-Fetal Exchange, Placenta, Pregnancy, Species Specificity, Gene Expression Regulation, Developmental, Mice
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