The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
IL-15 Expression at Human Endometrium and Decidua
Abstract
A large number of natural killer (NK) cells appear in human uterine mucosa during the secretory phase and first trimester pregnancy. We investigated the expression of interleukin (IL)-15, a possible stimulator for these NK cells, in human endometrium and first trimester decidua. Semiquantitative reverse transcriptase-polymerase chain reaction revealed that IL-15 mRNA expression was stronger during the secretory phase and first trimester pregnancy than during the proliferative phase. Immunohistochemistry revealed that immunoreactivity for anti-IL-15 was higher during the secretory phase than it was during the proliferative phase. This was prominent in the perivascular stromal cells around invading spiral arteries during the mid- to late-secretory phase. In first trimester decidua, endothelial cells were also stained as strongly as stromal cells. A membrane-bound IL-15 molecule was detected on the surface of first trimester decidual cells by flow cytometry. Progesterone stimulated the release of soluble IL-15 in the supernatant of cultured decidual cells. These results suggest that IL-15 expression in human uterine mucosa corresponds to the fluctuation of uterine NK cells and that its production is hormonally controlled, especially by progesterone.
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Citations
Cites
Evaluation of oestrogen and progesterone receptor expression in uterine mucosal lymphocytes
King, A., Gardner, L., & Loke, Y. W. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019300 · Cited by 133
Cited by
Kao, L. C., Germeyer, A., Tulac, S., Lobo, S., Yang, J. P., Taylor, R. N., Osteen, K., Lessey, B. A., & Giudice, L. C. (2003) · Endocrinology · doi:10.1210/en.2003-0043 · Cited by 696
Global gene profiling in human endometrium during the window of implantation
Kao, L. C., Tulac, S., Lobo, S., Imani, B., Yang, J. P., Germeyer, A., Osteen, K., Taylor, R. N., Lessey, B. A., & Giudice, L. C. (2002) · Endocrinology · doi:10.1210/endo.143.6.8885 · Cited by 727
Endometrial NK Cells Are Special Immature Cells That Await Pregnancy
Manaster, I., Mizrahi, S., Goldman-Wohl, D., Sela, H. Y., Stern-Ginossar, N., Lankry, D., Gruda, R., Hurwitz, A., Bdolah, Y., Haimov-Kochman, R., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1869 · Cited by 263
Ashkar, A. A., Black, G. P., Wei, Q., He, H., Liang, L., Head, J. R., & Croy, B. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.2937 · Cited by 257
Wilkens, J., Male, V., Ghazal, P., Forster, T., Gibson, D. A., Williams, A. R. W., Brito-Mutunayagam, S. L., Craigon, M., Lourenco, P., Cameron, I. T., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300958 · Cited by 101
Metadata
- Authors
- Kitaya, K., Yasuda, J., Yagi, I., Tada, Y., Fushiki, S., & Honjo, H.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-09-01
- Volume
- 63
- Issue
- 3
- Pages
- 683-687
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2146154036
- Cited by
- 213
- References
- 1
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kitaya, K., Yasuda, J., Yagi, I., Tada, Y., Fushiki, S., & Honjo, H. (2000). IL-15 Expression at Human Endometrium and Decidua. Biology of Reproduction. https://doi.org/10.1095/biolreprod63.3.683
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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