The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Endometrial NK Cells Are Special Immature Cells That Await Pregnancy
Abstract
NK cells populate the human endometrium before pregnancy. Unlike decidual NK cells that populate the decidua during pregnancy, the NK cells present in the human endometrium, before pregnancy, have not been fully characterized. In this study, we provide a detailed analysis of the origin, phenotype, and function of endometrial NK cells (eNK). We show that eNK cells have a unique receptor repertoire. In particular, they are negative for NKp30 and chemokine receptor expression, which distinguishes them from any other NK subset described so far. We further show that eNK cells lack NK-specific functional phenotype and activity such as cytokine secretion and cytotoxicity, before IL-15 stimulation. Following such stimulation, endometrial NK cells acquire phenotype and function that are similar to those of decidual NK cells. We therefore suggest that eNK cells are inactive cells (before IL-15 activation and in relation to the known NK activity) that are present in the endometrium before conception, waiting for pregnancy.
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Cites
1 retracted
Novel APC-like properties of human NK cells directly regulate T cell activation
Hanna, J., Gonen-Gross, T., Fitchett, J., Rowe, T., Daniels, M., Arnon, T. I., Gazit, R., Joseph, A., Schjetne, K. W., Steinle, A., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22787 · Cited by 162
Self-citationRetractedDecidual NK cells regulate key developmental processes at the human fetal-maternal interface
Hanna, J., Goldman-Wohl, D., Hamani, Y., Avraham, I., Greenfield, C., Natanson-Yaron, S., Prus, D., Cohen-Daniel, L., Arnon, T. I., Manaster, I., et al. (2006) · Nature Medicine · doi:10.1038/nm1452 · Cited by 1,681
Self-citationCosman, D., Müllberg, J., Sutherland, C. L., Chin, W., Armitage, R., Fanslow, W., Kubin, M., & Chalupny, N. J. (2001) · Immunity · doi:10.1016/s1074-7613(01)00095-4 · Cited by 1,232
Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
Mandelboim, O., Lieberman, N., Lev, M., Paul, L., Arnon, T. I., Bushkin, Y., Davis, D. M., Strominger, J. L., Yewdell, J. W., & Porgador, A. (2001) · Nature · doi:10.1038/35059110 · Cited by 990
Self-citationHuman Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential
Koopman, L. A., Kopcow, H. D., Rybalov, B., Boyson, J. E., Orange, J. S., Schatz, F., Masch, R., Lockwood, C. J., Schachter, A. D., Park, P. J., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030305 · Cited by 909
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Pende, D., Parolini, S., Pessino, A., Sivori, S., Augugliaro, R., Morelli, L., Marcenaro, E., Accame, L., Malaspina, A., Biassoni, R., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.10.1505 · Cited by 798
Comparative studies of human FcRIII-positive and negative natural killer cells.
Nagler, A., Lanier, L. L., Cwirla, S., & Phillips, J. H. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.10.3183 · Cited by 696
Ferlazzo, G., Thomas, D., Lin, S.-L., Goodman, K., Morandi, B., Muller, W. A., Moretta, A., & Münz, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1455 · Cited by 589
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Cited by
The unique immunological and microbial aspects of pregnancy
Mor, G., Aldo, P., & Alvero, A. B. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.64 · Cited by 1,041
The role of sex hormones in immune protection of the female reproductive tract
Wira, C. R., Rodriguez-Garcia, M., & Patel, M. V. (2015) · Nature Reviews Immunology · doi:10.1038/nri3819 · Cited by 444
Uterine NK cells and macrophages in pregnancy
Faas, M. M., & de Vos, P. (2017) · Placenta · doi:10.1016/j.placenta.2017.03.001 · Cited by 312
Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies
Gamliel, M., Goldman-Wohl, D., Isaacson, B., Gur, C., Stein, N., Yamin, R., Berger, M., Grunewald, M., Keshet, E., Rais, Y., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.030 · Cited by 312
Self-citationThe role of decidual immune cells on human pregnancy
Liu, S., Diao, L., Huang, C., Li, Y., Zeng, Y., & Kwak-Kim, J. Y. H. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.10.045 · Cited by 308
Metadata
- Authors
- Manaster, I., Mizrahi, S., Goldman-Wohl, D., Sela, H. Y., Stern-Ginossar, N., Lankry, D., Gruda, R., Hurwitz, A., Bdolah, Y., Haimov-Kochman, R., Yagel, S., & Mandelboim, O.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08-01
- Volume
- 181
- Issue
- 3
- Pages
- 1869-1876
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2105101447
- Cited by
- 263
- References
- 44
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Manaster, I., Mizrahi, S., Goldman-Wohl, D., Sela, H. Y., Stern-Ginossar, N., Lankry, D., Gruda, R., Hurwitz, A., Bdolah, Y., Haimov-Kochman, R., Yagel, S., & Mandelboim, O. (2008). Endometrial NK Cells Are Special Immature Cells That Await Pregnancy. The Journal of Immunology. https://doi.org/10.4049/jimmunol.181.3.1869
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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