Uterine NK cells regulate endometrial bleeding in women and are suppressed by the progesterone receptor modulator asoprisnil

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288 · see citing works

The control of the false discovery rate in multiple testing under dependency

Benjamini, Y., & Yekutieli, D. (2001) · The Annals of Statistics · doi:10.1214/aos/1013699998 · Cited by 10,490 · see citing works

Theory and Practice of Histological Techniques

Bancroft, J. D., & Gamble, M. (1990) · Cited by 6,986 · see citing works

Decidual NK cells regulate key developmental processes at the human fetal-maternal interface

Hanna, J. H., Goldman‐Wohl, D., Hamani, Y., Avraham, I., Greenfield, C., Natanson‐Yaron, S., Prus, D., Cohen‐Daniel, L., Arnon, T. I., Manaster, I., et al. (2006) · Nature Medicine · doi:10.1038/nm1452 · Cited by 1,690 · see citing works

Theory and Practice of Histological Techniques

Warren, B. A. (1996) · Pathology · doi:10.1016/s0031-3025(16)35146-7 · Cited by 1,572 · see citing works

Natural killer cells and pregnancy

Moffett-King, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri886 · Cited by 1,235 · see citing works

Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success

Hiby, S. E., Walker, J. J., O’Shaughnessy, K. M., Redman, C. W. G., Carrington, M. N., Trowsdale, J., & Moffett, A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041214 · Cited by 1,122 · see citing works

The estimated annual cost of uterine leiomyomata in the United States

Cardozo, E. R., Clark, A. D., Banks, N., Henne, M. B., Stegmann, B. J., & Segars, J. H. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.12.002 · Cited by 657 · see citing works

Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy

Lash, G. E., Schießl, B., Kirkley, M., Innes, B. A., Cooper, A., Searle, R. F., Robson, S. C., & Bulmer, J. N. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0406250 · Cited by 424 · see citing works

Human uterine leukocytes and pregnancy

Trundley, A., & Moffett, A. (2003) · Tissue Antigens · doi:10.1111/j.1399-0039.2004.00170.x · Cited by 386 · see citing works

Uterine natural killer cells initiate spiral artery remodeling in human pregnancy

Robson, A., Harris, L. K., Innes, B. A., Lash, G. E., Aljunaidy, M. M., Aplin, J., Baker, P. N., Robson, S. C., & Bulmer, J. N. (2012) · The FASEB Journal · doi:10.1096/fj.12-210310 · Cited by 349 · see citing works

Immunocytochemical characterization of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle

King, A., Wellings, V., Gardner, L., & Loke, Y. W. (1989) · Human Immunology · doi:10.1016/0198-8859(89)90060-8 · Cited by 321 · see citing works

IL-15Rα chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation

Mortier, E., Woo, T. T., Advincula, R., Gozalo, S., & Ma, A. I. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071913 · Cited by 316 · see citing works

Angiogenic Growth Factor Messenger Ribonucleic Acids in Uterine Natural Killer Cells

Li, X. F., Jones, D. S., Zhang, E. G., Hiby, S. E., Malik, S., Day, K. A., Licence, D., Bowen, J. M., Gardner, L., King, A., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7418 · Cited by 312 · see citing works

Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis

Chwalisz, K., Perez, M. C., DeManno, D., Winkel, C., Schubert, G., & Elger, W. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0001 · Cited by 310 · see citing works

Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications

Chabbert-Buffet, N., Meduri, G., Bouchard, P., & Spitz, I. M. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi002 · Cited by 310 · see citing works

Steroid receptor expression in uterine natural killer cells

Henderson, T. A., Saunders, P. T. K., Moffett-King, A., Groome, N. P., & Critchley, H. O. D. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021174 · Cited by 283 · see citing works

Human Decidual Natural Killer Cells Express the Receptor for and Respond to the Cytokine Interleukin 151

Verma, S., Hiby, S. E., Loke, Y. W., & King, A. (2000) · Biology of Reproduction · doi:10.1095/biolreprod62.4.959 · Cited by 279 · see citing works

CD3- Leukocytes Present in the Human Uterus During Early Placentation: Phenotypic and MorphologicCharacterization of the CD56++ Population

King, A., Balendran, N., Wooding, P., Carter, N. P., & Loke, Y. W. (1990) · Journal of Immunology Research · doi:10.1155/1991/83493 · Cited by 277 · see citing works

The role of trophoblast in the physiological change in decidual spiral arteries

Kam, E., Gardner, L., Loke, Y. W., & King, A. (1999) · Human Reproduction · doi:10.1093/humrep/14.8.2131 · Cited by 277 · see citing works

Assessment of Requirements for IL-15 and IFN Regulatory Factors in Uterine NK Cell Differentiation and Function During Pregnancy

Ashkar, A. A., Black, G. P., Wei, Q., He, H. G., Liang, L., Head, J. R., & Croy, B. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.2937 · Cited by 257 · see citing works

IL-15 Expression at Human Endometrium and Decidua

Kitaya, K., Yasuda, J., Yagi, I., Tada, Y., Fushiki, S., & Honjo, H. (2000) · Biology of Reproduction · doi:10.1095/biolreprod63.3.683 · Cited by 212 · see citing works

Estrogen Receptor β, But Not Estrogen Receptor α, Is Present in the Vascular Endothelium of the Human and Nonhuman Primate Endometrium1

Critchley, H. O. D., Brenner, R. M., Henderson, T. A., Williams, K., Nayak, N. R., Slayden, O. D., Millar, M. R., & Saunders, P. T. K. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7317 · Cited by 210 · see citing works

Preassociation of IL-15 with IL-15Rα-IgG1-Fc Enhances Its Activity on Proliferation of NK and CD8+/CD44high T Cells and Its Antitumor Action

Dubois, S. P., Patel, H. J., Zhang, M., Waldmann, T. A., & Müller, J. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2099 · Cited by 206 · see citing works

Update on pathways regulating the activation of uterine Natural Killer cells, their interactions with decidual spiral arteries and homing of their precursors to the uterus

Croy, B. A., Esadeg, S., Chantakru, S., van den Heuvel, M., Paffaro, V. A., He, H. G., Black, G. P., Ashkar, A. A., Kiso, Y., & Zhang, J. (2003) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(03)00046-9 · Cited by 198 · see citing works

Immature NK Cells, Capable of Producing IL-22, Are Present in Human Uterine Mucosa

Male, V. H., Hughes, T. L., McClory, S., Colucci, F., Caligiuri, M. A., & Moffett, A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001637 · Cited by 185 · see citing works

The Uterine NK Cell Population Requires IL-15 but These Cells Are Not Required for Pregnancy nor the Resolution of a Listeria monocytogenes Infection

Barber, E. M., & Pollard, J. W. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.37 · Cited by 169 · see citing works

Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions

Chakraborty, D., Rumi, M. A. K., Konno, T., & Soares, M. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109478108 · Cited by 169 · see citing works

Endometrial Morphology After Treatment of Uterine Fibroids With the Selective Progesterone Receptor Modulator, Ulipristal Acetate

Williams, A. R. W., Bergeron, C., Barlow, D. H., & Ferenczy, A. S. (2012) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e318251035b · Cited by 154 · see citing works

Evaluation of oestrogen and progesterone receptor expression in uterine mucosal lymphocytes

King, A., Gardner, L., & Loke, Y. W. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019300 · Cited by 133 · see citing works

Proliferative activity in endometrial stromal granulocytes throughout menstrual cycle and early pregnancy.

Pace, D., Morrison, L., & Bulmer, J. N. (1989) · Journal of Clinical Pathology · doi:10.1136/jcp.42.1.35 · Cited by 125 · see citing works

The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata

Williams, A. R. W., Critchley, H., Osei, J., Ingamells, S., Cameron, I. T., Han, C., & Chwalisż, K. (2007) · Human Reproduction · doi:10.1093/humrep/dem026 · Cited by 122 · see citing works

Progesterone Enhances Interleukin-15 Production in Human Endometrial Stromal Cells in Vitro

Okada, H., Nakajima, T., Sanezumi, M., Ikuta, A., Yasuda, K., & Kanzaki, H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7023 · Cited by 121 · see citing works

Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells

Vacca, P., Cantoni, C., Prato, C., Fulcheri, E., Moretta, A., Moretta, L., & Mingari, M. C. (2008) · International Immunology · doi:10.1093/intimm/dxn105 · Cited by 121 · see citing works

The effect of pregnancy on the uterine NK cell KIR repertoire

Male, V. H., Sharkey, A., Masters, L. M., Kennedy, P. R., Farrell, L. E., & Moffett, A. (2011) · European Journal of Immunology · doi:10.1002/eji.201141445 · Cited by 106 · see citing works

IL-15 Regulation in Human Endometrial Stromal Cells

Dunn, C. L., Critchley, H., & KELLY, R. W. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8539 · Cited by 101 · see citing works

Effects of the Selective Progesterone Receptor Modulator Asoprisnil on Uterine Artery Blood Flow, Ovarian Activity, and Clinical Symptoms in Patients with Uterine Leiomyomata Scheduled for Hysterectomy

Wilkens, J., Chwalisż, K., Han, C., Walker, J., Cameron, I. T., Ingamells, S., Lawrence, A. C., Lumsden, M. A., Hapangama, D. K., Williams, A. R. W., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1104 · Cited by 101 · see citing works

Central Role of Interleukin-15 in Postovulatory Recruitment of Peripheral Blood CD16(−) Natural Killer Cells into Human Endometrium

Kitaya, K., Yamaguchi, T., & Honjo, H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2447 · Cited by 101 · see citing works

Endometrial leucocytes: expression of steroid hormone receptors.

Stewart, J. A., Bulmer, J. N., & Murdoch, A. P. (1998) · Journal of Clinical Pathology · doi:10.1136/jcp.51.2.121 · Cited by 79 · see citing works

Endometrial changes from short-term therapy with CDB-4124, a selective progesterone receptor modulator

Ioffe, O. B., Zaino, R. J., & Mutter, G. L. (2009) · Modern Pathology · doi:10.1038/modpathol.2008.204 · Cited by 69 · see citing works

The effects of 1-month administration of asoprisnil (J867), a selective progesterone receptor modulator, in healthy premenopausal women

Chwalisż, K., Elger, W. A. G., Stickler, T., Mattia‐Goldberg, C., & Larsen, L. M. (2005) · Human Reproduction · doi:10.1093/humrep/deh738 · Cited by 61 · see citing works

Leukocyte Populations and Steroid Receptor Expression in Human First-Trimester Decidua; Regulation by Antiprogestin and Prostaglandin E Analog

Milne, S. A., Henderson, T. A., KELLY, R. W., Saunders, P. T. K., Baird, D. T., & Critchley, H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2338 · Cited by 59 · see citing works

Natural Killer Cells in Human Pregnancy

Male, V. H., Trundley, A., Gardner, L., Northfield, J., Chang, C., Apps, R., & Moffett, A. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-362-6_30 · Cited by 47 · see citing works

Evidence of prokineticin dysregulation in fallopian tube from women with ectopic pregnancy

Shaw, J. L. V., Denison, F. C., Evans, J., Durno, K., Williams, A. R. W., Entrican, G., Critchley, H., Jabbour, H. N., & Horne, A. W. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.10.061 · Cited by 47 · see citing works

IL-15R -IgG1-Fc Enhances IL-2 and IL-15 Anti-tumor Action through NK and CD8+ T Cells Proliferation and Activation

Wu, Z., & Xu, Y. (2010) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq012 · Cited by 39 · see citing works

Menopausal Hormone Therapy and Irregular Endometrial Bleeding: A Potential Role for Uterine Natural Killer Cells?

Hickey, M., Crewe, J., Goodridge, J. P., Witt, C. S., Fraser, I. S., Doherty, D. A., Christiansen, F., & Salamonsen, L. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0688 · Cited by 33 · see citing works

Steroid receptors in blood vessels of the rhesus macaque endometrium: a review

Brenner, R., & Slayden, O. D. (2004) · Archivum histologicum japonicum · doi:10.1679/aohc.67.411 · Cited by 32 · see citing works

Effect of asoprisnil on uterine proliferation markers and endometrial expression of the tumour suppressor gene, PTEN

Wilkens, J., Williams, A. R. W., Chwalisż, K., Han, C., Cameron, I. T., & Critchley, H. (2009) · Human Reproduction · doi:10.1093/humrep/den494 · Cited by 25 · see citing works

Uterine fibroid management: From the present to the future

Donnez, J., & Dolmans, M.-M. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw023 · Cited by 780 · see citing works

Physiology of the Endometrium and Regulation of Menstruation

Critchley, H., Maybin, J. A., Armstrong, G. M., & Williams, A. R. W. (2020) · Physiological Reviews · doi:10.1152/physrev.00031.2019 · Cited by 552 · see citing works

Emerging insights into natural killer cells in human peripheral tissues

Björkström, N. K., Ljunggren, H., & Michaëlsson, J. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.34 · Cited by 451 · see citing works

The Natural Cytotoxicity Receptors in Health and Disease

Barrow, A. D., Martin, C. J., & Colonna, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00909 · Cited by 370 · see citing works

Menstrual physiology: implications for endometrial pathology and beyond

Maybin, J. A., & Critchley, H. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv038 · Cited by 344 · see citing works

Developmental and Functional Control of Natural Killer Cells by Cytokines

Wu, Y., Tian, Z., & Wei, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00930 · Cited by 269 · see citing works

First do no harm: uterine natural killer (NK) cells in assisted reproduction

Moffett, A., & Shreeve, N. (2015) · Human Reproduction · doi:10.1093/humrep/dev098 · Cited by 203 · see citing works

Co‐evolution of NK receptors and HLA ligands in humans is driven by reproduction

Moffett, A., & Colucci, F. (2015) · Immunological Reviews · doi:10.1111/imr.12323 · Cited by 174 · see citing works

Composition, Development, and Function of Uterine Innate Lymphoid Cells

Doisne, J., Balmas, E., Boulenouar, S., Gaynor, L. M., Kieckbusch, J., Gardner, L., Hawkes, D., Barbara, C., Sharkey, A., Brady, H. J. M., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500689 · Cited by 170 · see citing works

Immune determinants of endometrial receptivity: a biological perspective

Robertson, S. A., Moldenhauer, L. M., Green, E. S., Care, A. S., & Hull, M. L. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.04.023 · Cited by 158 · see citing works

Local immune recognition of trophoblast in early human pregnancy: controversies and questions

Moffett, A., & Shreeve, N. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00777-2 · Cited by 146 · see citing works

Selective Progesterone Receptor Modulators—Mechanisms and Therapeutic Utility

Islam, M. S., Afrin, S., Jones, S. I., & Segars, J. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa012 · Cited by 143 · see citing works

Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy

Strunz, B., Bister, J., Jönsson, H., Filipovic, I., Guterstam, Y. C., Kvedaraite, E., Sleiers, N., Dumitrescu, B., Brännström, M., Lentini, A., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abb7800 · Cited by 133 · see citing works

Biology and pathology of the uterine microenvironment and its natural killer cells

Wang, F., Qualls, A., Marques-Fernandez, L., & Colucci, F. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00739-z · Cited by 132 · see citing works

The Update Immune-Regulatory Role of Pro- and Anti-Inflammatory Cytokines in Recurrent Pregnancy Losses

Yang, X., Tian, Y., Zheng, L., Luu, T. V., & Kwak-Kim, J. Y.-H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010132 · Cited by 138 · see citing works

Uterine natural killer cells: from foe to friend in reproduction

Díaz-Hernández, I., Alecsandru, D., García-Velasco, J. A., & Domı́nguez, F. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa062 · Cited by 132 · see citing works

Organoid systems to study the human female reproductive tract and pregnancy

Alzamil, L., Νικολακοπούλου, Κ., & Turco, M. Y. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0565-5 · Cited by 121 · see citing works

Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy

Li, Q., Sharkey, A., Sheridan, M. A., Magistrati, E., Arutyunyan, A., Huhn, O., Sancho‐Serra, C., Anderson, H. E., McGovern, N. N., Esposito, L., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2023.12.013 · Cited by 120 · see citing works

Selective progesterone receptor modulators (SPRMs) for uterine fibroids

Murji, A., Whitaker, L. H. R., Chow, T., & Sobel, M. L. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010770.pub2 · Cited by 110 · see citing works

Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2

Gibson, D. A., Greaves, E., Critchley, H. O. D., & Saunders, P. T. K. (2015) · Human Reproduction · doi:10.1093/humrep/dev067 · Cited by 108 · see citing works

Innate Immune Cells and Toll-like Receptor–Dependent Responses at the Maternal–Fetal Interface

Olmos‐Ortiz, A., Flores‐Espinosa, P., Mancilla‐Herrera, I., Vega‐Sánchez, R., Dı́az, L., & Zaga‐Clavellina, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153654 · Cited by 99 · see citing works

90 YEARS OF PROGESTERONE: New insights into progesterone receptor signaling in the endometrium required for embryo implantation

DeMayo, F. J., & Lydon, J. P. (2020) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0212 · Cited by 97 · see citing works

Molecular definition of group 1 innate lymphoid cells in the mouse uterus

Filipovic, I., Chiossone, L., Vacca, P., Hamilton, R. S., Ingegnere, T., Doisne, J., Hawkes, D., Mingari, M. C., Sharkey, A., Moretta, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06918-3 · Cited by 95 · see citing works

Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis?

Guo, S., & Groothuis, P. G. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy020 · Cited by 93 · see citing works

How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?

Huhn, O., Zhao, X., Esposito, L., Moffett, A., Colucci, F., & Sharkey, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.607669 · Cited by 94 · see citing works

Innate and Adaptive Immune Systems in Physiological and Pathological Pregnancy

Weng, J., Couture, C., & Girard, S. (2023) · Biology · doi:10.3390/biology12030402 · Cited by 93 · see citing works

Uterine fibroids: an update on current and emerging medical treatment options

Farris, M., Bastianelli, C., Rosato, E., Brosens, I. A., & Benagiano, G. (2019) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s147318 · Cited by 82 · see citing works

Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies

Wagenfeld, A., Saunders, P. T. K., Whitaker, L. H. R., & Critchley, H. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2016.1180368 · Cited by 80 · see citing works

Selective progesterone receptor modulator (SPRM) ulipristal acetate (UPA) and its effects on the human endometrium

Whitaker, L. H. R., Murray, A. A., Matthews, R., Shaw, G., Williams, A. R. W., Saunders, P. T. K., & Critchley, H. O. D. (2017) · Human Reproduction · doi:10.1093/humrep/dew359 · Cited by 77 · see citing works

Natural killer cells in recurrent miscarriage: An overview

Guerrero, B., Hassouneh, F., Delgado, E., Casado, J. G., & Tarazona, R. (2020) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2020.103209 · Cited by 74 · see citing works

The Role of Tumor Necrosis Factor α in the Biology of Uterine Fibroids and the Related Symptoms

Ciebiera, M., Włodarczyk, M., Zgliczyńska, M., Łukaszuk, K., Męczekalski, B., Kobierzycki, C., Łoziński, T., & Jakiel, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123869 · Cited by 67 · see citing works

Diversification and Functional Specialization of Human NK Cell Subsets

Cichocki, F. M., Schlums, H., Theorell, J., Tesi, B., Miller, J. S., Ljunggren, H., & Bryceson, Y. T. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_487 · Cited by 67 · see citing works

Vascular changes in the cycling and early pregnant uterus

Massri, N., Loia, R., Sones, J. L., Arora, R., & Douglas, N. C. (2023) · JCI Insight · doi:10.1172/jci.insight.163422 · Cited by 67 · see citing works

Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders

Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103276 · Cited by 70 · see citing works

Immunogenetic contributions to recurrent pregnancy loss

Grimstad, F. W., & Krieg, S. A. (2016) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-016-0720-6 · Cited by 59 · see citing works

Composition and dynamics of the uterine NK cell KIR repertoire in menstrual blood

Ivarsson, M. A., Stiglund, N., Marquardt, N., Westgren, M., Gidlöf, S. B., & Björkström, N. K. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.50 · Cited by 54 · see citing works

The Development and Diversity of ILCs, NK Cells and Their Relevance in Health and Diseases

Zhang, Y., & Huang, B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5987-2_11 · Cited by 52 · see citing works

Menstrual cycle distribution of uterine natural killer cells is altered in heavy menstrual bleeding

Shivhare, S. B., Bulmer, J. N., Innes, B. A., Hapangama, D. K., & Lash, G. E. (2015) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2015.09.001 · Cited by 49 · see citing works

Interleukin-15 in Outcomes of Pregnancy

Gordon, S. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011094 · Cited by 34 · see citing works

Maternal uterine natural killer cells nurture fetal growth: in medio stat virtus

Colucci, F., & Kieckbusch, J. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.12.009 · Cited by 34 · see citing works

Immunobiology of pregnancy: from basic science to translational medicine

Colamatteo, A., Fusco, C., Micillo, T., D’Hooghe, T., de Candia, P., Alviggi, C., Longobardi, S., & Matarese, G. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.05.009 · Cited by 32 · see citing works

Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials

Stewart, E. A., Diamond, M. P., Williams, A. R. W., Carr, B. R., Myers, E. R., Feldman, R., Elger, W. A. G., Mattia‐Goldberg, C., Schwefel, B., & Chwalisż, K. (2019) · Human Reproduction · doi:10.1093/humrep/dez007 · Cited by 30 · see citing works

Endometrial cytokines in patients with and without endometriosis evaluated for infertility

Jørgensen, H., Fedorcsák, P., Isaacson, K., Tevonian, E. N., Xiao, A., Beste, M. T., Qvigstad, E., Lauffenburger, D. A., & Griffith, L. G. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.11.024 · Cited by 30 · see citing works

Selective progesterone receptor modulators: an update

Benagiano, G., Bastianelli, C., Farris, M., & Brosens, I. A. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.914494 · Cited by 30 · see citing works

Uterine natural killer cell progenitor populations predict successful implantation in women with endometriosis‐associated infertility

Glover, L. E., Crosby, D. A., Thiruchelvam, U., Harmon, C., Chorcora, C. N., Wingfield, M. B., & O’Farrelly, C. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.12817 · Cited by 29 · see citing works

Maternal–Fetal Compatibility in Recurrent Pregnancy Loss

Cuadrado-Torroglosa, I., García-Velasco, J. A., & Alecsandru, D. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13082379 · Cited by 27 · see citing works

Validation of Immune Cell Modules in Multicellular Transcriptomic Data

Pollara, G., Murray, M. J., Heather, J., Byng-Maddick, R., Guppy, N., Ellis, M. J., Turner, C. T., Chain, B., & Noursadeghi, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169271 · Cited by 25 · see citing works

Cortisol regulates the paracrine action of macrophages by inducing vasoactive gene expression in endometrial cells

Thiruchelvam, U., Maybin, J. A., Armstrong, G. M., Greaves, E., Saunders, P. T. K., & Critchley, H. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.5a0215-061rr · Cited by 26 · see citing works

Current and Emerging Medical Treatments for Uterine Fibroids

Chwalisż, K., & Taylor, H. S. (2017) · Seminars in Reproductive Medicine · doi:10.1055/s-0037-1606302 · Cited by 23 · see citing works

Progesterone inactivation in decidual stromal cells: A mechanism for inflammation-induced parturition

DeTomaso, A., Kim, H., Shauh, J., Adulla, A., Zigo, S., Ghoul, M., Presicce, P., Kallapur, S. G., Goodman, W. A., Tilburgs, T., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2400601121 · Cited by 19 · see citing works

NK cell receptor profiling of endometrial and decidual NK cells reveals pregnancy-induced adaptations

Feyaerts, D., Benner, M., Comitini, G., Shadmanfar, W., van der Heijden, O. W. H., Joosten, I., & Molen, R. G. V. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1353556 · Cited by 18 · see citing works

Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials

Hamid, F. A., Abu, M., Karim, A. K. A., Ahmad, M., Aziz, N. A., Kamal, D. A. M., & Mokhtar, M. H. (2022) · Biomedicines · doi:10.3390/biomedicines10071705 · Cited by 17 · see citing works

Characteristics of Peripheral Immune Function in Reproductive Females with Uterine Leiomyoma

Liu, Z.-Q., Lu, M.-Y., Sun, R., Yin, Z., Liu, B., & Wu, Y. (2019) · Journal of Oncology · doi:10.1155/2019/5935640 · Cited by 16 · see citing works

Are different markers of endometrial receptivity telling us different things about endometrial function?

Saxtorph, M. H., Persson, G., Hallager, T., Petersen, K. B., Eriksen, J. O., Larsen, L. G., Macklon, N., & Hviid, T. V. F. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13323 · Cited by 16 · see citing works

Phytoprogestins: Unexplored Food Compounds with Potential Preventive and Therapeutic Effects in Female Diseases

Greco, S., Pellegrino, P., Zannotti, A., Carpini, G. D., Ciavattini, A., dos Reis, F. M., & Ciarmela, P. (2021) · Nutrients · doi:10.3390/nu13124326 · Cited by 14 · see citing works

Histomorphological changes in endometriosis in a patient treated with ulipristal: A case report

Bateman, J., Bougie, O., Singh, S. S., & Islam, S. (2016) · Pathology - Research and Practice · doi:10.1016/j.prp.2016.10.010 · Cited by 13 · see citing works

Female Reproductive Systems: Hormone Dependence and Receptor Expression

Kuan, K., & Saunders, P. T. K. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-11836-4_2 · Cited by 12 · see citing works

Tissue-specific nonheritable influences drive endometrial immune system variation

Bister, J., Filipovic, I., Sun, D., Guterstam, Y. C., Cornillet, M., Ponzetta, A., Michaëlsson, J., Gidlöf, S. B., Ivarsson, M. A., Strunz, B., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adj7168 · Cited by 10 · see citing works

Ultrastructure alteration of decidual natural killer cells in women with unexplained recurrent miscarriage: a possible association with impaired decidual vascular remodelling

Almasry, S. M., Elmansy, R. A., Elfayomy, A. K., & Algaidi, S. A. (2014) · Journal of Molecular Histology · doi:10.1007/s10735-014-9598-8 · Cited by 10 · see citing works

Absence of predictable long-term molecular effect of ulipristal acetate (UPA) on the endometrium

Kolańska, K., Varinot, J., Canlorbe, G., Bergeron, C., MEKINIAN, A., Capmas, P., Koskas, M., Daraï, É., Aractingi, S., Bendifallah, S., et al. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.12.013 · Cited by 9 · see citing works

Endometrial TGFβ signaling fosters early pregnancy development by remodeling the fetomaternal interface

Parks, S. E., Geng, T., & Monsivais, D. (2023) · American Journal of Reproductive Immunology · doi:10.1111/aji.13789 · Cited by 8 · see citing works

Decreased CD56+CD16‐CD94+uNK cells in the mid‐luteal phase in women with recurrent implantation failure are associated with IL‐15 deficiency

Zhang, X., & Wu, X. (2023) · American Journal of Reproductive Immunology · doi:10.1111/aji.13794 · Cited by 8 · see citing works

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

Depierreux, D., Seshadri, E., Shmeleva, E. V., Kieckbusch, J., Hawkes, D., & Colucci, F. (2021) · Journal of Visualized Experiments · doi:10.3791/62670 · Cited by 6 · see citing works

Role of uterine NK cells in pregnancy complication

Sabetkam, S., Rafat, A., Mazloumi, Z., Kalarestaghi, H., Bahramloo, M., Naderali, E., & Asl, K. D. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.155998 · Cited by 5 · see citing works

The immunoregulatory role of progesterone during embryo implantation and pregnancy

Colamatteo, A., Carbone, F., Fusco, C., Russo, C., Micillo, T., Carluccio, D., Rocca, C. L., Zheng, W., Longobardi, S., & Matarese, G. (2026) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2026.02.009 · Cited by 5 · see citing works

Regional Analysis of the Immune Microenvironment in Human Endometrium

Yang, L., Su, Y., Cai, S., Ma, H., Yang, J., Xu, M., Li, Y., Huang, C., Zeng, Y., Li, Q., et al. (2024) · American Journal of Reproductive Immunology · doi:10.1111/aji.13921 · Cited by 5 · see citing works

An integration analysis of mRNAs and miRNAs microarray data to identify key regulators for ovarian endometriosis based on competing endogenous RNAs

Wang, K., Sun, Y. X., Wang, Y., & Liu, L. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.06.046 · Cited by 5 · see citing works

The effect of oral vitamin E supplementation on infertile women: a systematic review and meta-analysis

Wu, J., Yang, D., Cao, L., Luo, J.-Q., Qian, W., Ma, W., & Xia, X. (2021) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog.2021.02.2207 · Cited by 5 · see citing works

Do endometrial immune changes with age prior to menopause compromise fertility in women?

Patel, M. V., Shen, Z., & Wira, C. R. (2022) · Exploration of Immunology · doi:10.37349/ei.2022.00076 · Cited by 5 · see citing works

Physiology of Menstruation

Reavey, J. J., Maybin, J. A., & Critchley, H. (2018) · Wiley eBooks · doi:10.1002/9781119426080.ch3 · Cited by 5 · see citing works

Reconstitution of the uterine immune milieu after uterus or hematopoietic stem cell transplantation

Strunz, B., Ivarsson, M. A., Sun, D., Mayer, C., Ziegenhain, C., Guterstam, Y. C., Solders, M., Mölne, J., Björklund, A. T., Marquardt, N., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.adp2583 · Cited by 3 · see citing works

Exploring the Immune System's Role in Endometriosis: Insights Into Pathogenesis, Pain, and Treatment

Ahmed, R. S., Sherif, M., Alghamdi, M. A., El-Tallawy, S. N., Alzaydan, O. K., Pergolizzi, J. V., Varrassi, G., Zaghra, Z., Abdelsalam, Z. S., Kamal, M. T., et al. (2025) · Cureus · doi:10.7759/cureus.87091 · Cited by 2 · see citing works

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

Depierreux, D., Seshadri, E., Shmeleva, E. V., Kieckbusch, J., Hawkes, D., & Colucci, F. (2021) · Journal of Visualized Experiments · doi:10.3791/62670-v · Cited by 2 · see citing works

Comparative immuno‐profiling of proliferative and disordered proliferative endometrium in anovulatory abnormal uterine bleeding

Mangla, M., Palo, S., Kanikaram, P. K., Shekar, P. R., & Setty, A. (2025) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.70032 · Cited by 2 · see citing works

Natural killer cells in reproduction: Before, during and after pregnancy

Fu, B., & Wei, H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818508-7.00009-9 · Cited by 2 · see citing works

Reconstitution of the uterine immune milieu after transplantationPreprint

Strunz, B., Ivarsson, M. A., Sun, D., Ziegenhain, C., Guterstam, Y. C., Solders, M., Björklund, A. T., Marquardt, N., Kaipe, H., Rådestad, A. F., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.04.583277 · Cited by 2 · see citing works

Uterine natural killer cells and pregnancy outcomes: mechanisms, biomarkers, and therapeutic targets

Dzhegutanov, A. A., Sherysheva, K. A., Mutalipov, A. R., Akhkamova, L. A., Gimazetdinova, R. F., Pyatkova, A. V., Levytchenkova, E. N., Galeev, V. D., Li, V., Zyryanov, A. V., et al. (2025) · Obstetrics Gynecology and Reproduction · doi:10.17749/2313-7347/ob.gyn.rep.2025.674 · Cited by 1 · see citing works

Influence of focused ultrasound ablation of uterine fibroids on endometrial receptivity in women of reproductive age

Мелкозерова, О. А., Shchedrina, I. D., Башмакова, Н. В., Chistyakova, G., & Grishkina, А. А. (2020) · Russian Journal of Human Reproduction · doi:10.17116/repro20202604148 · Cited by 1 · see citing works

Immunomorphological signs of chronic endometritis in patients after failed attempts of auxiliary reproductive technologies

Romanenko, T. G., & Haiduk, A. D. (2022) · Reproductive health of woman · doi:10.30841/2708-8731.3.2022.262368 · Cited by 1 · see citing works

Innate Lymphoid Cells in Reproductive Health and Disease

Colucci, F., & Botta, M. (2025) · European Journal of Immunology · doi:10.1002/eji.70007 · Cited by 1 · see citing works

Natural Killer cells in embryo - implantation

Harsa, R., Nedelea, I., Surcel, M., Stamatian, F. V., & Micu, R. (2019) · ROMANIAN BIOTECHNOLOGICAL LETTERS · doi:10.25083/rbl/24.5/789.797 · Cited by 1 · see citing works

Role of Immunoregulatory Cytokine IL-15 in the Endometrium

Dambaeva, S. V., & Beaman, K. D. (2019) · Springer eBooks · doi:10.1007/978-3-030-28584-5_4 · Cited by 1 · see citing works

Molecular and functional studies on human embryo implantation : targets for infertility and fertility regulation

Boggavarapu, N. R. (2017) · Open Archive (Karolinska Institutet) · Cited by 1 · see citing works

Current Therapies to Improve the Endometrial Receptivity of Patients with Repeated Implantation Failure in IVF-ET

Tong, G. (2019) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2019.22.003790

Two Case Reports of Fibroid Treatment with Ulipristal Acetate Before In Vitro Fertilization

Gastañaga-Holguera, T., González, V. G., Urrutia, M. C., Gesto, I. C., Vidaurreta, M., & García, I. C. (2021) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-021-01003-1

Effects of tocopherol supplementation on endometrial thickness in subfertility patients

Fida, R., Wahab, S., Naz, A., Hira, N. E., Khan, A. M., & Publishing, G. (2023) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns7.14060

Perinatology and reproductology: from research to practice

(2023) · Perinatology and reproductology from research to practice · doi:10.52705/2788-6190-2023-3

Morphological features of erdometrium for women with reproductive losses on a background chronic endometritis

Susidko, O. M. (2023) · Perinatology and reproductology from research to practice · doi:10.52705/2788-6190-2023-03-12

Mechanisms Regulating Endometrial Breakdown and Repair at the Time of Menstruation

Saunders, P. T. K., & Maybin, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21477-6.00144-9

Modulation of Endometrial Receptivity by Immune Cells: Insights into Recurrent Implantation Failure (RIF) and Recurrent Miscarriage – A Narrative Review

(2024) · doi:10.70107/collectjgynecolobstet-art0018

Análise imunológica do endométrio: o que temos de novo?

Vieira, D. S., Samama, M., Crosera, A. M. L. V., Pontes, A. C. R., Ikeda, F., & Ueno, J. (2024) · Femina · doi:10.61622/0100-72545211202404

Endometrial immune profile in postmenopausal women receiving Menopausal Hormone Therapy: the role of lymphocyte subpopulations in the development of abnormal uterine bleeding

Dobrokhotova, Y. E., Safarli, S. E., Ilina, I. Y., Нариманова, М. Р., & Kazieva, M. D. (2025) · Medical alphabet · doi:10.33667/2078-5631-2025-17-56-62

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate ( MEHHP ), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Vafaei, S., Omran, M. M., Yang, Q., Laveaux, S. M., Zota, A. R., Al‐Hendy, A., & Ali, M. K. (2026) · Environmental Toxicology · doi:10.1002/tox.70046

Implantation Failure Linked to Altered Uterine NK Cells in PCOS-Like MicePreprint

Torstensson, S., Lu, H., Zhao, A. Z., Gauthier, C., Eriksson, G., Lindgren, E., Deng, Q., Johansson, M. H., Chambers, B. J., Benrick, A., et al. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6556560

Endometrial Hyperplasia Risk Is Increased by High-Fat Diet Via Estrogen-Driven Stromal Fibroblast Reprogramming Toward a Pro-Fibrotic StatePreprint

Skalski, H. J., Bennett, A. Z., Wood, L. E., Harkins, S. K., Arendt, A. R., Espinosa, A. G. L., Burns, G. W., Paul, E. N., Hostetter, G. H., Becker, K., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.20.713224

Progesterone in recurrent pregnancy loss: from controversial efficacy to mechanism-based patient stratification

Wang, C.-F., Zhang, Y.-F., Li, J.-K., Jiao, X., & Wei, Q. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1778288

Giants in Obstetrics and Gynecology: Hilary O.D. Critchley: a physician-scientist who transformed the understanding of menstruation

Romero, R. J. (2026) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2026.04.004

An integrated multimodal pan-organ atlas of the female reproductive system across the lifespan contextualises gynaecological pathologiesPreprint

Cohen, C. E., Párraga-Leo, A., Rodríguez-Montes, L., Kim, C. E., Moullet, M., Paredes, A., Lorenzi, V., Vilarrasa‐Blasi, R., Predeus, A. V., Polański, K., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.10.731198

Exploring New Treatment Strategies for Endometriosis—Narrative Review

Błaszczak-Świątkiewicz, K., & Oettel, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156750

Gene regulation at the early human maternal–fetal interface

Paredes, A. L., Kim, C. E., & Vento‐Tormo, R. (2026) · Nature Reviews Genetics · doi:10.1038/s41576-026-01014-5

Uncovering the role of IL-15 on uterine NK cells during the menstrual cycle

Fischer, B. (2025) · Uppsala University Publications (Uppsala University)

IL-15 Expression at Human Endometrium and Decidua

Kitaya, K., Yasuda, J., Yagi, I., Tada, Y., Fushiki, S., & Honjo, H. (2000) · Biology of Reproduction · doi:10.1095/biolreprod63.3.683 · Cited by 212 · see citing works

Role of Immunoregulatory Cytokine IL-15 in the Endometrium

Dambaeva, S. V., & Beaman, K. D. (2019) · Springer eBooks · doi:10.1007/978-3-030-28584-5_4 · Cited by 1 · see citing works

Insights into the paracrine effects of uterine natural killer cells

Gong, X., Liu, Y., Chen, Z., XU, C., Lu, Q., & Jin, Z. W. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2626 · Cited by 12 · see citing works

Gene Expression Profiling of the Paracrine Effects of Uterine Natural Killer Cells on Human Endometrial Epithelial Cells

Gong, X., Chen, Z., Liu, Y., Lu, Q., & Jin, Z. W. (2014) · International Journal of Endocrinology · doi:10.1155/2014/393707 · Cited by 15 · see citing works