The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Immunolocalization of Proinflammatory Cytokines in Myometrium, Cervix, and Fetal Membranes During Human Parturition at Term1
Abstract
Each of the proinflammatory cytokines interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor (TNF) alpha has been identified in reproductive tissues during labor. The cellular origin of these cytokines is unclear. The aim of this study was to localize these proinflammatory cytokines in myometrium (upper and lower segment), cervix, and fetal membranes at term. Biopsies were taken from women undergoing cesarean section either before or after the onset of labor. Immunohistochemistry was used to localize each of the cytokines IL-1beta, IL-6, IL-8, and TNFalpha. Leukocytes were localized using an antibody to CD45. In myometrium and cervix, immunostaining for IL-1beta was predominantly in leukocytes. In fetal membranes, IL-1beta localized to leukocytes and to the stromal cells of the decidua. In myometrium, IL-6, IL-8, and TNFalpha were restricted to leukocytes, which were present in greater numbers in tissue obtained during labor. In cervix, IL-6, IL-8, and TNFalpha localized to leukocytes and glandular and surface epithelium. IL-8 also localized to cervical stromal cells. In fetal membranes, IL-6 and TNFalpha were expressed by decidual stromal cells, infiltrating leukocytes, and extravillous trophoblasts. In membranes, IL-8 localized to leukocytes in the chorion but was not detected in the amnion. In fetal membranes collected at labor, IL-8 was expressed in decidual stromal cells. Infiltrating leukocytes are a major source of cytokines in uterine tissues during labor.
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Cites
Thomson, A. J. (1999) · Human Reproduction · doi:10.1093/humrep/14.1.229 · Cited by 529
Self-citationNorwitz, E. R., Robinson, J. N., & Challis, J. R. G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908263410906 · Cited by 442
Frohm Nilsson, M., Sandstedt, B., Sørensen, O., Weber, G., Borregaard, N., & Ståhle-Bäckdahl, M. (1999) · Infection and Immunity · doi:10.1128/iai.67.5.2561-2566.1999 · Cited by 351
Human cervical ripening, an inflammatory process mediated by cytokines
Sennstrom, M. B. (2000) · Molecular Human Reproduction · doi:10.1093/molehr/6.4.375 · Cited by 279
Tumor necrosis factor, interleukin-1, and interleukin-6 in normal human pregnancy
Opsjøn, S.-L., Wathen, N. C., Tingulstad, S., Wiedswang, G., Sundan, A., Waage, A., & Austgulen, R. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90096-2 · Cited by 274
Interleukin-8 Synthesis and the Onset of Labor
Osmers, R. (1995) · Obstetrics & Gynecology · doi:10.1016/0029-7844(95)93704-4 · Cited by 224
Roberts, A. K., Monzon-Bordonaba, F., Van Deerlin, P. G., Holder, J., Macones, G. A., Morgan, M. A., Strauss, J. F., & Parry, S. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70632-0 · Cited by 207
TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor
Arntzen, K. J., Kjøllesdal, A. M., Halgunset, J., Vatten, L., & Austgulen, R. (1998) · jpme · doi:10.1515/jpme.1998.26.1.17 · Cited by 185
Fortunato, S. J., Menon, R., Swan, K. F., & Menon, R. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70221-1 · Cited by 145
Expression of inflammatory cytokines (interleukin-1β and interleukin-6) in amniochorionic membranes
Menon, R., Swan, K. F., LYDEN, T. W., Rote, N. S., & Fortunato, S. J. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90562-6 · Cited by 128
Cited by
Challis, J. R., Lockwood, C. J., Myatt, L., Norman, J. E., Strauss, J. F., & Petraglia, F. (2009) · Reproductive Sciences · doi:10.1177/1933719108329095 · Cited by 893
Self-citationCervical remodeling during pregnancy and parturition
Timmons, B., Akins, M., & Mahendroo, M. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.01.011 · Cited by 360
You, X., Liu, J., Xu, C., Liu, W., Zhu, X., Li, Y., Sun, Q., Gu, H., & Ni, X. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3366 · Cited by 56
Peroxisome Proliferator–Activated Receptor Alpha Expression Changes in Human Pregnant Myometrium
Dong, K., Zhang, M.-X., Liu, Y., Su, X.-L., Chen, B., & Zhang, X.-L. (2013) · Reproductive Sciences · doi:10.1177/1933719112461187 · Cited by 9
Metadata
- Authors
- Young, A., Thomson, A. J., Ledingham, M., Jordan, F., Greer, I. A., & Norman, J. E.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-02-01
- Volume
- 66
- Issue
- 2
- Pages
- 445-449
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2168878247
- Cited by
- 361
- References
- 22
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Immunolocalization of Proinflammatory Cytokines in Myometrium, Cervix, and Fetal Membranes During Human Parturition at Term1. https://app.cochat.ai/papers/10.1095/biolreprod66.2.445
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- Young, A., Thomson, A. J., Ledingham, M., Jordan, F., Greer, I. A., & Norman, J. E. (2002). Immunolocalization of Proinflammatory Cytokines in Myometrium, Cervix, and Fetal Membranes During Human Parturition at Term1. Biology of Reproduction. https://doi.org/10.1095/biolreprod66.2.445
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