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Increased brain damage after stroke or excitotoxic seizures in melatonin‐deficient rats
Abstract
The pineal hormone melatonin is neuroprotective in vitro, and in vivo it is neuropro‐ tective when given in pharmacological doses. Conse‐quently, it has been hypothesized that with aging, as circulating levels of melatonin in mammals normally decrease, the brain might be at increased risk of neurodegeneration. However, direct evidence that melatonin deficiency leads to increased brain vulnerability is still lacking. We created melatonin deficiency in rats by pinealectomy and induced neurodegeneration by two models of focal brain ischemia/stroke and by glutamate receptor‐medi‐ ated, epilepsy‐like seizures. We observed greater neurodegeneration in melatonin‐deficient animals than in controls. Our results suggest that endogenous melatonin may play a neuroprotective role, and that melatonin deficiency might be a pathophysiological mechanism in neurodegenerative diseases.—Manev, H., Uz, T., Kharlamov, A., Joo, J.‐Y. Increased brain damage after stroke or excitotoxic seizures in mela‐ tonin‐deficient rats. FASEB J. 10, 1546‐1551
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Cited by
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Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843
Reiter, R. J., Tan, D.-X., Manchester, L. C., & Qi, W. (2001) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:34:2:237 · Cited by 696
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Gilgun-Sherki, Y., Rosenbaum, Z., Melamed, E., & Offen, D. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.271 · Cited by 568
Role of oxidative stress in epileptic seizures
Shin, E.-J., Jeong, J. H., Chung, Y. H., Kim, W.-K., Ko, K.-H., Bach, J.-H., Hong, J.-S., Yoneda, Y., & Kim, H.-C. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.03.025 · Cited by 422
Pandi-Perumal, S. R., BaHammam, A. S., Brown, G. M., Spence, D. W., Bharti, V. K., Kaur, C., Hardeland, R., & Cardinali, D. P. (2013) · Neurotoxicity Research · doi:10.1007/s12640-012-9337-4 · Cited by 320
Metadata
- Authors
- Manev, H., Uz, T., Kharlamov, A., & Joo, J.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1996-11
- Volume
- 10
- Issue
- 13
- Pages
- 1546-1551
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2117488999
- Cited by
- 204
- References
- 0
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Manev, H., Uz, T., Kharlamov, A., & Joo, J. (1996). Increased brain damage after stroke or excitotoxic seizures in melatonin‐deficient rats. The FASEB Journal. https://doi.org/10.1096/fasebj.10.13.8940301
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