The DOI matches its Crossref record.
Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription
Abstract
The induction of microsomal cyto‐chrome P4501A1 by polycyclic aromatic hydrocarbons represents an interesting response by which mammalian cells adapt to xenobiotic exposure. Enzyme induction reflects increased transcription of the corresponding CYP 1A1 gene. Analyses of the induction mechanism using genetic, biochemical, and molecular biological approaches have revealed a novel transcriptional reguljatory pathway that involves ligand‐dependent heterodimerization between two basic helix‐loop‐helix proteins (the Ah receptor and Arnt), interaction of the heterodimer with a xenobiotic‐responsive enhancer, transmission of the induction signal from the enhancer to the CYP 1A1 promoter, and alterations in chromatin structure. Current techniques permit examination of the induction mechanism in intact cells and analyses of the CYP 1A1 gene in its native chromosomal configuration. Such exneriments generate new insights into the control of mammalian transcription that are of relatively broad interest.—Whitlock, J. P., Jr., Okino, S. T., Dong, L., Ko, H. P., Clarke‐Katzenberg, R., Ma, Q., Li, H. Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription. FASEB J. 10, 809‐818 (1996)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Ligand binding and activation of the Ah receptor
Denison, M. S., Pandini, A., Nagy, S. R., Baldwin, E. P., & Bonati, L. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00063-7 · Cited by 485
Ma, Q., & Whitlock, J. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.8878 · Cited by 417
Self-citationMachala, M., Vondráček, J., Bláha, L., Ciganek, M., & Neča, J. (2001) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00240-6 · Cited by 323
Denison, M. S., & Heath-Pagliuso, S. (1998) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/pl00002973 · Cited by 258
Induction of Phosphoglycerate Kinase 1 Gene Expression by Hypoxia
Li, H., Ko, H. P., & Whitlock, J. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.35.21262 · Cited by 173
Self-citation
Metadata
- Authors
- Jr., J. P. W., Okino, S. T., Dong, U., Ko, H. P., Clarke‐Katzenberg, R., Ma, Q., & Li, H.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1996-06
- Volume
- 10
- Issue
- 8
- Pages
- 809-818
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1485553398
- Cited by
- 248
- References
- 0
- FWCI
- 28.67
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription. https://app.cochat.ai/papers/10.1096/fasebj.10.8.8666157
- The paper
- Jr., J. P. W., Okino, S. T., Dong, U., Ko, H. P., Clarke‐Katzenberg, R., Ma, Q., & Li, H. (1996). Induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription. The FASEB Journal. https://doi.org/10.1096/fasebj.10.8.8666157
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
