Ligand binding and activation of the Ah receptor
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The AhR can bind and be activated by a large number of structurally diverse chemicals.
“While the AhR can bind and be activated by a large number of structurally diverse chemicals (4-6), the highest affinity ligands include halogenated aromatic hydrocarbons (HAHs), such as 2,3,7,8tetrachlorodibenzop -dioxin (TCDD, dioxin), and polycyclic aromatic hydrocarbons (PAHs), both widespread classes of environmental contaminants (4,7).”
From Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis (2007) · cites this paper as [6]
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- Authors
- Denison, M. S., Pandini, A., Nagy, S. R., Baldwin, E. P., & Bonati, L.
- Affiliations
- University of California, Davis (US)
- University of Milano-Bicocca (IT)
- Corresponding author
- Denison, Michael S
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 141
- Issue
- 1-2
- Pages
- 3-24
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W1985754063
- Cited by
- 485
- References
- 153
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 12 · 2023: 16 · 2022: 18 · 2021: 7 · 2020: 18 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 20 · 2015: 16 · 2014: 30 · 2013: 24 · 2012: 30
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5r01es007072-04)
- National Institute of Environmental Health Sciences (ES07059, ES 07685, R01ES007685, ES-07072, ES5707, T32ES007059)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- aryl hydrocarbon receptor, ligand binding, receptor activation, ligand-binding domain, aromatic hydrocarbons, crystal structure, signal transduction, transcription factors
- MeSH terms
- Animals, Binding Sites, Humans, Ligands, Protein Binding, Protein Conformation, Signal Transduction, Receptors, Aryl Hydrocarbon
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