The DOI matches its Crossref record; 199 of the 199 references it cites were found in a registry or an index.
The molecular role of Myc in growth and transformation: recent discoveries lead to new insights
Abstract
A major dilemma facing the Myc researcher is understanding how c‐Myc regulation of gene transcription translates into the proliferative and oncogenic activities mediated by c‐Myc protein. Indeed, much effort has focused on attempting to link c‐Myc activation of gene transcription with both cell cycle progression and transformation mechanisms. Considerable progress has been made in recent years, with the identification of new Myc binding proteins as well as novel cellular targets of Myc‐Max complexes. These discoveries have yielded more than a few surprises and challenged those working in the field to rethink traditional paradigms. It is now evident that c‐Myc can also repress the transcription of specific genes, and Myc‐mediated repression appears to be linked to Myc‐dependent transformation. We summarize the evidence on Myc biological and molecular functions with regard to Myc‐Max transcriptional regulation. In addition, we reevaluate current models of Myc transcriptional modulation in light of the discovery of new Myc binding partners and novel downstream target genes. Finally, we explore whether direct transactivation of cellular genes by Myc‐Max heterodimers is sufficient for the growth‐promoting and transforming activities of Myc or whether other molecular activities of Myc, such as Myc‐mediated repression, may play a key role.—Facchini, L. M., Penn, L. Z. The molecular role of Myc in growth and transformation: recent discoveries lead to new insights. FASEB J. 12, 633–651 (1998)
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Cites
Induction of apoptosis in fibroblasts by c-myc protein
Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,935
Self-citationTumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
Kelly, K., Cochran, B. H., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,296
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/318533a0 · Cited by 1,779
Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc
Blackwood, E. M., & Eisenman, R. N. (1991) · Science · doi:10.1126/science.2006410 · Cited by 1,697
Ruley, H. E. (1983) · Nature · doi:10.1038/304602a0 · Cited by 1,248
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J., & Evan, G. (1997) · Nature · doi:10.1038/385544a0 · Cited by 1,148
c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth
Shim, H., Dolde, C., Lewis, B. C., Wu, C.-S., Dang, G., Jungmann, R. A., Dalla-Favera, R., & Dang, C. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6658 · Cited by 1,092
Apoptotic cell death induced by c-myc is inhibited by bcl-2
Bissonnette, R. P., Echeverri, F., Mahboubi, A., & Green, D. R. (1992) · Nature · doi:10.1038/359552a0 · Cited by 957
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap
Lazaris-Karatzas, A., Montine, K. S., & Sonenberg, N. (1990) · Nature · doi:10.1038/345544a0 · Cited by 956
Cited by
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
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Reflecting on 25 years with MYC
Meyer, N., & Penn, L. Z. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2231 · Cited by 1,575
Self-citationThe Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior
Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
Elenbaas, B., Spirio, L., Koerner, F., Fleming, M. D., Zimonjic, D. B., Donaher, J. L., Popescu, N. C., Hahn, W. C., & Weinberg, R. A. (2001) · Genes & Development · doi:10.1101/gad.828901 · Cited by 878
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc
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Metadata
- Authors
- Facchini, L. M., & Penn, L. Z.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1998-06
- Volume
- 12
- Issue
- 9
- Pages
- 633-651
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1953035097
- Cited by
- 377
- References
- 199
- FWCI
- 17.30
- Type
- journal article
- Language
- en
- Open access
- closed
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