The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Amphetamines induce apoptosis and regulation of bcl‐x splice variants in neocortical neurons
Abstract
Amphetamine analogs have emerged as popular recreational drugs of abuse. The number of reports of these substances producing severe acute toxicity and death is increasing. In ‘Ecstasy’ ‐associated deaths, focal necrosis in the liver and individual myocytic necrosis has been reported. Furthermore, serotonergic and dopaminergic neuronal cell damage has been observed in experimental amphetamine intoxication in laboratory animals. Here we demonstrate that subchronic exposure to D‐amphetamine, methamphetamine, methylenedioxyamphetamine, and methylenedioxymethamphetamine (‘Ecstasy’) results in significant neurotoxicity in rat neocortical neurons in vitro . This neuronal cell death is accompanied by endonucleosomal DNA cleavage and differential expression of anti‐ and proapoptotic bcl‐x L/S splice variants. In addition, we observed pronounced induction of cell stress‐associated transcription factor c‐jun and translation initiation inhibitor p97 after amphetamine treatment. These data support that the neurotoxic effects of different amphetamines are extended to rat neocortical neurons and that apoptotic pathways are involved in amphetamine‐induced neurotoxicity.—Stumm, G., Schlegel, J., Schäfer, T., Würz, C., Mennel, H. D., Krieg, J.‐C., Vedder, H. Amphetamines induce apoptosis and regulation of bcl‐x splice variants in neocortical neurons. FASEB J. 13, 1065–1072 (1999)
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Robinson, T. E., & Kolb, B. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08491.1997 · Cited by 704
Vedder, H., Weiβ, I., Holsboer, F., & Reul, J. M. H. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91351-r · Cited by 46
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Cited by
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YELLON, D. M., & DOWNEY, J. M. (2003) · Physiological Reviews · doi:10.1152/physrev.00009.2003 · Cited by 1,062
Toxicity of amphetamines: an update
Carvalho, M., Carmo, H., Costa, V. M., Capela, J. P., Pontes, H., Remião, F., Carvalho, F., & Bastos, M. D. L. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0815-5 · Cited by 431
Cadet, J. L., Jayanthi, S., & Deng, X. (2003) · The FASEB Journal · doi:10.1096/fj.03-0073rev · Cited by 286
Neurotoxicity of substituted amphetamines: Molecular and cellular mechanisms
Cadet, J. L., Krasnova, I. N., Jayanthi, S., & Lyles, J. (2007) · Neurotoxicity Research · doi:10.1007/bf03033567 · Cited by 272
Dietrich, J.-B., Mangeol, A., Revel, M.-O., Burgun, C., Aunis, D., & Zwiller, J. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.018 · Cited by 168
Metadata
- Authors
- Stumm, G., Schlegel, J., Schäfer, T., Würz, C., Mennel, H. D., Krieg, J. ‐., & Vedder, H.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1999-06
- Volume
- 13
- Issue
- 9
- Pages
- 1065-1072
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1610329392
- Cited by
- 177
- References
- 2
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stumm, G., Schlegel, J., Schäfer, T., Würz, C., Mennel, H. D., Krieg, J. ‐., & Vedder, H. (1999). Amphetamines induce apoptosis and regulation of bcl‐x splice variants in neocortical neurons. The FASEB Journal. https://doi.org/10.1096/fasebj.13.9.1065
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