The DOI matches its Crossref record.
Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration
Abstract
Adult rat hepatocytes cultured in a collagen sandwich system maintained normal morphology and a physiological rate of albumin secretion for at least 42 days. Hepatocytes cultured on a single layer of collagen gel essentially ceased albumin secretion within 1 wk but could recover function with the overlay of a second layer of collagen gel. This culture configuration more closely mimics the hepatocytes' in vivo environment and provides a simple method for their long‐term maintenance.— D unn , J. C. Y.; Y armush , M. L.; K oebe , H. G.; T ompkins , R. G. Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration. FASEB J. 3: 174‐177; 1989.
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Cited by
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Wilkening, S., Stahl, F., & Bader, A. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.8.1035 · Cited by 794
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TUMA, P. L., & HUBBARD, A. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00001.2003 · Cited by 681
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Tarlow, B. D., Pelz, C., Naugler, W. E., Wakefield, L., Wilson, E. M., Finegold, M. J., & Grompe, M. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.09.008 · Cited by 533
Metadata
- Authors
- Dunn, J. C. Y., Yarmush, M. L., Koebe, H. G., & Tompkins, R. G.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1989-02
- Volume
- 3
- Issue
- 2
- Pages
- 174-177
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1532411911
- Cited by
- 739
- References
- 0
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration. https://app.cochat.ai/papers/10.1096/fasebj.3.2.2914628
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- Dunn, J. C. Y., Yarmush, M. L., Koebe, H. G., & Tompkins, R. G. (1989). Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration. The FASEB Journal. https://doi.org/10.1096/fasebj.3.2.2914628
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
