Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

Matrix elasticity directs stem cell lineage specification

Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915 · see citing works

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works

Cell Migration: Integrating Signals from Front to Back

Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R., Ginsberg, M. H., Borisy, G. G., Parsons, J. T., & Horwitz, A. R. (2003) · Science · doi:10.1126/science.1092053 · Cited by 4,929 · see citing works

Geometric Control of Cell Life and Death

Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,628 · see citing works

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551 · see citing works

Integrins: A family of cell surface receptors

HYNES, R. (1987) · Cell · doi:10.1016/0092-8674(87)90233-9 · Cited by 4,294 · see citing works

Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment

McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K., & Chen, C. S. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00075-9 · Cited by 4,182 · see citing works

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101 · see citing works

Tensional homeostasis and the malignant phenotype

Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941 · see citing works

Cell Migration: A Physically Integrated Molecular Process

Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915 · see citing works

Fabrication of novel biomaterials through molecular self-assembly

Zhang, S. (2003) · Nature Biotechnology · doi:10.1038/nbt874 · Cited by 3,353 · see citing works

Designing materials for biology and medicine

Langer, R., & Tirrell, D. A. (2004) · Nature · doi:10.1038/nature02388 · Cited by 3,198 · see citing works

Taking Cell-Matrix Adhesions to the Third Dimension

Cukierman, E., Pankov, R., Stevens, D. R., & Yamada, K. M. (2001) · Science · doi:10.1126/science.1064829 · Cited by 3,027 · see citing works

Soft Lithography in Biology and Biochemistry

Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X., & Ingber, D. E. (2001) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.3.1.335 · Cited by 2,603 · see citing works

Environmental sensing through focal adhesions

Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543 · see citing works

Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels

Benya, P. D., & Shaffer, J. D. (1982) · Cell · doi:10.1016/0092-8674(82)90027-7 · Cited by 2,284 · see citing works

Capturing complex 3D tissue physiology in vitro

Griffith, L. G., & Swartz, M. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1858 · Cited by 2,274 · see citing works

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

Burridge, K., Fath, K. R., Kelly, T. J., Nuckolls, G. H., & Turner, C. E. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.002415 · Cited by 2,120 · see citing works

Cells lying on a bed of microneedles: An approach to isolate mechanical force

Tan, J. L., Tien, J., Pirone, D. M., Gray, D. S., Bhadriraju, K., & Chen, C. S. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0235407100 · Cited by 2,036 · see citing works

Molecular regulation of angiogenesis and lymphangiogenesis

Adams, R. H., & Alitalo, K. K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2183 · Cited by 2,005 · see citing works

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

Debnath, J., Muthuswamy, S. K., & Brugge, J. S. (2003) · Methods · doi:10.1016/s1046-2023(03)00032-x · Cited by 2,001 · see citing works

Geometric cues for directing the differentiation of mesenchymal stem cells

Kilian, K. A., Bugarija, B., Lahn, B. T., & Mrksich, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903269107 · Cited by 1,841 · see citing works

Collagen reorganization at the tumor-stromal interface facilitates local invasion

Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G., & Keely, P. J. (2006) · BMC Medicine · doi:10.1186/1741-7015-4-38 · Cited by 1,804 · see citing works

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748 · see citing works

Multicellular tumor spheroids: An underestimated tool is catching up again

Hirschhaeuser, F., Menne, H., Dittfeld, C., West, J., Mueller-Klieser, W., & Kunz-Schughart, L. A. (2010) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2010.01.012 · Cited by 1,674 · see citing works

Matrigel: Basement membrane matrix with biological activity

Kleinman, H. K., & Martin, G. R. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.05.004 · Cited by 1,673 · see citing works

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

Gilbert, P. M., Havenstrite, K. L., Magnusson, K. E. G., Sacco, A., Leonardi, N. A., Kraft, P., Nguyen, N. K., Thrun, S., Lutolf, M. P., & Blau, H. M. (2010) · Science · doi:10.1126/science.1191035 · Cited by 1,587 · see citing works

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

Huebsch, N., Arany, P. R., Mao, A. S., Shvartsman, D. E., Ali, O. A., Bencherif, S. A., Rivera‐Feliciano, J., & Mooney, D. J. (2010) · Nature Materials · doi:10.1038/nmat2732 · Cited by 1,572 · see citing works

Matrigel: A complex protein mixture required for optimal growth of cell culture

Hughes, C. S., Postovit, L. M., & Lajoie, G. A. (2010) · PROTEOMICS · doi:10.1002/pmic.200900758 · Cited by 1,534 · see citing works

How does the extracellular matrix direct gene expression?

Bissell, M. J., Hall, H. G., & Parry, G. (1982) · Journal of Theoretical Biology · doi:10.1016/0022-5193(82)90388-5 · Cited by 1,522 · see citing works

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.231 · Cited by 1,483 · see citing works

Engineering cell shape and function

Singhvi, R., Kumar, A., Lopez, G. P., Stephanopoulos, G. N., Wang, D. I. C., Whitesides, G. M., & Ingber, D. E. (1994) · Science · doi:10.1126/science.8171320 · Cited by 1,453 · see citing works

Compensation mechanism in tumor cell migration

Wolf, K., Mazo, I. B., Leung, H. C. H., Engelke, K., von Andrian, U. H., Deryugina, E. I., Strongin, A. Y., Bröcker, E., & Friedl, P. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209006 · Cited by 1,392 · see citing works

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346 · see citing works

Stresses at the Cell-to-Substrate Interface during Locomotion of Fibroblasts

Dembo, M., & Wang, Y. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77386-8 · Cited by 1,273 · see citing works

Engineering Substrate Topography at the Micro‐ and Nanoscale to Control Cell Function

Bettinger, C. J., Langer, R., & Borenstein, J. T. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805179 · Cited by 1,258 · see citing works

Activation of Integrin Function by Nanopatterned Adhesive Interfaces

Arnold, M., Cavalcanti‐Adam, E. A., Glass, R., Blümmel, J., Eck, W., Kantlehner, M., Kessler, H., & Spatz, J. P. (2004) · ChemPhysChem · doi:10.1002/cphc.200301014 · Cited by 1,165 · see citing works

Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis

Zaman, M. H., Trapani, L. M., Sieminski, A. L., MacKellar, D. C., Gong, H., Kamm, R. D., Wells, A. H., Lauffenburger, D. A., & Matsudaira, P. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604460103 · Cited by 1,159 · see citing works

From Micro- to Nanofabrication with Soft Materials

Quake, S. R., & Scherer, A. (2000) · Science · doi:10.1126/science.290.5496.1536 · Cited by 1,138 · see citing works

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

Park, J. E., Keller, G. A., & Ferrara, N. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.12.1317 · Cited by 1,123 · see citing works

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

PETERSEN, O. W., Rønnov‐Jessen, L., Howlett, A. R., & Bissell, M. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9064 · Cited by 1,096 · see citing works

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

Fu, J., Wang, Y.-K., Yang, M. T., Desai, R. A., Yu, X., Liu, Z., & Chen, C. S. (2010) · Nature Methods · doi:10.1038/nmeth.1487 · Cited by 1,073 · see citing works

Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture

von der Mark, K., Gauss, V., von der Mark, H., & Müller, P. K. (1977) · Nature · doi:10.1038/267531a0 · Cited by 1,068 · see citing works

Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: Implications for cartilage tissue repair

Kisiday, J. D., Jin, M. M., Kurz, B., Hung, H.-H. K., Semino, C. E., Zhang, S., & Grodzinsky, A. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142309999 · Cited by 1,045 · see citing works

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

Vlodavsky, I., Folkman, J., Sullivan, R., Fridman, R., Ishai-Michaeli, R., Sasse, J., & Klagsbrun, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2292 · Cited by 1,032 · see citing works

Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering

Burdick, J. A., & Anseth, K. S. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00176-x · Cited by 1,008 · see citing works

Focal adhesion regulation of cell behavior

Wozniak, M. A., Modzelewska, K., Kwong, L., & Keely, P. J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.04.007 · Cited by 995 · see citing works

Epithelial contact guidance on well-defined micro- and nanostructured substrates

Teixeira, A. I., Abrams, G. A., Bertics, P. J., Murphy, C. J., & Nealey, P. F. (2003) · Journal of Cell Science · doi:10.1242/jcs.00383 · Cited by 978 · see citing works

Dynamic molecular processes mediate cellular mechanotransduction

Hoffman, B. D., Grashoff, C., & Schwartz, M. A. (2011) · Nature · doi:10.1038/nature10316 · Cited by 956 · see citing works

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

DeForest, C. A., Polizzotti, B. D., & Anseth, K. S. (2009) · Nature Materials · doi:10.1038/nmat2473 · Cited by 845 · see citing works

The interaction of cells and bacteria with surfaces structured at the nanometre scale

Anselme, K., Davidson, P. M., Popa, A., Giazzon, M., Liley, M., & Ploux, L. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.04.001 · Cited by 828 · see citing works

Fibroblast biology in three-dimensional collagen matrices

Grinnell, F. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00057-6 · Cited by 819 · see citing works

Mechanisms of Mechanotransduction

Orr, A. W., Helmke, B. P., Blackman, B. R., & Schwartz, M. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.006 · Cited by 809 · see citing works

β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

Weaver, V. M., Lelièvre, S. A., Lakins, J. N., Chrenek, M. A., Jones, J., Giancotti, F. G., Werb, Z., & Bissell, M. J. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00125-3 · Cited by 794 · see citing works

The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

Debnath, J., Mills, K. R., Collins, N. L., Reginato, M. J., Muthuswamy, S. K., & Brugge, J. S. (2002) · Cell · doi:10.1016/s0092-8674(02)01001-2 · Cited by 763 · see citing works

Morphogen gradient interpretation

Gurdon, J. B., & Bourillot, P.-Y. (2001) · Nature · doi:10.1038/35101500 · Cited by 746 · see citing works

One-dimensional topography underlies three-dimensional fibrillar cell migration

Doyle, A. D., Wang, F. W., Matsumoto, K., & Yamada, K. M. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200810041 · Cited by 736 · see citing works

Hepatocyte function and extracellular matrix geometry: long‐term culture in a sandwich configuration

Dunn, J., Yarmush, M. L., Koebe, H. G., & Tompkins, R. G. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.2.2914628 · Cited by 730 · see citing works

Micropatterning as a tool to decipher cell morphogenesis and functions

Théry, M. (2010) · Journal of Cell Science · doi:10.1242/jcs.075150 · Cited by 730 · see citing works

Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering

Mann, B. K., Gobin, A. S., Tsai, A. T., Schmedlen, R. H., & West, J. L. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00051-5 · Cited by 705 · see citing works

Measurement of mechanical tractions exerted by cells in three-dimensional matrices

Legant, W. R., Miller, J. S., Blakely, B. L., Cohen, D. M., Genin, G. M., & Chen, C. S. (2010) · Nature Methods · doi:10.1038/nmeth.1531 · Cited by 647 · see citing works

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

Emerman, J. T., & Pitelka, D. R. (1977) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02616178 · Cited by 642 · see citing works

Versatile, Fully Automated, Microfluidic Cell Culture System

Gómez-Sjöberg, R., Leyrat, A. A., Pirone, D. M., Chen, C. S., & Quake, S. R. (2007) · Analytical Chemistry · doi:10.1021/ac071311w · Cited by 619 · see citing works

II. Clinical Application

Churchill‐Davidson, I., Sanger, C., & Thomlinson, R. H. (1957) · British Journal of Radiology · doi:10.1259/0007-1285-30-356-406 · Cited by 611 · see citing works

Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures

Nelson, C. M., VanDuijn, M. M., Inman, J. L., Fletcher, D. A., & Bissell, M. J. (2006) · Science · doi:10.1126/science.1131000 · Cited by 610 · see citing works

Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity

Théry, M., Racine, V., Piel, M., Pépin, A., Dimitrov, A., Chen, Y., Sibarita, J., & Bornens, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609267103 · Cited by 593 · see citing works

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

Bashkin, P., Doctrow, S. R., Klagsbrun, M., Svahn, C. M., Folkman, J., & Vlodavsky, I. (1989) · Biochemistry · doi:10.1021/bi00430a047 · Cited by 590 · see citing works

A distinctive role for focal adhesion proteins in three-dimensional cell motility

Fraley, S. I., Feng, Y., Krishnamurthy, R., Kim, D. H., Celedon, A., Longmore, G. D., & Wirtz, D. (2010) · Nature Cell Biology · doi:10.1038/ncb2062 · Cited by 587 · see citing works

Molecularly Engineered PEG Hydrogels: A Novel Model System for Proteolytically Mediated Cell Migration

Raeber, G. P., Lütolf, M. P., & Hubbell, J. A. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.050682 · Cited by 576 · see citing works

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing

Prager‐Khoutorsky, M., Lichtenstein, A., Krishnan, R., Rajendran, K., Mayo, A., Kam, Z., Geiger, B., & Bershadsky, A. D. (2011) · Nature Cell Biology · doi:10.1038/ncb2370 · Cited by 564 · see citing works

Diffusion and Convection in Collagen Gels: Implications for Transport in the Tumor Interstitium

Ramanujan, S., Pluen, A., McKee, T. D., Brown, E. B., Boucher, Y., & Jain, R. K. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)73933-7 · Cited by 554 · see citing works

Three-dimensional cell cultures: from molecular mechanisms to clinical applications

Mueller‐Klieser, W. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.4.c1109 · Cited by 537 · see citing works

Mechanotransduction – a field pulling together?

Chen, C. S. (2008) · Journal of Cell Science · doi:10.1242/jcs.023507 · Cited by 520 · see citing works

Activation of fibroblasts in cancer stroma

Räsänen, K., & Vaheri, A. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.032 · Cited by 499 · see citing works

A Hitchhiker's Guide to Mechanobiology

Eyckmans, J., Boudou, T., Yu, X., & Chen, C. S. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.015 · Cited by 498 · see citing works

Engineering gene expression and protein synthesis by modulation of nuclear shape

Thomas, C. H., Collier, J. H., Sfeir, C. S., & Healy, K. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032668799 · Cited by 483 · see citing works

Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration

Lee, S.-H., Moon, J. J., & West, J. L. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.004 · Cited by 413 · see citing works

Experimental and theoretical study of mitotic spindle orientation

Théry, M., Jiménez-Dalmaroni, A., Racine, V., Bornens, M., & Jülicher, F. (2007) · Nature · doi:10.1038/nature05786 · Cited by 406 · see citing works

Anisotropic mechanosensing by mesenchymal stem cells

Kurpinski, K. T., Chu, J. S. F., Hashi, C. K., & Li, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604182103 · Cited by 393 · see citing works

Understanding the biology of angiogenesis: Review of the most important molecular mechanisms

Otrock, Z. K., Mahfouz, R. A., Makarem, J. A., & Shamseddine, A. I. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.04.001 · Cited by 390 · see citing works

Stem Cell Shape Regulates a Chondrogenic Versus Myogenic Fate Through Rac1 and N-Cadherin

Gao, L., McBeath, R., & Chen, C. S. (2010) · Stem Cells · doi:10.1002/stem.308 · Cited by 369 · see citing works

Biological applications of microfluidic gradient devices

Kim, S., Kim, H. J., & Jeon, N. L. (2010) · Integrative Biology · doi:10.1039/c0ib00055h · Cited by 366 · cited 1× · see citing works

The Dynamics and Mechanics of Endothelial Cell Spreading

Reinhart‐King, C. A., Dembo, M., & Hammer, D. A. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.054320 · Cited by 366 · see citing works

Transforming growth factor β type 1 binds to collagen IV of basement membrane matrix: Implications for development

Paralkar, V. M., Vukičević, S., & Reddi, A. H. (1991) · Developmental Biology · doi:10.1016/0012-1606(91)90081-d · Cited by 352 · see citing works

Integrins and cadherins join forces to form adhesive networks

Weber, G. F., Bjerke, M. A., & DeSimone, D. W. (2011) · Journal of Cell Science · doi:10.1242/jcs.064618 · Cited by 345 · see citing works

Two‐Component Polymer Scaffolds for Controlled Three‐Dimensional Cell Culture

Klein, F., Richter, B., Striebel, T., Franz, C. M., von Freymann, G., Wegener, M., & Bastmeyer, M. (2011) · Advanced Materials · doi:10.1002/adma.201004060 · Cited by 336 · see citing works

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

Salaita, K. S., Nair, P. M., Petit, R. S., Neve, R. M., Das, D., Gray, J. W., & Groves, J. T. (2010) · Science · doi:10.1126/science.1181729 · Cited by 331 · see citing works

Directing cell motions on micropatterned ratchets

Mahmud, G., Campbell, C. J., Bishop, K. J. M., Komarova, Y. A., Chaga, O. Y., Soh, S., Huda, S., Kandere‐Grzybowska, K., & Grzybowski, B. A. (2009) · Nature Physics · doi:10.1038/nphys1306 · Cited by 328 · see citing works

Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrata.

Lee, E. Y., Parry, G., & Bissell, M. J. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.98.1.146 · Cited by 322 · see citing works

RhoA/ROCK Signaling Regulates Sox9 Expression and Actin Organization during Chondrogenesis

Woods, A., Wang, G., & Beier, F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409158200 · Cited by 307 · see citing works

Preparation of extracellular matrices produced by cultured and primary fibroblasts

Franco-Barraza, J., Beacham, D. A., Amatangelo, M., & Cukierman, E. (2006) · Current Protocols in Cell Biology · doi:10.1002/cpcb.2 · Cited by 297 · see citing works

Quantifying cellular traction forces in three dimensions

Maskarinec, S. A., Franck, C., Tirrell, D. A., & Ravichandran, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904565106 · Cited by 297 · see citing works

Hypoxia in Static and Dynamic 3D Culture Systems for Tissue Engineering of Bone

Volkmer, E., Drosse, I., Otto, S., Stangelmayer, A., Stengele, M., Kallukalam, B. C., Mutschler, W., & Schieker, M. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0231 · Cited by 286 · see citing works

Cell Shape and Phenotypic Expression in Chondrocytes

Glowacki, J., Trepman, E., & Folkman, J. (1983) · Experimental Biology and Medicine · doi:10.3181/00379727-172-41533 · Cited by 285 · see citing works

Patterning network structure to spatially control cellular remodeling and stem cell fate within 3-dimensional hydrogels

Khetan, S., & Burdick, J. A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.035 · Cited by 281 · see citing works

Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors

Beningo, K. A., Dembo, M., & Wang, Y.-L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405747102 · Cited by 269 · see citing works

Geometric Determinants of Directional Cell Motility Revealed Using Microcontact Printing

Brock, A., Chang, E. I., Ho, C., LeDuc, P. R., Jiang, X., Whitesides, G. M., & Ingber, D. E. (2003) · Langmuir · doi:10.1021/la026394k · Cited by 252 · see citing works

Stroma-Derived Three-Dimensional Matrices Are Necessary and Sufficient to Promote Desmoplastic Differentiation of Normal Fibroblasts

Amatangelo, M. D., Bassi, D. E., Klein-Szanto, A. J. P., & Cukierman, E. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62991-4 · Cited by 248 · see citing works

Cell polarity triggered by cell-cell adhesion via E-cadherin

Desai, R. A., Gao, L., Raghavan, S., Liu, W. F., & Chen, C. S. (2009) · Journal of Cell Science · doi:10.1242/jcs.028183 · Cited by 242 · see citing works

Potential for Control of Signaling Pathways via Cell Size and Shape

Meyers, J. R., Craig, J. A., & Odde, D. J. (2006) · Current Biology · doi:10.1016/j.cub.2006.07.056 · Cited by 232 · see citing works

Cell-matrix adhesions in 3D

Harunaga, J. S., & Yamada, K. M. (2011) · Matrix Biology · doi:10.1016/j.matbio.2011.06.001 · Cited by 225 · see citing works

Stromagenesis: The changing face of fibroblastic microenvironments during tumor progression

Beacham, D. A., & Cukierman, E. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.05.003 · Cited by 225 · see citing works

Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels

Connelly, J. T., Garcı́a, A. J., & Levenston, M. E. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.10.006 · Cited by 222 · see citing works

Bioactive hydrogels made from step-growth derived PEG–peptide macromers

Miller, J. S., Shen, C. J., Legant, W. R., Baranski, J. D., Blakely, B. L., & Chen, C. S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.058 · Cited by 215 · see citing works

Changing directions in the study of chemotaxis

Kay, R. R., Langridge, P. D., Traynor, D., & Hoeller, O. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2419 · Cited by 210 · see citing works

Beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

Weaver, V. M., Lelièvre, S. A., Lakins, J. N., Chrenek, M. A., Jones, J., Giancotti, F. G., Werb, Z., & Bissell, M. J. (2002) · University of North Texas Digital Library (University of North Texas) · doi:10.1016/s1535-6108%2802%2900125-3 · Cited by 208 · see citing works

Dendritic Fibroblasts in Three-dimensional Collagen Matrices

Grinnell, F., Ho, C.-H., Tamaríz, E., Lee, D. J., & Skuta, G. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-08-0493 · Cited by 204 · see citing works

Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense α2 integrin mrna in mammary cells

Keely, P. J., Fong, A. M., Zutter, M. M., & Santoro, S. A. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.2.595 · Cited by 204 · see citing works

Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness

Pathak, A., & Kumar, S. (2011) · Integrative Biology · doi:10.1039/c0ib00095g · Cited by 200 · see citing works

Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo

Langevin, H. M., Bouffard, N. A., Badger, G. J., Iatridis, J. C., & Howe, A. K. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00420.2004 · Cited by 196 · see citing works

RhoA/ROCK Signaling Regulates Chondrogenesis in a Context-dependent Manner

Woods, A., & Beier, F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509433200 · Cited by 189 · see citing works

Culture of chondrocytes in alginate and collagen carrier gels

van Susante, J. L. C., Buma, P., van Osch, G. J. V. M., Versleyen, D., van der Kraan, P. M., Berg, W. B. V. D., & Homminga, G. N. (1995) · Acta Orthopaedica Scandinavica · doi:10.3109/17453679509002314 · Cited by 183 · see citing works

Reducing background fluorescence reveals adhesions in 3D matrices

Kubow, K. E., & Horwitz, A. R. (2010) · Nature Cell Biology · doi:10.1038/ncb0111-3 · Cited by 165 · see citing works

Use of nanotopography to study mechanotransduction in fibroblasts – methods and perspectives

Dalby, M. J., Riehle, M. O., Sutherland, D. S., Agheli, H., & Curtis, A. S. G. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00369 · Cited by 150 · see citing works

Micropatterning of bioactive self-assembling gels

Mata, Á., Hsu, L., Capito, R. M., Aparicio, C., Henrikson, K. J., & Stupp, S. I. (2009) · Soft Matter · doi:10.1039/b819002j · Cited by 141 · see citing works

Precision of the Dpp gradient

Bollenbach, T., Pantazis, P., Kicheva, A., Bökel, C., González‐Gaitán, M., & Jülicher, F. (2008) · Development · doi:10.1242/dev.012062 · Cited by 133 · see citing works

The Chondrocyte Cytoskeleton in Mature Articular Cartilage: Structure and Distribution of Actin, Tubulin, and Vimentin Filaments

Langelier, È., Suetterlin, R., Hoemann, C. D., et al. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004801002 · Cited by 125 · see citing works

Proteoglycan and collagen synthesis are correlated with actin organization in dedifferentiating chondrocytes.

Mallein‐Gérin, F., Garrone, R., & van der Rest, M. (1991) · PubMed · Cited by 119 · see citing works

Signal dynamics in Sonic hedgehog tissue patterning

Saha, K., & Schaffer, D. V. (2006) · Development · doi:10.1242/dev.02254 · Cited by 118 · see citing works

Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis

Manjón, C., Sánchez‐Herrero, E., & Suzanne, M. (2006) · Nature Cell Biology · doi:10.1038/ncb1518 · Cited by 112 · see citing works

ADF/cofilin family proteins control formation of oriented actin-filament bundles in the cell body to trigger fibroblast polarization

Mseka, T., BAMBURG, J., & Cramer, L. P. (2007) · Journal of Cell Science · doi:10.1242/jcs.017640 · Cited by 96 · see citing works

Biological applications of microfluidics

Gomez, F. A. (2008) · Cited by 94 · see citing works

Mechano-topographic modulation of stem cell nuclear shape on nanofibrous scaffolds

Nathan, A. S., Baker, B. M., Nerurkar, N. L., et al. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.08.007 · Cited by 94 · see citing works

Preparation of Extracellular Matrices Produced by Cultured and Primary Fibroblasts

Beacham, D. A., Amatangelo, M. D., & Cukierman, E. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb1009s33 · Cited by 91 · see citing works

Collagenous substrata regulate the nature and distribution of glycosaminoglycans produced by differentiated cultures of mouse mammary epithelial cells

Parry, G., Lee, E., Farson, D., Koval, M. H., & Bissell, M. J. (1985) · Experimental Cell Research · doi:10.1016/0014-4827(85)90556-7 · Cited by 85 · see citing works

High-Throughput Screening for Modulators of Mesenchymal Stem Cell Chondrogenesis

Huang, A. H., Motlekar, N. A., Stein-Merlob, A. F., Diamond, S. L., Shore, E. M., & Mauck, R. L. (2008) · Annals of Biomedical Engineering · doi:10.1007/s10439-008-9562-4 · Cited by 82 · see citing works

Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling

Niklason, L. E., Yeh, A. T., Calle, E. A., Bai, Y., Valentín, A., & Humphrey, J. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907813106 · Cited by 77 · see citing works

Understanding microchannel culture: parameters involved in soluble factor signaling

Yu, H., Alexander, C. M., & Beebe, D. J. (2007) · Lab on a Chip · doi:10.1039/b618793e · Cited by 74 · see citing works

Transfer of Macroscale Tissue Strain to Microscale Cell Regions in the Deformed Meniscus

Upton, M. L., Gilchrist, C. L., Guilak, F., et al. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.126938 · Cited by 65 · see citing works

Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis

Raghavan, S., Shen, C. J., Desai, R. A., Sniadecki, N. J., Nelson, C. M., & Chen, C. S. (2010) · Journal of Cell Science · doi:10.1242/jcs.055079 · Cited by 54 · see citing works

Fiber Stretch and Reorientation Modulates Mesenchymal Stem Cell Morphology and Fibrous Gene Expression on Oriented Nanofibrous Microenvironments

Heo, S.-J., Nerurkar, N. L., Baker, B. M., et al. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0365-7 · Cited by 53 · see citing works

Surface area regulation: underexplored yet crucial in cell motility

Kay, R. R., Langridge, P. D., Traynor, D., et al. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2419-c2 · Cited by 36 · see citing works

Reconstructing the third dimension

Saldin, D. K. (2012) · Nature · doi:10.1038/486197a · Cited by 4 · see citing works

Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors

Edmondson, R., Broglie, J. J., Adcock, A. F., & Yang, L. (2014) · ASSAY and Drug Development Technologies · doi:10.1089/adt.2014.573 · Cited by 2,515 · see citing works

Effects of extracellular matrix viscoelasticity on cellular behaviour

Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224 · see citing works

A practical guide to hydrogels for cell culture

Caliari, S. R., & Burdick, J. A. (2016) · Nature Methods · doi:10.1038/nmeth.3839 · Cited by 2,075 · see citing works

Modeling physiological events in 2D vs. 3D cell culture

Duval, K., Grover, H., Han, L.-H., Mou, Y., Pegoraro, A. F., Fredberg, J., & Chen, Z. (2017) · Physiology · doi:10.1152/physiol.00036.2016 · Cited by 1,849 · see citing works

2D and 3D Cell Cultures - a Comparison of Different Types of Cancer Cell Cultures

Kapałczyńska, M., Kolenda, T., Przybyła, W., Zajączkowska, M., Teresiak, A., Filas, V., Ibbs, M., Bliźniak, R., Łuczewski, Ł., & Lamperska, K. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.63743 · Cited by 1,499 · see citing works

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

Zanoni, M., Piccinini, F., Arienti, C., Zamagni, A., Santi, S., Polico, R., Bevilacqua, A., & Tesei, A. (2016) · Scientific Reports · doi:10.1038/srep19103 · Cited by 1,144 · see citing works

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

Nath, S., & Devi, G. R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.03.013 · Cited by 919 · see citing works

Role of the extracellular matrix in regulating stem cell fate

Watt, F. M., & Huck, W. T. S. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3620 · Cited by 861 · see citing works

Extracellular matrix-based materials for regenerative medicine

Hussey, G. S., Dziki, J. L., & Badylak, S. F. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0023-x · Cited by 844 · see citing works

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Nunes, A. S., Barros, A. S., Costa, E. C., Moreira, A. F., & Correia, I. J. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.26845 · Cited by 721 · see citing works

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

Shamir, E. R., & Ewald, A. J. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3873 · Cited by 719 · see citing works

3D biofabrication strategies for tissue engineering and regenerative medicine

Bajaj, P., Schweller, R. M., Khademhosseini, A., West, J. L., & Bashir, R. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-105155 · Cited by 632 · see citing works

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

Baker, B. M., Trappmann, B., Wang, W. Y., Sakar, M. S., Kim, I. L., Shenoy, V. B., Burdick, J. A., & Chen, C. S. (2015) · Nature Materials · doi:10.1038/nmat4444 · Cited by 556 · see citing works

Injectable alginate hydrogels for cell delivery in tissue engineering

Bidarra, S. J., Barrias, C. C., & Granja, P. L. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.12.006 · Cited by 534 · see citing works

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

Pinto, B., Henriques, A. C., Silva, P. M. A., & Bousbaa, H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121186 · Cited by 440 · see citing works

The production of 3D tumor spheroids for cancer drug discovery

Sant, S., & Johnston, P. A. (2017) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2017.03.002 · Cited by 404 · see citing works

Liver organoids: from basic research to therapeutic applications

Prior, N., Inacio, P., & Huch, M. (2019) · Gut · doi:10.1136/gutjnl-2019-319256 · Cited by 356 · see citing works

The relevance and potential roles of microphysiological systems in biology and medicine

Wikswo, J. P. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214542068 · Cited by 248 · see citing works

Human airway organoid engineering as a step toward lung regeneration and disease modeling

Tan, Q., Choi, K. M., Sicard, D., & Tschumperlin, D. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.046 · Cited by 191 · see citing works

Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells

Mierke, C. T. (2024) · Cells · doi:10.3390/cells13010096 · Cited by 146 · see citing works

Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture Medium

Lindborg, B. A., Brekke, J. H., Vegoe, A. L., Ulrich, C. B., Haider, K. T., Subramaniam, S., Venhuizen, S. L., Eide, C. R., Orchard, P. J., Chen, W., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0305 · Cited by 141 · see citing works

Tumor cells and their crosstalk with endothelial cells in 3D spheroids

Shoval, H., Karsch-Bluman, A., Brill-Karniely, Y., Stern, T., Zamir, G., Hubert, A., & Benny, O. (2017) · Scientific Reports · doi:10.1038/s41598-017-10699-y · Cited by 138 · see citing works

Hydrogels as artificial matrices for cell seeding in microfluidic devices

Akther, F., Little, P., Li, Z., Nguyen, N.-T., & Ta, H. T. (2020) · RSC Advances · doi:10.1039/d0ra08566a · Cited by 127 · see citing works

Polysaccharide matrices used in 3D in vitro cell culture systems

Diekjürgen, D., & Grainger, D. W. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.020 · Cited by 125 · see citing works

Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

Park, D., Lee, J., Chung, J. J., Jung, Y., & Kim, S. H. (2020) · Trends in Biotechnology · doi:10.1016/j.tibtech.2019.06.006 · Cited by 105 · see citing works

Human vascular microphysiological system for in vitro drug screening

Fernandez, C. E., Yen, R. W., Perez, S. M., Bedell, H. W., Povsic, T. J., Reichert, W. M., & Truskey, G. A. (2016) · Scientific Reports · doi:10.1038/srep21579 · Cited by 93 · see citing works

In vitro modeling of the prostate cancer microenvironment

Ellem, S. J., De-Juan-Pardo, E. M., & Risbridger, G. P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.04.008 · Cited by 68 · see citing works

Acoustofluidic assembly of 3D neurospheroids to model Alzheimer's disease

Cai, H., Ao, Z., Hu, L., Moon, Y., Wu, Z., Lu, H.-C., Kim, J., & Guo, F. (2020) · The Analyst · doi:10.1039/d0an01373k · Cited by 70 · see citing works

Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis

Shah, S., & D’Souza, G. G. M. (2025) · Cells · doi:10.3390/cells14100732 · Cited by 66 · see citing works

An omentum-inspired 3d peg hydrogel for identifying ecm-drivers of drug resistant ovarian cancer

Brooks, E. A., Gencoglu, M. F., Corbett, D. C., Stevens, K. R., & Peyton, S. R. (2019) · APL Bioengineering · doi:10.1063/1.5091713 · Cited by 51 · see citing works

Identification of synergistic drug combinations using breast cancer patient-derived xenografts

Turner, T. H., Alzubi, M. A., & Harrell, J. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-58438-0 · Cited by 50 · see citing works

Developing multi-cellular tumor spheroid model (MCTS) in the chitosan/collagen/alginate (CCA) fibrous scaffold for anticancer drug screening

Wang, J.-Z., Zhu, Y.-X., Ma, H.-C., Chen, S.-N., Chao, J.-Y., Ruan, W.-D., Wang, D., Du, F.-G., & Meng, Y.-Z. (2016) · Materials Science and Engineering: C · doi:10.1016/j.msec.2016.01.045 · Cited by 49 · see citing works

Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression

Maiso, P., Mogollón, P., Ocio, E. M., & Garayoa, M. (2021) · Cancers · doi:10.3390/cancers13112542 · Cited by 48 · see citing works

Patient-specific organotypic blood vessels as an in vitro model for anti-angiogenic drug response testing in renal cell carcinoma

Jiménez-Torres, J. A., Virumbrales-Muñoz, M., Sung, K. E., Lee, M. H., Abel, E. J., & Beebe, D. J. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.026 · Cited by 46 · see citing works

Bioengineered Submucosal Organoids for <i>In Vitro</i> Modeling of Colorectal Cancer

Devarasetty, M., Skardal, A., Cowdrick, K., Marini, F., & Soker, S. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0397 · Cited by 41 · see citing works

Acoustic Droplet-Assisted Superhydrophilic–Superhydrophobic Microarray Platform for High-Throughput Screening of Patient-Derived Tumor Spheroids

Xia, Y., Chen, H., Li, J., Hu, H., Qian, Q., He, R.-X., Ding, Z., & Guo, S.-S. (2021) · ACS Applied Materials &amp; Interfaces · doi:10.1021/acsami.1c06655 · Cited by 35 · see citing works

Assessment of different 3D culture systems to study tumor phenotype and chemosensitivity in pancreatic ductal adenocarcinoma

ZEEBERG, K., CARDONE, R. A., GRECO, M. R., SACCOMANO, M., NØHR-NIELSEN, A., ALVES, F., PEDERSEN, S. F., & RESHKIN, S. J. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3513 · Cited by 33 · see citing works

3D Tumor Spheroid Models for In Vitro Therapeutic Screening of Nanoparticles

Daunys, S., Janonienė, A., Januškevičienė, I., Paškevičiūtė, M., & Petrikaitė, V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-58174-9_11 · Cited by 32 · see citing works

Cytotoxic responses of carnosic acid and doxorubicin on breast cancer cells in butterfly-shaped microchips in comparison to 2D and 3D culture

Yildiz-Ozturk, E., Gulce-Iz, S., Anil, M., & Yesil-Celiktas, O. (2017) · Cytotechnology · doi:10.1007/s10616-016-0062-3 · Cited by 32 · see citing works

Advances in microfluidic 3D cell culture for preclinical drug development

(2022) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2021.07.022 · Cited by 23 · see citing works

Ex Vivo Tools and Models in MASLD Research

Velliou, R.-I., Giannousi, E., Ralliou, C., Kassi, E., & Chatzigeorgiou, A. (2024) · Cells · doi:10.3390/cells13221827 · Cited by 15 · see citing works

Biotechnological advances and applications of human pluripotent stem cell-derived heart models

Muniyandi, P., O’Hern, C., Popa, M. A., & Aguirre, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1214431 · Cited by 14 · see citing works

Microphysiological systems as models for immunologically ‘cold’ tumors

Gaebler, D., Hachey, S. J., & Hughes, C. C. W. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1389012 · Cited by 12 · see citing works

SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden

(2025) · doi:10.1186/s13073-024-01418-0 · Cited by 12 · see citing works

In vitro models of cancer

Boussommier-Calleja, A. (2020) · Bioengineering Innovative Solutions for Cancer · doi:10.1016/b978-0-12-813886-1.00013-9 · Cited by 10 · see citing works

Effects of Mechanotransduction on Stem Cell Behavior

Bilgen, B., & Odabaş, S. (2016) · doi:10.1002/9781119242642.ch3 · Cited by 4 · see citing works

Significance of cell culture phases for utilizing 3D cultures of A549 cells for in vitro studies

Swethaa, N. G., & Ravi, M. (2023) · Cell Biology International · doi:10.1002/cbin.12075 · Cited by 5 · see citing works

An Improved Three-dimensional Cell Culture Model of Human Breast Cancer as Well as Drug Sensitivity Investigation

Runtin, Y. (2014) · Yaoxue jinzhan

Cytotoxicity evaluation of sodium lauryl sulfate in a paper-based 3D cell culture system

Lee, Y. J., Ahn, Y. J., & Lee, G. (2022) · Analytical Methods · doi:10.1039/d2ay00161f · Cited by 3 · see citing works

Development of a micro-scale perfusion 3D cell culture biochip with an incorporated electrical impedance measurement scheme for the quantification of cell number in a 3D cell culture construct

Lei, K. F., Wu, M., Liao, P.-Y., Chen, Y., & Pan, T.-M. (2011) · Microfluidics and Nanofluidics · doi:10.1007/s10404-011-0854-x · Cited by 16 · see citing works