The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Metabolic effects of dietary fructose
Abstract
Fructose, a naturally occurring hexose, is a component of many fruits, vegetables, and sweeteners. Because of the introduction of high fructose corn sweeteners in 1967, the amount of free fructose in the diet of Americans has increased substantially in the last 20 years. Fructose is sweeter, more soluble, and less glucogenic than glucose or sucrose, so it has been recommended as a replacement for these sugars in the diets of diabetic and obese people. Although an acute dose of fructose causes smaller increases in glucose and insulin than a comparable dose of glucose, there are a number of changes after dietary adaptation that may reduce its desirability as a sugar replacement in certain segments of the population. Fructose is absorbed primarily in the jejunum and metabolized in the liver. When consumed in excess of dietary glucose, it may be malabsorbed. Fructose is more lipogenic than glucose or starches, and usually causes greater elevations in triglycerides and sometimes in cholesterol than other carbohydrates. Dietary fructose has resulted in increases in blood pressure, uric acid, and lactic acid. People who are hypertensive, hyperinsulinemic, hypertriglyceridemic, noninsulin‐dependent diabetic, or postmenopausal are more susceptible to these adverse effects of dietary fructose than healthy young subjects. Although consumption of fructose as a component of fruits and vegetables is an unavoidable consequence of eating a healthy diet, added fructose seems to provide little advantage over other caloric sweeteners and compares unfavorably to complex carbohydrates in susceptible segments of the population.— H allfrisch , J. Metabolic effects of dietary fructose. FASEB J. 4: 2652‐2660; 1990.
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Cites
Schaftingen, E. V. (1987) · Advances in Enzymology - and Related Areas of Molecular Biology · doi:10.1002/9780470123058.ch7 · Cited by 336
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Metabolic Effects of Dietary Fructose and Sucrose in Types I and II Diabetic Subjects
Bantle, J. P. (1986) · JAMA · doi:10.1001/jama.1986.03380230065027 · Cited by 145
Fructose: metabolism and short-term effects on carbohydrate and purine metabolic pathways.
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Reassessing the effects of simple carbohydrates on the serum triglyceride responses to fat meals
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Cited by
Johnson, R. J., Segal, M. S., Sautin, Y., Nakagawa, T., Feig, D. I., Kang, D.-H., Gersch, M. S., Benner, S., & Sánchez-Lozada, L. G. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.899 · Cited by 1,075
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat
Park, T. J., Reznick, J., Peterson, B. L., Blass, G., Omerbašić, D., Bennett, N. C., Kuich, P. H. J. L., Zasada, C., Browe, B. M., Hamann, W., et al. (2017) · Science · doi:10.1126/science.aab3896 · Cited by 641
Vos, M. B., Kaar, J. L., Welsh, J. A., Van Horn, L. V., Feig, D. I., Anderson, C. A. M., Patel, M. J., Cruz Munos, J., Krebs, N. F., Xanthakos, S. A., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000439 · Cited by 580
The pathophysiology of hypertension in patients with obesity
DeMarco, V. G., Aroor, A. R., & Sowers, J. R. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.44 · Cited by 545
Nakagawa, T., Tuttle, K. R., Short, R. A., & Johnson, R. J. (2005) · Nature Clinical Practice Nephrology · doi:10.1038/ncpneph0019 · Cited by 382
Metadata
- Authors
- Hallfrisch, J.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1990-06
- Volume
- 4
- Issue
- 9
- Pages
- 2652-2660
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2137988672
- Cited by
- 357
- References
- 18
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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