Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat
Open accessAbstract
Safe anaerobic metabolism: Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with fructose by a rewired pathway that avoids tissue damage (see the Perspective by Storz and McClelland). These results provide insight into the adaptations that this strange social rodent has to make for life underground. They also have implications for medical practice, particularly for understanding how to protect tissues from hypoxia. Science , this issue p. 307 ; see also p. 248
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- Authors
- Park, T. J., Reznick, J., Peterson, B. L., Blass, G., Omerbašić, D., Bennett, N. C., Kuich, P. H. J. L., Zasada, C., Browe, B. M., Hamann, W., Applegate, D. T., Radke, M. H., Kosten, T., Lutermann, H., Gavaghan, V., Eigenbrod, O., Bégay, V., Amoroso, V. G., Govind, V., Minshall, R. D., Smith, E. S. J., Larson, J., Gotthardt, M., Kempa, S., & Lewin, G. R.
- Affiliations
- University of Illinois Chicago (US)
- Max Delbrück Center (DE)
- University of Pretoria (ZA)
- University of Cambridge (GB)
- Corresponding author
- Park, Thomas J.
- Reznick, Jane
- Lewin, Gary R.
- ORCID
- Park, Thomas J.
- Reznick, Jane
- Peterson, Bethany L.
- Blass, Gregory
- Omerbašić, Damir
- Bennett, Nigel C.
- Zasada, Christin
- Browe, Brigitte M.
- Hamann, Wiebke
- Applegate, Daniel T.
- Radke, Michael H.
- Lutermann, Heike
- Gavaghan, Victoria
- Eigenbrod, Ole
- Bégay, Valérie
- Amoroso, Vince G.
- Govind, Vidya
- Minshall, Richard D.
- Smith, Ewan St. J.
- Gotthardt, Michael
- Kempa, Stefan
- Lewin, Gary R.
- Venue
- Science
- Published
- 2017-04-21
- Volume
- 356
- Issue
- 6335
- Pages
- 307-311
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2606455791
- Cited by
- 641
- References
- 0
- Citations by year
- 2026: 42 · 2025: 52 · 2024: 54 · 2023: 59 · 2022: 70 · 2021: 97 · 2020: 87 · 2019: 74 · 2018: 70 · 2017: 34
- FWCI
- 23.72
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- UpSpace Institutional Repository (University of Pretoria) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- National Science Foundation (0744979)
- National Institutes of Health (HL71626 and HL60678)
- European Research Council (294678)
- Deutsche Forschungsgemeinschaft (Go865/9-1, SFB665)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- naked mole-rat, anoxia tolerance, fructose metabolism, glycolysis, hypoxia, anaerobic metabolism, ketohexokinase, lactate, metabolic reprogramming, oxygen deprivation, subterranean mammals
- MeSH terms
- Adaptation, Physiological, Anaerobiosis, Animals, Brain, Fructokinases, Fructose, Glycolysis, Myocardium, Oxygen, Sucrose, Lactic Acid, Mole Rats, Glucose Transporter Type 5, Mice
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