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Cited by 924

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The selecting: vascular adhesion molecules

Tedder, Thomas F., Steeber, Douglas A., Chen, Anjun, Engel, Pablo·1995·The FASEB Journal
DOI 10.1096/fasebj.9.10.7542213
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Abstract

The selectin family of adhesion molecules mediates the initial attachment of leukocytes to venular endothelial cells before their firm adhesion and diapedesis at sites of tissue injury and inflammation. The selectin family consists of three closely related cell‐surface molecules with differential expression by leukocytes (L‐eelectin), platelets (P‐se‐lectin), and vascular endothelium (E‐ and P‐selectin). The selecting have characteristic extracellular regions composed of an amino‐terminal lectin domain that binds a carbohydrate ligand, an epidermal growth factor‐like domain, and two to nine short repeat units homologous to domains found in complement binding proteins. In contrast to most other adhesion molecules, selectin function is restricted to leukocyte interactions with vascular endothelium. Multiple studies indicate that the selectins mediate neutrophil, monocyte, and lymphocyte rolling along the venular wall. The generation of selectin—deficient mice has confirmed these findings and provided further insight into how the overlapping functions of these receptors regulate inflammatory processes. Se‐ lectin‐directed therapeutic agents are now proven to be effective in blocking many of the pathological effects resulting from leukocyte entry into sites of inflammation. Future studies are focused on how the selectins interact with the increasing array of other adhesion molecules and inflammatory mediators.—Tedder, T. F., Steeber, D. A., Chen, A., Engel, P. The selectins: vascular adhesion molecules. FASEB J. 9, 866‐873 (1995)

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Metadata

Authors
Tedder, T. F., Steeber, D. A., Chen, A., & Engel, P.
Venue
The FASEB Journal
Publisher
Wiley
Published
1995-07
Volume
9
Issue
10
Pages
866-873
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fasebj.9.10.7542213
OpenAlex
W2128256270
Cited by
924
References
1
FWCI
19.70
Type
journal article
Language
en
Open access
closed

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