The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
The biochemistry of programmed cell death
Abstract
Programmed cell death (PCD) is involved in the removal of superfluous and damaged cells in most organ systems. The induction phase of PCD or apoptosis is characterized by an extreme heterogeneity of potential PCD‐triggering signal transduction pathways. During the subsequent effector phase, the numerous PCD‐indueing stimuli converge into a few stereotypical pathways and cells pass a point of no return, thus becoming irreversibly committed to death. It is only during the successive degradation phase that vital structures and functions are destroyed, giving rise to the full‐blown phenotype of PCD. Evidence is accumulating that cytoplasmic structures, including mitochondria, participate in the critical effector stage and that alterations commonly considered to define PCD (apoptotic morphology of the nucleus and regular, oligonucleosomal chromatin fragmentation) have to be ascribed to the late degradation phase. The decision as to whether a cell will undergo PCD or not may be expected to be regulated by “switches” that, once activated, trigger self‐am‐ plificatory metabolic pathways. One of these switches may reside in a perturbation of mitochondrial function. Thus, a decrease in mitochondrial transmem‐ brane potential, followed by mitochondrial uncoupling and generation of reactive oxygen species, precedes nuclear alterations. It appears that molecules that participate in apoptotic decisionmaking also exert functions that are vital for normal cell proliferation and intermediate metabolism.—Kroemer, G., Petit, P., Zamzami, N., Vayssière, J.‐L., Mignotte, B. The biochemistry of programmed cell death. FASEB J. 9, 1277‐1287 (1995)
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Cites
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Cited by
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
The Role of Mitochondria in Apoptosis
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The proto-oncogene Bcl-2 and its role in regulating apoptosis
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Metadata
- Authors
- Kroemer, G., Petit, P., Zamzami, N., Vayssière, J., & Mignotte, B.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1995-10
- Volume
- 9
- Issue
- 13
- Pages
- 1277-1287
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1595972372
- Cited by
- 990
- References
- 74
- FWCI
- 29.96
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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