The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Molecular mechanisms and therapeutic strategies related to nitric oxide
Abstract
The formation of nitric oxide (NO) from L‐arginine is now recognized as a ubiquitous biochemical pathway involved in the regulation of the cardiovascular, central, and peripheral nervous systems, as well as in other homeostatic mechanisms. The L‐arginine:NO pathway comprises a substrate, L‐arginine, a family of enzymes, the NO synthases, and at least one physiological effector system, the soluble guanylate cyclase. NO also inhibits enzymes in target cells and can interact with oxygen‐derived radicals to produce other toxic substances. Thus, NO also plays a role in immunological host defense and in the pathophysiology of certain clinical conditions. Several steps in the L‐arginine:NO pathway are ame‐nable to manipulation. Some substances will change the concentration and/or actions of NO with conse‐quences that, in certain cases, may be therapeutic. In addition, other agents themselves generate NO and thus mimic the actions of the endogenous mediator. This brief overview will discuss some possible interventions in the pathway and the potential benefits as well as undesirable side effects that might arise from them.—Moncada, S., Higgs, E. A. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J. 9, 1319‐1330 (1995)
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Cites
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Self-citationNitric oxide synthases in mammals
Knowles, R. G., & Moncada, S. (1994) · Biochemical Journal · doi:10.1042/bj2980249 · Cited by 2,752
Self-citationEndogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans
Gustafsson, L. E., Leone, A. M., Persson, M. G., Wiklund, N. P., & Moncada, S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91268-h · Cited by 964
Self-citationHibbs, J. B., Westenfelder, C., Taintor, R., Vavrin, Z., Kablitz, C., Baranowski, R. L., Ward, J. H., Menlove, R. L., McMurry, M. P., & Kushner, J. P. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115666 · Cited by 485
Cited by
The Chemistry behind Antioxidant Capacity Assays
Huang, D., Ou, B., & Prior, R. L. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030723c · Cited by 6,162
Arginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Mammalian nitric oxide synthases
Stuehr, D. J. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00016-x · Cited by 996
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585
In Posidonia oceanica cadmium induces changes in DNA methylation and chromatin patterning
Greco, M., Chiappetta, A., Bruno, L., & Bitonti, M. B. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/err313 · Cited by 538
Metadata
- Authors
- Moncada, S., & Higgs, E. A.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1995-10
- Volume
- 9
- Issue
- 13
- Pages
- 1319-1330
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1883906051
- Cited by
- 776
- References
- 4
- FWCI
- 35.05
- Type
- journal article
- Language
- en
- Open access
- closed
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