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Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women.
Abstract
Regional fat distribution is an important determinant of insulin resistance in obesity. In the current study, the relationship between skeletal muscle insulin sensitivity, mid‐thigh muscle composition, and the metabolic profile of muscle was investigated. Muscle composition was assessed by computed tomography of the mid‐thigh, and by activities of marker enzymes of aerobic‐oxidative and glycolytic pathways and muscle fiber typing using biopsies of the vastus lateralis muscle. Muscle with reduced Hounsfield attenuation on computed tomography scans was increased in proportion to obesity, and was strongly related to insulin resistance, reduced muscle oxidative capacity, and increased anaerobic and glycolytic capacities by muscle. These findings suggest that as part of its expression of insulin resistance, skeletal muscle of obese individuals is also poorly equipped for substrate oxidation and manifests increased storage of fat.—Simoneau, J.‐A., Colberg, S. R., Thaete, F. L., Kelley, D. E. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J. 9, 273–278 (1995)
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From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [107]
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Metadata
- Authors
- Simoneau, J., Colberg, S. R., Thaete, F. L., & Kelley, D. E.
- Affiliations
- University of Pittsburgh (US)
- Veterans Health Administration (US)
- Corresponding author
- Kelley, David E.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1995-02
- Volume
- 9
- Issue
- 2
- Pages
- 273-278
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1592900851
- Cited by
- 362
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 12 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 15 · 2016: 12 · 2015: 14 · 2014: 8 · 2013: 12 · 2012: 16
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p30dk046204-15)
- National Institute of Diabetes and Digestive and Kidney Diseases (1P30DK-46204)
- National Center for Research Resources (M01RR000056, 5 MO1 RR 00056)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- skeletal muscle insulin sensitivity, insulin resistance, obesity, muscle composition, muscle fiber typing, glycolytic enzymes, oxidative enzymes, muscle fat content, regional fat distribution, vastus lateralis, aerobic metabolism, anaerobic metabolism, women
- MeSH terms
- Adenosine Triphosphatases, Adipose Tissue, Adult, Aerobiosis, Blood Glucose, Citrate (si)-Synthase, Creatine Kinase, Electron Transport Complex IV, Female, Glucose, Glyceraldehyde-3-Phosphate Dehydrogenases, Phosphorylases, Glycolysis, Hexokinase, Humans, Infusions, Intravenous, Insulin, Obesity, Phosphofructokinase-1, Thinness, Tomography, X-Ray Computed, 3-Hydroxyacyl CoA Dehydrogenases, Glucose Clamp Technique, Body Mass Index, Muscle, Skeletal, Muscle Fibers, Skeletal
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