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Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women.
Abstract
Regional fat distribution is an important determinant of insulin resistance in obesity. In the current study, the relationship between skeletal muscle insulin sensitivity, mid‐thigh muscle composition, and the metabolic profile of muscle was investigated. Muscle composition was assessed by computed tomography of the mid‐thigh, and by activities of marker enzymes of aerobic‐oxidative and glycolytic pathways and muscle fiber typing using biopsies of the vastus lateralis muscle. Muscle with reduced Hounsfield attenuation on computed tomography scans was increased in proportion to obesity, and was strongly related to insulin resistance, reduced muscle oxidative capacity, and increased anaerobic and glycolytic capacities by muscle. These findings suggest that as part of its expression of insulin resistance, skeletal muscle of obese individuals is also poorly equipped for substrate oxidation and manifests increased storage of fat.—Simoneau, J.‐A., Colberg, S. R., Thaete, F. L., Kelley, D. E. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J. 9, 273–278 (1995)
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“Impaired flexibility also correlates with intramyocellular accumulation of lipids (107), and 24-h RQ can predict subsequent weight gain (110, 113).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [107]
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Menshikova, E. V., Ritov, V. B., Ferrell, R. E., Azuma, K., Goodpaster, B. H., & Kelley, D. E. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01228.2006 · Cited by 113
Self-citationMuscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy
Larson‐Meyer, D. E., Smith, S. R., Heilbronn, L. K., Kelley, D. E., Ravussin, E., Newcomer, B. R., & The Look AHEAD Adipose Research Group (2006) · Obesity · doi:10.1038/oby.2006.10 · Cited by 111
“Generally, research studies using CT have followed the lead of Kelley’s group (17,18) and assessed the attenuation value of the midthigh region (36,37,42,43), whereas MRS studies have assessed lipid storage primarily in the soleus and TA muscles of the calf (10–14,44).”
BackgroundMethodInfluentialSelf-citationFatty acid metabolism in obesity and type 2 diabetes mellitus
Blaak, E. E. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2003290 · Cited by 110
“An inverse relationship between percentage body fat and the percentage of slow-twitch fibres has been found (Wade et al. 1990; Helge et al. 1999), although data are not consistent (Simoneau et al. 1995; Kempen et al. 1998).”
BackgroundExercise: it's the real thing!
Hawley, J. A., & Holloszy, J. O. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00185.x · Cited by 112
Ørtenblad, N., Mogensen, M., Petersen, I., Højlund, K., Levin, K., Sahlin, K., Beck-Nielsen, H., & Gaster, M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.04.001 · Cited by 101
“Several studies have shown an association between obesity, insulin resistance and reduced oxidative capacity in skeletal muscle [1,18,19], as demonstrated by the finding of decreased mitochondrial number, altered mitochondrial morphology and decreased levels of mitochondrial enzymes, i.”
BackgroundCalcineurin Inhibition and New-Onset Diabetes Mellitus After Transplantation
Chakkera, H. A., & Mandarino, L. J. (2012) · Transplantation · doi:10.1097/tp.0b013e31826e592e · Cited by 109
Lactate, a Neglected Factor for Diabetes and Cancer Interaction
Wu, Y., Dong, Y., Atefi, M. S., Liu, Y., Elshimali, Y., & Vadgama, J. V. (2016) · Mediators of Inflammation · doi:10.1155/2016/6456018 · Cited by 107
“Thus, patients with insulin resistance/diabetes exhibit augmented activity of glycolysis [31, 48].”
BackgroundLustgarten, M. S., & Fielding, R. A. (2011) · The journal of nutrition health & aging · doi:10.1007/s12603-011-0049-x · Cited by 104
“CT has been shown to be able to identify fat infiltration into skeletal muscle in young obese women (78).”
BackgroundImaging methods for analyzing body composition in human obesity and cardiometabolic disease
Seabolt, L., Welch, E., & Silver, H. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12842 · Cited by 87
Kelley, D. E., Williams, K. V., Price, J. C., McKolanis, T. M., Goodpaster, B. H., & Thaete, F. L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8027 · Cited by 103
“Subjects also had cross-sectional CT of the midthigh to determine AT distribution at this location and crosssectional area and the attenuation values of skeletal muscle, as previously described (21).”
Self-citationKitajima, Y., Eguchi, Y., Ishibashi, E., Nakashita, S., Aoki, S., Toda, S., Mizuta, T., Ozaki, I., Ono, N., Eguchi, T., et al. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0147-2 · Cited by 99
“The MM/F ratio accurately reflected muscular tissue steatosis with fat infiltration, because the CT number was affected by Kv (p), mA and the device [8, 9, 11, 16, 18, 19].”
BackgroundImbeault, P., Tremblay, A., Simoneau, J., & Joanisse, D. R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00394.2001 · Cited by 99
“OBESITY IS COMMONLY ASSOCIATED with an increase in skeletal muscle triglyceride deposition (9, 14), a feature associated with insulin resistance (12, 18, 24).”
BackgroundSelf-citationEffects of Exercise Training on Abdominal Obesity and Related Metabolic Complications
Buemann, B., & Tremblay, A. (1996) · Sports Medicine · doi:10.2165/00007256-199621030-00004 · Cited by 98
Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule
Elhassan, Y., Philp, A., & Lavery, G. G. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00092 · Cited by 93
“Supporting this, obesity reduces mitochondrial enzymatic activities [135, 136] and engenders metabolic inflexibility [137]; the inability to limit fatty oxidation and switch to carbohydrate oxidation in response to diet (and therefore insulin stimulation) [138–141].”
BackgroundTime‐course changes of muscle protein synthesis associated with obesity‐induced lipotoxicity
Masgrau, A., Mishellany‐Dutour, A., Murakami, H., Beaufrére, A. M., Walrand, S., Giraudet, C., Migné, C., Gerbaix, M., Metz, L., Courteix, D., et al. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.238576 · Cited by 100
“…alterations such as changes in fibre types (Lillioja et al. 1987; Tanner et al. 2002; Kemp et al. 2009) and in contractile and metabolic functions (Simoneau et al. 1995) have also been described in obesity, suggesting that not only muscle mass but also muscle quality may be impaired in obese…”
BackgroundBrochu, M., Mathieu, M.-E., Karelis, A. D., Doucet, É., Lavoie, M.-È., Garrel, D. R., & RABASA-LHORET, R. P. R. (2008) · Obesity · doi:10.1038/oby.2008.23 · Cited by 93
“Mid-thigh cross-sectional skeletal muscle and fat areas as well as muscle attenuation (MA) were measured (34).”
MethodCastellani, L. W., Goto, A. M., & Lusis, A. J. (2001) · Diabetes · doi:10.2337/diabetes.50.3.643 · Cited by 95
“Data from both animal and human studies have demonstrated that the accumulation of triglyceride within skeletal muscle is associated with skeletal muscle insulin resistance (39,40).”
Backgroundβ1- andβ2-Adrenoceptor-Mediated Thermogenesis and Lipid Utilization in Obese and Lean Men1
Schiffelers, S. L. H., Saris, W. H. M., Boomsma, F., & van Baak, M. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7506 · Cited by 85
“and have increased glycolytic and anaerobic capacities, as measured by the activities of several key enzymes in skeletal muscle biopsies (37, 38).”
BackgroundColberg, S. R., Hagberg, J. M., McCole, S. D., Zmuda, J. M., Thompson, P. D., & Kelley, D. E. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.5.2027 · Cited by 85
“Factors limiting fat oxidation during exercise in sedentary individuals may include lower oxidative capacity of skeletal muscle (28) and reduced skeletal muscle capillary density.”
BackgroundSelf-citationThe mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes
Walder, K., Kerr-Bayles, L., Civitarese, A., Jowett, J., Curran, J., Elliott, K., Trevaskis, J., Bishara, N., Zimmet, P., Mandarino, L., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1675-9 · Cited by 85
“Numerous studies have demonstrated defects in oxidative pathways in skeletal muscle of subjects with obesity and/or type 2 diabetes [3, 4, 7, 10, 11, 13], and it has been proposed that”
BackgroundSkeletal muscle mitochondrial capacity and insulin resistance in type 2 diabetes.
Bajpeyi, S., Pasarica, M., Moro, C., Conley, K., Jubrias, S., Sereda, O., Burk, D. H., Zhang, Z., Gupta, A., Kjems, L., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1621 · Cited by 84
Skeletal muscle triglycerides: an aspect of regional adiposity and insulin resistance.
Kelley, D. E. (2002) · PubMed · Cited by 84
Self-citationRole of muscle in triglyceride metabolism
Goodpaster, B. H., & Kelley, D. E. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199806000-00008 · Cited by 84
Self-citationSavage, P. D., Brochu, M., Poehlman, É. T., & Ades, P. A. (2003) · American Heart Journal · doi:10.1016/s0002-8703(02)94706-x · Cited by 82
Effect of weight loss on muscle lipid content in morbidly obese subjects
Gray, R. E., Tanner, C. J., Pories, W. J., MacDonald, K. G., & Houmard, J. A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00371.2002 · Cited by 81
“A negative relationship between insulin action and IMCL content has been reported (5, 7, 11, 17, 23, 25, 31, 33).”
BackgroundInteraction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM
Mandarino, L. J., Consoli, A., Jain, A., & Kelley, D. E. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.3.e463 · Cited by 82
Self-citationLane, R. H., Chandorkar, A. K., Flozak, A. S., & Simmons, R. A. (1998) · Pediatric Research · doi:10.1203/00006450-199805000-00001 · Cited by 81
Maddocks, M. M., Shrikrishna, D., Vitoriano, S., Natanek, S. A., Tanner, R., Hart, N., Kemp, P. R., Moxham, J., Polkey, M. I., & Hopkinson, N. S. (2014) · European Respiratory Journal · doi:10.1183/09031936.00066414 · Cited by 81
Calcaterra, V., Regalbuto, C., Porri, D., Pelizzo, G., Mazzon, E., Vinci, F., Zuccotti, G., Fabiano, V., & Cena, H. (2020) · Biomolecules · doi:10.3390/biom10091324 · Cited by 84
Fat and Carbohydrate Metabolism during Submaximal Exercise in Children
Aucouturier, J., Baker, J. S., & Duché, P. (2008) · Sports Medicine · doi:10.2165/00007256-200838030-00003 · Cited by 77
Impaired skeletal muscle perfusion in obese Zucker rats
Frisbee, J. C. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00239.2003 · Cited by 79
“(37) demonstrated a reduced oxidative capacity of skeletal muscle of obese, diabetic women, with a shift in metabolic capacity toward anaerobic and glycolytic sources of energy.”
BackgroundMalenfant, P., Tremblay, A., Doucet, É., Imbeault, P., Simoneau, J., & Joanisse, D. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.4.e632 · Cited by 78
Self-citationSkeletal Muscle Metabolic Dysfunction in Obesity and Metabolic Syndrome
Wells, G. D., Noseworthy, M. D., Hamilton, J. K., Tarnopolski, M., & Tein, I. (2008) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100007538 · Cited by 79
Racial Differences in Insulin Resistance and Mid‐Thigh Fat Deposition in Postmenopausal Women
Ryan, A. S., Nicklas, B. J., & Berman, D. M. (2002) · Obesity Research · doi:10.1038/oby.2002.47 · Cited by 79
Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus
Azuma, K., Heilbronn, L. K., Albu, J., Smith, S. R., Ravussin, É., & Kelley, D. E. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00394.2006 · Cited by 80
“Skeletal muscle lipid content is increased in obesity and in T2DM, as has been shown using tissue biopsy studies (18, 30), imaging with magnetic resonance spectroscopy (32), and by comparison of CT attenuation values, as our group reported a number of years ago (22, 26, 40).”
BackgroundSelf-citationEffects of testosterone and exercise on muscle leanness in eugonadal men with AIDS wasting
Fairfield, W. P., Treat, M. D., Rosenthal, D. I., Frontera, W. R., Stanley, T. L., Corcoran, C. P., Costello, M., Parlman, K., Schoenfeld, D., Klibanski, A., et al. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2166 · Cited by 76
“For example, in a different population of HIV-infected patients with the lipodystrophy syndrome, changes in intramuscular fat content (as assessed by attenuation value) may correlate with changes in insulin sensitivity, as has previously been shown in normal and obese subjects (10, 24).”
ResultKetone body metabolism in lean and obese women
Vice, E., Privette, J., Hickner, R. C., & Barakat, H. A. (2005) · Metabolism · doi:10.1016/j.metabol.2005.05.023 · Cited by 75
Robinson, F. P., Quinn, L. T., & Rimmer, J. H. (2006) · Biological Research For Nursing · doi:10.1177/1099800406295520 · Cited by 74
Secondary muscle pathology and metabolic dysregulation in adults with cerebral palsy
Peterson, M. D., Gordon, P. M., Hurvitz, E. A., & Burant, C. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00338.2012 · Cited by 74
Metabolic consequences of weight loss on glucose metabolism and insulin action in type 2 diabetes
Williams, K. V., & Kelley, D. E. (2000) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2000.00049.x · Cited by 72
Self-citationGlucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis
Meng, Z., Gong, J., Chen, Z., Sun, J., Xiao, Y., Wang, L., Li, Y., Liu, J., Xu, X., & Lin, J. D. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.007 · Cited by 69
“, 2010), and a shift from oxidative to glycolytic muscle fiber type in patients with type 2 diabetes (Lillioja et al., 1987; Simoneau et al., 1995; Simoneau and Kelley, 1997).”
BackgroundPerseghin, G., Scifo, P., Danna, M., Battezzati, A., Benedini, S., Meneghini, E., Maschio, A. D., & Luzi, L. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00127.2002 · Cited by 69
“In our study lipid oxidation was assessed using indirect calorimetry, but this method is not a direct measure of leg lipid oxidation (24, 25) or of the metabolic oxidative capacity of the muscle (17, 24, 48); therefore, these data must be taken with caution.”
BackgroundMethodInsulin resistance and associated metabolic abnormalities in muscle: effects of exercise
Pérez‐Martin, A., de Mauverger, É. R., & Mercier, J. G. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00024.x · Cited by 70
Brochu, M., Tchernof, A., Turner, A. N., Ades, P. A., & Poehlman, É. T. (2003) · Metabolism · doi:10.1053/meta.2003.50095 · Cited by 69
Long Non-Coding RNAs in Metabolic Organs and Energy Homeostasis
Giroud, M., & Scheideler, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122578 · Cited by 69
“Upon obesity, reduced muscular oxidative capacity as well as elevated production of reactive oxygen species (ROS) in mitochondria has been correlated with the development of insulin resistance [74,75].”
BackgroundHoffman, D. J., Martins, P., Roberts, S. B., & Sawaya, A. L. (2007) · Nutrition · doi:10.1016/j.nut.2007.06.006 · Cited by 68
Berhane, F., Fite, A., Daboul, N., Al-Janabi, W., Msallaty, Z., Caruso, M. A., Lewis, M. K., Yi, Z., Diamond, M. P., Abou‐Samra, A., et al. (2015) · Journal of Diabetes Research · doi:10.1155/2015/102054 · Cited by 70
Liu, L., Shi, X., Choi, C. S., Shulman, G. I., Klaus, K., Nair, K. S., Schwartz, G. J., Zhang, Y., Goldberg, I. J., & Yu, Y.-H. (2009) · Diabetes · doi:10.2337/db08-1096 · Cited by 66
“In human skeletal muscle, insulin-stimulated glucose transport directly correlates with the percentage of oxidative type I myofibers (4-6).”
BackgroundEffect of Training on Muscle Triacylglycerol and Structural Lipids
Helge, J. W., & Dela, F. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1881 · Cited by 66
“This is an explanation that intrinsically gains strength from the fact that obese and diabetic subjects overall have a relatively smaller mitochondrial capacity (39,40) and higher muscle triacylglycerol stores (31,40,41) and thus less storage capacity around the mitochondria.”
BackgroundPeripheral Effect of α-Melanocyte-stimulating Hormone on Fatty Acid Oxidation in Skeletal Muscle
An, J. J., Rhee, Y., Kim, S. H., Kim, D. M., Han, D., Hwang, J. H., Jin, Y.-J., Soo, B., Baik, J., Lee, W. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603454200 · Cited by 66
AMPK activators – potential therapeutics for metabolic and other diseases
Zhou, G., Sebhat, I. K., & Zhang, B. B. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01967.x · Cited by 63
“In a state of insulin resistance, glucose uptake and utilization are dramatically decreased (Simoneau et al. 1995) and skeletal muscle becomes metabolically inflexible, unable to switch between glucose and fatty acid use (Kelley et al.”
BackgroundKelley, D. E. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04271.x · Cited by 98
Self-citationDriscoll, S. D., Meininger, G. E., Ljungquist, K. L., Hadigan, C. M., Torriani, M., Klibanski, A., Frontera, W. R., & Grinspoon, S. K. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031858 · Cited by 61
The lifecycle of skeletal muscle mitochondria in obesity
Pileggi, C. A., Parmar, G., & Harper, M. (2021) · Obesity Reviews · doi:10.1111/obr.13164 · Cited by 61
“These hormonal axes are often dysregulated with obesity and disrupt satiety.6 Moreover, adipocyte hydrolysis of triglycerides promotes lipid accretion in nonadipose tissues including the liver and skeletal muscle.4 Research on the role of skeletal muscle in obesity has largely focussed on the development of insulin re…”
BackgroundInfluentialDietary restriction and walking reduce fat deposition in the midthigh in obese older women
Ryan, A. S., Nicklas, B. J., Berman, D. M., & Dennis, K. E. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.708 · Cited by 61
Park, S. Y., Choi, G. H., Choi, H. I., Ryu, J., Jung, C. Y., & Lee, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409399200 · Cited by 61
Mizuno, T., Matsui, Y., Tomida, M., Suzuki, Y., Nishita, Y., Tange, C., Shimokata, H., Imagama, S., Otsuka, R., & Arai, H. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12715 · Cited by 60
“Increases in adipose tissue can be caused by oestrogen and androgen deficiencies, unloading, exposure to glucocorticoids, and reduced capacity for lipid oxidation.(28,31) The volumes of intramuscular and intermuscular adipose tissues in the thighs have been reported to increase with age.”
BackgroundJuraschek, S. P., Selvin, E., Miller, E. R., Brancati, F. L., & Young, J. H. (2013) · Annals of Epidemiology · doi:10.1016/j.annepidem.2013.09.005 · Cited by 61
Effects of weight loss and leptin on skeletal muscle in human subjects
Baldwin, K. M., Joanisse, D. R., Haddad, F., Goldsmith, R. L., Gallagher, D., Pavlovich, K. H., Shamoon, E. L., Leibel, R. L., & Rosenbaum, M. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00397.2011 · Cited by 58
Insulin regulation of mitochondrial proteins and oxidative phosphorylation in human muscle
Boirie, Y. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.09.002 · Cited by 57
Carey, D. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199802000-00008 · Cited by 56
Shantha, G. P. S., Wasserman, B. A., Astor, B. C., Coresh, J., Brancati, F., Sharrett, A. R., & Young, J. H. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.02.014 · Cited by 56
“This evidence includes the association of insulin resistance and type 2 diabetes with maternally inherited forms of diabetes [2, 3], increased glycolysis in muscle [4, 30, 31] decreased mitochondrial size and density [32, 33], decreased oxidative gene expression [34, 35] decreased oxidative phosphorylation and decreas…”
Simoneau, J., Kelley, D. E., Neverova, M., & Warden, C. H. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.15.1739 · Cited by 57
“COX activity was assayed spectrophotometrically according to a method previously used (28) and its activity was expressed in units of micromoles of substrate per minute, per gram of wet weight tissue (U/g).”
MethodSelf-citationIda, S., Nakai, M., Ito, S., Ishihara, Y., Imataka, K., Uchida, A., Monguchi, K., Kaneko, R., Fujiwara, R., Takahashi, H., et al. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.06.012 · Cited by 55
Keildson, S., Fadista, J., Ladenvall, C., Hedman, Å. K., Elgzyri, T., Small, K. S., Grundberg, E., Nica, A. C., Glass, D., Richards, J. B., et al. (2013) · Diabetes · doi:10.2337/db13-1301 · Cited by 55
“However, increased PFKM activity has been associated with increased deposition of muscle fat as measured by computed tomography (49), and increased glycolytic capacity in T2D has been suggested (49–54).”
BackgroundBhullar, A. S., Anoveros‐Barrera, A., Dunichand‐Hoedl, A. R., Martins, K. J. B., Bigam, D. L., Khadaroo, R. G., McMullen, T. P. W., Bathe, O. F., Putman, C. T., Clandinin, M. T., et al. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12533 · Cited by 57
Katoh, S., Hata, S., Matsushima, M., Ikemoto, S., Inoue, Y., Yokoyama, J., & Tajima, N. (2001) · Metabolism · doi:10.1053/meta.2001.21691 · Cited by 54
Blood Glucose Regulation during Prolonged, Submaximal, Continuous Exercise: A Guide for Clinicians
Goodwin, M. L. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400325 · Cited by 53
Newcomer, B. R., Larson‐Meyer, D. E., Hunter, G., & Weinsier, R. L. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801673 · Cited by 52
Bertoldo, A., Pencek, R. R., Azuma, K., Price, J. C., Kelley, C., Cobelli, C., & Kelley, D. E. (2006) · Diabetes · doi:10.2337/db06-0762 · Cited by 52
“Human skeletal muscles are, however, generally of mixed fiber type, though ex vivo determinations of oxidative capacity contributes to gradations of insulin sensitivity or resistance (44).”
BackgroundSelf-citationDiet, energy metabolism and mitochondrial biogenesis
Civitarese, A. E., Smith, S. R., & Ravussin, É. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f0ecd2 · Cited by 52
Ida, S., Kaneko, R., Imataka, K., & Murata, K. (2019) · Journal of Diabetes Research · doi:10.1155/2019/1365189 · Cited by 50
“This suggests that chronic inflammation, oxidative stress, and insulin resistance play a role in the onset of sarcopenia [8, 9].”
BackgroundHan, D.-H., Nolte, L. A., Ju, J.-S., Coleman, T., Holloszy, J. O., & Semenkovich, C. F. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00434.2003 · Cited by 49
“Mitochondrial enzymes tend to be decreased in insulin-resistant states (4, 43, 44), and skeletal muscle oxidative capacity is directly correlated with insulin sensitivity (23, 38, 39).”
BackgroundBöhm, A., Keuper, M., Meile, T., Zdichavsky, M., Fritsche, A., Häring, H., de Angelis, M. H., Staiger, H., & Frankó, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-69016-9 · Cited by 48
Sarcopenic obesity: What about in the cancer setting?
Cappellari, G. G., Brasacchio, C., Laudisio, D., Lubrano, C., Pivari, F., Barrea, L., Muscogiuri, G., Savastano, S., & Colao, A. (2022) · Nutrition · doi:10.1016/j.nut.2022.111624 · Cited by 49
Samjoo, I. A., Safdar, A., Hamadeh, M. J., Glover, A. W., Mocellin, N. J., Santana, J. O., Little, J. P., Steinberg, G. R., Raha, S., & Tarnopolsky, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066322 · Cited by 56
“resistance in obesity remains elusive, defects in skeletal muscle mitochondrial function [2,3,4,5,6,7,8] including aberrant mito-”
BackgroundDeBrosse, C., Nanga, R. P. R., Wilson, N. E., D’Aquilla, K., Elliott, M. A., Hariharan, H., Yan, F., Wade, K., Nguyen, S., Worsley, D., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88207 · Cited by 49
“Differences in muscle fiber type may contribute to metabolic disease; there is some evidence that the ratio of glycolytic/oxidative enzyme activities is related to insulin resistance in obese patients and some diabetic populations (18, 19).”
BackgroundTurner, N. C., & Clapham, J. C. (1998) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8845-5_2 · Cited by 46
Molecular and biochemical regulation of skeletal muscle metabolism
Zumbaugh, M. D., Johnson, S., Shi, T. H., & Gerrard, D. E. (2022) · Journal of Animal Science · doi:10.1093/jas/skac035 · Cited by 56
Association of Lactate With Blood Pressure Before and After Rapid Weight Loss
Crawford, S., Ambrose, M. S., Hoogeveen, R. C., Brancati, F. L., Ballantyne, C. M., & Young, J. H. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.282 · Cited by 46
Association between sarcopenia and sleep disorder in older patients with diabetes
Ida, S., Kaneko, R., Nagata, H., Noguchi, Y., Araki, Y., Nakai, M., Ito, S., Ishihara, Y., Imataka, K., & Murata, K. (2019) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13627 · Cited by 48
Fernyhough, P., & McGavock, J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00027-8 · Cited by 50
Dériaz, O., Dumont, M., Bergeron, N., Després, J.-P., Brochu, M., & Prud'homme, D. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801809 · Cited by 45
Obesity, free fatty acids, and insulin resistance
Boden, G. H. (2001) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200110000-00002 · Cited by 44
Skeletal Muscle Weakness is Related to Insulin Resistance in Patients with Chronic Heart Failure
Doehner, W., Turhan, G., Leyva, F., Rauchhaus, M., Sandek, A., Jankowska, E. A., von Haehling, S., & Anker, S. D. (2015) · ESC Heart Failure · doi:10.1002/ehf2.12035 · Cited by 46
“Secondly, insulin resistance is associated with disturbances in skeletal muscle glycolytic and oxidative enzyme activity, as shown in the context of obesity(9) and in non-insulin-dependent diabetes mellitus (NIDDM).(10) NIDDM appears to involve an imbalance between nonoxidative glycolysis and oxidative glycolysis.”
BackgroundPark, M. J., Cho, J. M., Jeon, K. N., Bae, K. S., Kim, H. C., Choi, D. S., Na, J. B., Choi, H. C., Choi, H. Y., Kim, J. E., et al. (2014) · Academic Radiology · doi:10.1016/j.acra.2014.02.003 · Cited by 43
Skeletal muscle lipid metabolism: A frontier for new insights into fuel homeostasis
Cortright, R. N., Muoio, D. M., & Dohm, G. L. (1997) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(97)89660-x · Cited by 44
Jeong, H.-J., Park, S., Yang, W., & Lee, W. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.104 · Cited by 43
“Cellular oxidative capacity, which depends mostly on mitochondrial function, is related directly to insulin sensitivity in skeletal muscles [7,8], and reduced mitochondria activity has been observed in patients with obesity and type 2 diabetes [9,10].”
BackgroundJana, B. A., Chintamaneni, P. K., Krishnamurthy, P. T., Wadhwani, A., & Mohankumar, S. K. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4551-7 · Cited by 45
Schiffelers, S. L. H., Saris, W. H. M., & van Baak, M. A. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801528 · Cited by 45
Unreliable use of standard muscle hydration value in obesity
Mingrone, G., BERTUZZI, A., Capristo, E., Greco, A., Manco, M., Pietrobelli, A., Salinari, S., & Heymsfield, S. B. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e365 · Cited by 43
“(20) reported similar findings in obese men, and these data were later confirmed in women (35).”
ResultPeterson, M. D., Liu, D., Gordish-Dressman, H., Hubal, M. J., Pistilli, E., Angelopoulos, T. J., Clarkson, P. M., Moyna, N. M., Pescatello, L. S., Seip, R. L., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.257 · Cited by 39
O’Brien, L. C., Wade, R. C., Segal, L., Chen, Q., Savas, J. F., Lesnefsky, E. J., & Gorgey, A. S. (2017) · Physiological Reports · doi:10.14814/phy2.13080 · Cited by 38
“This is in agreement with studies that found that IMF was negatively related to CS (Bharadwaj et al. 2015; Simoneau et al. 1995).”
ResultGaster, M., & Beck-Nielsen, H. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.05.006 · Cited by 38
“Several studies have described a reduced expression of oxidative enzymes and activity [13–15] and, recently, Kelly et al.”
BackgroundNew insights on how and where to measure muscle mass
Fayh, A. P. T., de Sousa, I. M., & González, M. C. (2020) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000524 · Cited by 38
Diabetic and Metabolic Programming: Mechanisms Altering the Intrauterine Milieu
Eberle, C., & Ament, C. (2012) · ISRN Pediatrics · doi:10.5402/2012/975685 · Cited by 38
Zaborska, K. E., Dadi, P. K., Dickerson, M. T., Nakhe, A. Y., Thorson, A. S., Schaub, C. M., Graff, S. M., Stanley, J. E., Kondapavuluru, R. S., Denton, J. S., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101056 · Cited by 33
Reduced Respiratory Capacity in Muscle Mitochondria of Obese Subjects
Bakkman, L., Fernström, M., Loogna, P., Rooyackers, O., Brandt, L., & Lagerros, Y. T. (2010) · Obesity Facts · doi:10.1159/000320167 · Cited by 34
Dubé, M., Lemieux, S., Piché, M., Corneau, L., Bergeron, J., Riou, M.-È., & Weisnagel, S. J. (2011) · Obesity · doi:10.1038/oby.2010.348 · Cited by 36
“A possible link between LAMS and VAT appears to be insulin resistance.”
BackgroundInfluentialCreatine kinase activity and blood pressure in a normal population: the Tromsø study
Johnsen, S. H., Lilleng, H., Wilsgaard, T., & Bekkelund, S. I. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834068e0 · Cited by 36
Metadata
- Authors
- Simoneau, J., Colberg, S. R., Thaete, F. L., & Kelley, D. E.
- Affiliations
- University of Pittsburgh (US)
- Veterans Health Administration (US)
- Corresponding author
- Kelley, David E.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1995-02
- Volume
- 9
- Issue
- 2
- Pages
- 273-278
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1592900851
- Cited by
- 362
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 12 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 15 · 2016: 12 · 2015: 14 · 2014: 8 · 2013: 12 · 2012: 16
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p30dk046204-15)
- National Institute of Diabetes and Digestive and Kidney Diseases (1P30DK-46204)
- National Center for Research Resources (M01RR000056, 5 MO1 RR 00056)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- skeletal muscle insulin sensitivity, insulin resistance, obesity, muscle composition, muscle fiber typing, glycolytic enzymes, oxidative enzymes, muscle fat content, regional fat distribution, vastus lateralis, aerobic metabolism, anaerobic metabolism, women
- MeSH terms
- Adenosine Triphosphatases, Adipose Tissue, Adult, Aerobiosis, Blood Glucose, Citrate (si)-Synthase, Creatine Kinase, Electron Transport Complex IV, Female, Glucose, Glyceraldehyde-3-Phosphate Dehydrogenases, Phosphorylases, Glycolysis, Hexokinase, Humans, Infusions, Intravenous, Insulin, Obesity, Phosphofructokinase-1, Thinness, Tomography, X-Ray Computed, 3-Hydroxyacyl CoA Dehydrogenases, Glucose Clamp Technique, Body Mass Index, Muscle, Skeletal, Muscle Fibers, Skeletal
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