The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Anti‐inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL‐12 and up‐regulation of IL‐10 production
Abstract
Cytokines are critical in regulating unresponsiveness versus immunity towards enteric antigens derived from the intestinal flora and ingested food. There is increasing evidence that butyrate, a major metabolite of intestinal bacteria and crucial energy source for gut epithelial cells, also possesses anti‐inflammatory properties. Its influence on cytokine production, however, is not established. Here, we report that butyrate strongly inhibits interleukin‐12 (IL‐12) production by suppression of both IL‐12p35 and IL‐12p40 mRNA accumulation, but massively enhances IL‐10 secretion in Staphylococcus aureus cell‐stimulated human monocytes. The effect of butyrate on IL‐12 production was irreversible upon the addition of neutralizing antibodies to IL‐10 or transforming growth factor β 1 and of indomethacin. In anti‐CD3‐stimulated peripheral blood mononuclear cells, butyrate enhanced IL‐10 and IL‐4 secretion but reduced the release of IL‐2 and interferon‐γ. The latter effect was in part a result of suppressed IL‐12 production but also a result of inhibition of IL‐12 receptor expression on T cells. These data demonstrate a novel anti‐inflammatory property of butyrate that may have broad implications for the regulation of immune responses in vivo and could be exploited as new therapeutic approach in inflammatory conditions.
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Morgan, X. C., Tickle, T. L., Sokol, H., Gevers, D., Devaney, K. L., Ward, D. V., Reyes, J. A., Shah, S. A., LeLeiko, N., Snapper, S. B., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-9-r79 · Cited by 2,713
The role of short chain fatty acids in health and disease
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425
The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?
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Regulation of inflammation by short chain fatty acids
Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
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Metadata
- Authors
- Säemann, M. D., Böhmig, G. A., Österreicher, C. H., Burtscher, H., Parolini, O., Diakos, C., Stöckl, J., Hörl, W. H., & Zlabinger, G. J.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2000-10-06
- Volume
- 14
- Issue
- 15
- Pages
- 2380-2382
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2161667744
- Cited by
- 482
- References
- 55
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Säemann, M. D., Böhmig, G. A., Österreicher, C. H., Burtscher, H., Parolini, O., Diakos, C., Stöckl, J., Hörl, W. H., & Zlabinger, G. J. (2000). Anti‐inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL‐12 and up‐regulation of IL‐10 production. The FASEB Journal. https://doi.org/10.1096/fj.00-0359fje
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
