The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Nitrosation and oxidation in the regulation of gene expression
Abstract
A growing body of evidence suggests that the cellular response to oxidative and nitrosative stress is primarily regulated at the level of transcription. Posttranslational modification of transcription factors may provide a mechanism by which cells sense these redox changes. In bacteria, for example, OxyR senses redox‐related changes via oxidation or nitrosylation of a free thiol in the DNA binding region. This mode of regulation may serve as a paradigm for redox‐sensing by eukaryotic transcription factors as most—including NF‐KB, AP‐1, and p53—contain reactive thiols in their DNA binding regions, the modification of which alters binding in vitro . Several of these transcription factors have been found to be sensitive to both reactive oxygen species and nitric oxide‐related species in vivo . It remains entirely unclear, however, if oxidation or nitrosylation of eukaryotic transcription factors is an important mode of regulation, or whether transcriptional activating pathways are principally controlled at other redox‐sensitive levels.—Marshall, H. E., Merchant, K., Stamler, J. S. Nitrosation and oxidation in the regulation of gene expression. FASEB J. 14, 1889–1900 (2000)
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Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., & Stamler, J. S. (1993) · Nature · doi:10.1038/364626a0 · Cited by 2,433
Self-citationRole of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
Xie, Q. W., Kashiwabara, Y., & Nathan, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37600-7 · Cited by 2,212 · cited 1×
“NF-kB activation is essential for NOS2 gene transcription (49), and NO-related molecules modulate NF-kB signal transduction in a cell- and stimulus-specific manner.”
BackgroundRedox Regulation of Fos and Jun DNA-Binding Activity in Vitro
Abate, C., Patel, L., Rauscher, F. J., & Curran, T. (1990) · Science · doi:10.1126/science.2118682 · Cited by 1,573
Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.
Toledano, M. B., & Leonard, W. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4328 · Cited by 657
Arnelle, D. R., & Stamler, J. S. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1231 · Cited by 604 · cited 1×
“These data are, however, difficult to reconcile with the observation that a stable SNO can form in wild-type OxyR, because S-nitrosylation should have catalyzed disulfide formation with release of the NO group (14, 21); therefore, the data do not rule out the possibility of alternative mechanisms of activation in vivo.”
BackgroundSelf-citationNitrosative stress: Metabolic pathway involving the flavohemoglobin
Hausladen, A., Gow, A. J., & Stamler, J. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14100 · Cited by 285
Self-citationRole of cysteine62in DNA recognition by the P50 subunit of NF-xB
Matthews, J. R., Kaszubska, W., Turcatti, G., Wells, T. N. C., & Hay, R. T. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.8.1727 · Cited by 147
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Nitric oxide and the immune response
Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447
Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484
Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690
Glutathione in Cancer Biology and Therapy
Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898
Metadata
- Authors
- Marshall, H. E., Merchant, K., & Stamler, J. S.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2000-10
- Volume
- 14
- Issue
- 13
- Pages
- 1889-1900
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2023633834
- Cited by
- 424
- References
- 7
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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