The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Leptin regulation of the immune response and the immunodeficiency of malnutrition 1
Abstract
Leptin is a 16 kDa protein mainly produced by adipose tissue in proportion to adipose tissue mass. Originally thought to be a satiety factor, leptin is a pleiotropic molecule. In addition to playing a role in energy regulation, leptin also regulates endocrine and immune functions. Both the structure of leptin and that of its receptor suggest that leptin might be classified as a cytokine. The secondary structure of leptin has similarities to the long‐chain helical cytokines family, which includes interleukin 6 (IL‐6), IL‐11, CNTF, and LIF, and the leptin receptor is homologous to the gp‐130 signal‐transducing subunit of the IL‐6‐type cytokine receptors. Leptin plays a role in innate and acquired immunity. Leptin levels increase acutely during infection and inflammation, and may represent a protective component of the host response to inflammation. More important, leptin deficiency increases susceptibility to infectious and inflammatory stimuli and is associated with dysregulation of cytokine production. Leptin deficiency also causes a defect in hematopoiesis. Leptin regulates T cells responses, polarizing Th cells toward a Th1 phenotype. Low leptin levels occurring during starvation mediate the neuroendocrine and immune dysfunction of starvation.—Faggioni, R., Feingold, K. R., Grunfeld, C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J. 15, 2565–2571 (2001)
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Cited by
Adipokines as emerging mediators of immune response and inflammation
Lago, F., Dieguez, C., Gómez-Reino, J., & Gualillo, O. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0674 · Cited by 567
Uraemic sarcopenia: aetiology and implications
Fahal, I. H. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft070 · Cited by 357
Inflammatory Process in Type 2 Diabetes: The Role of Cytokines
ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.039 · Cited by 309
Dietary Factors Alter Hepatic Innate Immune System in Mice With Nonalcoholic Ratty Liver Disease * #
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Ilich, J. Z., Kelly, O. J., Inglis, J. E., Panton, L. B., Duque, G., & Ormsbee, M. J. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.02.007 · Cited by 282
Metadata
- Authors
- Faggioni, R., Feingold, K. R., & Grunfeld, C.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2001-12
- Volume
- 15
- Issue
- 14
- Pages
- 2565-2571
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2068186755
- Cited by
- 472
- References
- 11
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- closed
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