The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
MT1‐MMP expression promotes tumor growth and angiogenesis through an up‐regulation of vascular endothelial growth factor expression
Abstract
Membrane type 1 metalloprotease (MT1‐MMP) is a transmembrane metalloprotease that plays a major role in the extracellular matrix remodeling, directly by degrading several of its components and indirectly by activating pro‐MMP 2. We investigated the effects of MT1‐MMP overexpression on in vitro and in vivo properties of human breast adenocarcinoma MCF7 cells, which do not express MT1‐MMP or MMP‐2. MT1‐MMP and MMP‐2 cDNAs were either transfected alone or cotransfected. All clones overexpressing MT1‐MMP 1) were able to activate endogenous or exogenous pro‐MMP‐2, 2) displayed an enhanced in vitro invasiveness through matrigel‐coated filters independent of MMP‐2 transfection, 3) induced the rapid development of highly vascularized tumors when injected subcutanously in nude mice, and 4) promoted blood vessels sprouting in the rat aortic ring assay. These effects were observed in all clones overexpressing MT1‐MMP regardless of MMP‐2 expression levels, suggesting that the production of MMP‐2 by tumor cells themselves does not play a critical role in these events. The angiogenic phenotype of MT1‐MMP‐producing cells was associated with an up‐regulation of VEGF expression. These results emphasize the importance of MT1‐MMP during tumor angiogenesis and open new opportunities for the development of anti‐angiogenic strategies combining inhibitors of MT1‐MMP and VEGF antagonists.—Sounni, N. E., Devy, L., Hajitou, A., Frankenne, F., Munaut, C., Gilles, C., Deroanne, C., Thompson, E. W., Foidart, J. M., Noel, A. MT1‐MMP expression promotes tumor growth and angiogenesis through an up‐regulation of vascular en‐dothelial growth factor expression. FASEB J. 16, 555–564 (2002)
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Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers
Rempe, R. G., Hartz, A. M., & Bauer, B. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16655551 · Cited by 721
Use of the mouse aortic ring assay to study angiogenesis
Baker, M., Robinson, S. D., Lechertier, T., Barber, P. R., Tavora, B., D'Amico, G., Jones, D. T., Vojnovic, B., & Hodivala-Dilke, K. (2012) · Nature Protocols · doi:10.1038/nprot.2011.435 · Cited by 477
Deryugina, E. I., & Quigley, J. P. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.04.004 · Cited by 422
Membrane-type matrix metalloproteinases: Their functions and regulations
Itoh, Y. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.03.004 · Cited by 401
Lee, C., Kim, M.-J., Kumar, A., Lee, H.-W., Yang, Y., & Kim, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02249-0 · Cited by 365
Metadata
- Authors
- Sounni, N. E., Devy, L., Hajitou, A., Frankenne, F., Munaut, C., Gilles, C., Deroanne, C., Thompson, E. W., Foidart, J. M., & Noel, A.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2002-04
- Volume
- 16
- Issue
- 6
- Pages
- 555-564
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1979476810
- Cited by
- 260
- References
- 42
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sounni, N. E., Devy, L., Hajitou, A., Frankenne, F., Munaut, C., Gilles, C., Deroanne, C., Thompson, E. W., Foidart, J. M., & Noel, A. (2002). MT1‐MMP expression promotes tumor growth and angiogenesis through an up‐regulation of vascular endothelial growth factor expression. The FASEB Journal. https://doi.org/10.1096/fj.01-0790com
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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