The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Therapeutic lymphangiogenesis with human recombinant VEGF‐C
Abstract
Chronic regional impairments of the lymphatic circulation often lead to striking architectural abnormalities in the lymphedematous tissues. Lymphedema is a common, disabling disease that currently lacks a cure. Vascular endothelial growth factors C and D mediate lymphangiogenesis through the VEGFR‐3 receptor on lymphatic endothelia. The purpose of this study was to investigate the therapeutic potential for lymphangiogenesis with VEGF‐C. We developed a rabbit ear model to simulate human chronic postsurgical lymphatic insufficiency. Successful, sustained surgical ablation of the ear lymphatics was confirmed by water displacement volumetry. After complete healing, the experimental animals (n=8) received a single, s.c. 100 μg dose of VEGF‐C in the operated ear; controls (n=8) received normal saline. Radionuclide lymphoscintigraphy was performed to quantitate lymphatic function. Immunohistochemistry (IHC) was performed 7–8 days following treatment. After VEGF‐C, there was a quantifiable amelioration of lymphatic function. IHC confirmed a significant increase in lymphatic vascularity, along with reversal of the intense tissue hypercellularity of untreated lymphedema. This study confirms the capacity of a single dose of VEGF‐C to induce therapeutic lymphangiogenesis in acquired lymphedema. In addition to improving lymphatic function and vascularity, VEGF‐C can apparently reverse the abnormalities in tissue architecture that accompany chronic lymphatic insufficiency.
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Cites
Clinical applications of angiogenic growth factors and their inhibitors
Ferrara, N., & Alitalo, K. (1999) · Nature Medicine · doi:10.1038/70928 · Cited by 1,004
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Cited by
The lymphatic vasculature in disease
Alitalo, K. (2011) · Nature Medicine · doi:10.1038/nm.2545 · Cited by 962
Self-citationTumour vascularization: sprouting angiogenesis and beyond
Hillen, F., & Griffioen, A. W. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9094-7 · Cited by 583
Cardiac lymphatics are heterogeneous in origin and respond to injury
Klotz, L., Norman, S., Vieira, J. M., Masters, M., Rohling, M., Dubé, K. N., Bollini, S., Matsuzaki, F., Carr, C. A., & Riley, P. R. (2015) · Nature · doi:10.1038/nature14483 · Cited by 506
Lymphatic vasculature development
Oliver, G. (2004) · Nature Reviews Immunology · doi:10.1038/nri1258 · Cited by 461
Tammela, T., Saaristo, A., Holopainen, T., Lyytikkä, J., Kotronen, A., Pitkonen, M., Abo-Ramadan, U., Ylä-Herttuala, S., Petrova, T. V., & Alitalo, K. (2007) · Nature Medicine · doi:10.1038/nm1689 · Cited by 364
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Metadata
- Authors
- Szuba, A., Skobe, M., Karkkainen, M. J., Shin, W. S., Beynet, D. P., Rockson, N. B., Dakhil, N., Spilman, S., Goris, M. L., Strauss, H. W., Quertermous, T., Alitalo, K., & Rockson, S. G.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2002-10-18
- Volume
- 16
- Issue
- 14
- Pages
- 1985-1987
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2137100240
- Cited by
- 260
- References
- 1
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Szuba, A., Skobe, M., Karkkainen, M. J., Shin, W. S., Beynet, D. P., Rockson, N. B., Dakhil, N., Spilman, S., Goris, M. L., Strauss, H. W., Quertermous, T., Alitalo, K., & Rockson, S. G. (2002). Therapeutic lymphangiogenesis with human recombinant VEGF‐C. The FASEB Journal. https://doi.org/10.1096/fj.02-0401fje
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