Clinical applications of angiogenic growth factors and their inhibitors

Tumor angiogenesis: therapeutic implications

Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187 · see citing works

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725 · see citing works

Angiogenesis in cancer, vascular, rheumatoid and other disease

Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627 · see citing works

Mechanisms of angiogenesis

Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727 · see citing works

The Biology of Vascular Endothelial Growth Factor

Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,540 · see citing works

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,114 · see citing works

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

Aiello, L. P., Avery, R. L., Arrigg, P. G., Keyt, B. A., JAMPEL, H. D., Shah, S. T., Pasquale, L. R., Thieme, H., Iwamoto, M., Park, J. E., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199412013312203 · Cited by 3,794 · see citing works

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’Shea, K. S., Powell-Braxton, L., Hillan, K. J., & Moore, M. W. (1996) · Nature · doi:10.1038/380439a0 · Cited by 3,624 · see citing works

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., & Ferrara, N. (1993) · Nature · doi:10.1038/362841a0 · Cited by 3,605 · see citing works

Transplacental Carcinogenesis by Stilbestrol

Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197108122850711 · Cited by 2,640 · see citing works

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.

Soker, S., Takashima, S., Miao, H., Neufeld, G., & Klagsbrun, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81402-6 · Cited by 2,634 · see citing works

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502 · see citing works

Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization

Takahashi, T., Kalka, C., Masuda, H., Chen, D., Silver, M., Kearney, M., Magner, M., Isner, J. M., & Asahara, T. (1999) · Nature Medicine · doi:10.1038/7434 · Cited by 2,421 · see citing works

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

Gerber, H. P., Vu, T. H., Ryan, A. M., Kowalski, J., Werb, Z., & Ferrara, N. (1999) · Nature Medicine · doi:10.1038/9467 · Cited by 2,089 · see citing works

Evidence for Circulating Bone Marrow-Derived Endothelial Cells

Shi, Q., Rafii, S., Wu, M. H.-D., Wijelath, E. S., Yu, C., Ishida, A., Fujita, Y., Kothari, S., Möhle, R., Sauvage, L. R., et al. (1998) · Blood · doi:10.1182/blood.v92.2.362 · Cited by 1,694 · see citing works

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

Wang, H. U., Chen, Z., & Anderson, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81436-1 · Cited by 1,678 · see citing works

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

Presta, L. G., Chen, H., O'Connor, S. J., Chisholm, V., Meng, Y. G., KRUMMEN, L. A., Winkler, M., & Ferrara, N. (1997) · PubMed · Cited by 1,602 · see citing works

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

Carmeliet, P., Lampugnani, M. G., Moons, L., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Spagnuolo, R., Oosthuyse, B., Dewerchin, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81010-7 · Cited by 1,284 · see citing works

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

Jeltsch, M., Kaipainen, A., Joukov, V., Meng, X., Lakso, M., Rauvala, H., Swartz, M. A., Fukumura, D., Jain, R. K., & Alitalo, K. K. (1997) · Science · doi:10.1126/science.276.5317.1423 · Cited by 1,279 · see citing works

A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF

Benjamin, L. E., Hemo, I., & Keshet, E. (1998) · Development · doi:10.1242/dev.125.9.1591 · Cited by 1,265 · see citing works

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

Aiello, L. P., Pierce, E. A., Foley, E. D., Takagi, H., Chen, H., Riddle, L. M., Ferrara, N., King, G. L., & Smith, L. E. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10457 · Cited by 1,258 · see citing works

Constitutive Expression of phVEGF 165 After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia

Baumgärtner, I., Pieczek, A., Manor, O., Blair, R. H., Kearney, M., Walsh, K., & Isner, J. M. (1998) · Circulation · doi:10.1161/01.cir.97.12.1114 · Cited by 1,098 · see citing works

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

Takeshita, S., Zheng, L., Brogi, E., Kearney, M., Pu, L. L. Q., Bunting, S., Ferrara, N., Symes, J. F., & Isner, J. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117018 · Cited by 1,038 · see citing works

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesisPreprint

Adams, R. H., Wilkinson, G. A., Weiss, C., Diella, F., Gale, N. W., Deutsch, U., Risau, W., & Klein, R. (1999) · Genes & Development · doi:10.1101/gad.13.3.295 · Cited by 1,024 · see citing works

Tumor Induction of VEGF Promoter Activity in Stromal Cells

Fukumura, D., Xavier, R., Sugiura, T., Chen, Y., Park, E.-C., Lu, N., Selig, M., Nielsen, G., Taksir, T., Jain, R. K., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81731-6 · Cited by 996 · see citing works

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

Isner, J. M., Pieczek, A., Schainfeld, R. M., Blair, R. H., Haley, L. L., Asahara, T., Rosenfield, K., Razvi, S., Walsh, K., & Symes, J. F. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03361-2 · Cited by 990 · see citing works

Gene Therapy for Myocardial Angiogenesis

Losordo, D. W., Vale, P. R., Symes, J. F., Dunnington, C. H., Esakof, D. D., Maysky, M., Ashare, A. B., Lathi, K. G., & Isner, J. M. (1998) · Circulation · doi:10.1161/01.cir.98.25.2800 · Cited by 988 · see citing works

VEGF is required for growth and survival in neonatal mice

Gerber, H., Hillan, K. J., Ryan, A. M., Kowalski, J., Keller, G.-A., Rangell, L. K., Wright, B. D., Radtke, F., Aguet, M., & Ferrara, N. (1999) · Development · doi:10.1242/dev.126.6.1149 · Cited by 913 · see citing works

Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to Angiogenesis

Seghezzi, G., Patel, S., Ren, C. J., Gualandris, A., Pintucci, G., Robbins, E., Shapiro, R., Galloway, A., Rifkin, D., & Mignatti, P. (1998) · Journal of Cell Biology · doi:10.1083/jcb.141.7.1659 · Cited by 887 · see citing works

G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator

Bais, C., Santomasso, B., Coso, O. A., Arvanitakis, L., Geras‐Raaka, E., Gutkind, J. S., Asch, A. S., Cesarman, E., Gerhengorn, M. C., & Mesri, E. A. (1998) · Nature · doi:10.1038/34193 · Cited by 829 · see citing works

Increased Vascularization in Mice Overexpressing Angiopoietin-1

Suri, C., McClain, J., Thurston, G., McDonald, D. M., Zhou, H., Oldmixon, E. H., Sato, T. N., & Yancopoulos, G. D. (1998) · Science · doi:10.1126/science.282.5388.468 · Cited by 818 · see citing works

2′-Fluoropyrimidine RNA-based Aptamers to the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF165)

Ruckman, J., Green, L. S., Beeson, J., Waugh, S. M., Gillette, W. L., Henninger, D. D., Claesson, L., & Janjić, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20556 · Cited by 744 · see citing works

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

Yuan, F., Chen, Y., Dellian, M., Safabakhsh, N., Ferrara, N., & Jain, R. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14765 · Cited by 719 · see citing works

Tie2 Receptor Ligands, Angiopoietin-1 and Angiopoietin-2, Modulate VEGF-Induced Postnatal Neovascularization

Asahara, T., Chen, D., Takahashi, T., Fujikawa, K., Kearney, M., Magner, M., Yancopoulos, G. D., & Isner, J. M. (1998) · Circulation Research · doi:10.1161/01.res.83.3.233 · Cited by 683 · see citing works

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

Carmeliet, P., Ng, Y., Nuyens, D., Theilmeier, G., Brusselmans, K., Cornelissen, I., Ehler, E., Kakkar, V. V., Stalmans, I., Mattot, V., et al. (1999) · Nature Medicine · doi:10.1038/8379 · Cited by 679 · see citing works

Inhibition of Vascular Endothelial Growth Factor Prevents Retinal Ischemia—Associated Iris Neovascularization in a Nonhuman Primate

Adamis, A. P. (1996) · Archives of Ophthalmology · doi:10.1001/archopht.1996.01100130062010 · Cited by 630 · see citing works

Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor‐2

Soldi, R., Mitola, S. M. F., Strasly, M., Defilippi, P., Tarone, G., & Bussolino, F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.4.882 · Cited by 627 · see citing works

Vascular endothelial growth factor is essential for corpus luteum angiogenesis

Ferrara, N., Chen, H., Davis-Smyth, T., Gerber, H. P., Nguyen, T.-N., Peers, D. H., Chisholm, V., Hillan, K. J., & SCHWALL, R. H. (1998) · Nature Medicine · doi:10.1038/nm0398-336 · Cited by 624 · see citing works

Synergistic Effect of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor on Angiogenesis In Vivo

Asahara, T., Bauters, C., Zheng, L. P., Takeshita, S., Bunting, S., Ferrara, N., Symes, J. F., & Isner, J. M. (1995) · Circulation · doi:10.1161/01.cir.92.9.365 · Cited by 597 · see citing works

Transdifferentiated Retinal Pigment Epithelial Cells are Immunoreactive for Vascular Endothelial Growth Factor in Surgically Excised AgeRelated Macular Degeneration-Related Choroidal Neovascular Membranes.

Lopez, P. F., Sippy, B., Lambert, H. M., Thach, A. B., & Hinton, D. R. (1998) · Retina · doi:10.1097/00006982-199805000-00035 · Cited by 592 · see citing works

Local Delivery of Vascular Endothelial Growth Factor Accelerates Reendothelialization and Attenuates Intimal Hyperplasia in Balloon-Injured Rat Carotid Artery

Asahara, T., Bauters, C., Pastore, C., et al. (1995) · Circulation · doi:10.1161/01.cir.91.11.2793 · Cited by 547 · see citing works

A novel vascular endothelial growth factor encoded by Orf virus, VEGF‐E, mediates angiogenesis via signalling through VEGFR‐2 (KDR) but not VEGFR‐1 (Flt‐1) receptor tyrosine kinases

Meyer, M., Clauss, M. A., Lepple‐Wienhues, A., Waltenberger, J. L., Augustin, H. G., Ziche, M., Lanz, C., Büttner, M., Rziha, H., & Dehio, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.2.363 · Cited by 502 · see citing works

VEGF and VEGF-C: Specific Induction of Angiogenesis and Lymphangiogenesis in the Differentiated Avian Chorioallantoic Membrane

Oh, S.-J., Jeltsch, M., Birkenhäger, R., McCarthy, J. E. G., Weich, H. A., Christ, B., Alitalo, K. K., & Wilting, J. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8639 · Cited by 496 · see citing works

Prognostic Significance of Vascular Endothelial Growth Factor Protein in Node-Negative Breast Carcinoma

Gasparini, G. M., Bonoldi, E., Gatti, C., Vinante, O., Toi, M., Tominaga, T., Gion, M., Dittadi, R., Verderio, P., Boracchi, P., et al. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.2.139 · Cited by 492 · see citing works

Intracoronary gene transfer of fibroblast growth factor–5 increases blood flow and contractile function in an ischemic region of the heart

Giordano, F. J., Ping, P., McKirnan, M. D., et al. (1996) · Nature Medicine · doi:10.1038/nm0596-534 · Cited by 487 · see citing works

KDR Receptor: A Key Marker Defining Hematopoietic Stem Cells

ZIEGLER, B. L., Valtieri, M., Almeida-Porada, G. D., Maria, R. D., Müller, R., Masella, B., Gabbianelli, M., Casella, I., Pelosi, E., Bock, T. A., et al. (1999) · Science · doi:10.1126/science.285.5433.1553 · Cited by 487 · see citing works

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

Uyttendaele, H., Marazzi, G., Wu, G., Yan, Q., Sassoon, D. A., & Kitajewski, J. (1996) · Development · doi:10.1242/dev.122.7.2251 · Cited by 485 · see citing works

Vasculae Reactions of Normal and Malignant Tissues in Vivo. I. Vascular Reactions of Mice to Wounds and to Normal and Neoplastic Transplants

Algire, G. H., Chalkley, H. W., Legallais, F. Y., & Park, H. D. (1945) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/6.1.73 · Cited by 472 · see citing works

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins

Aliello, L. P. (1995) · Medical Entomology and Zoology · Cited by 463 · see citing works

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

van Bruggen, N., Thibodeaux, H., Palmer, J. T., Lee, W. P., Fu, L., Cairns, B., Tumas, D. B., Gerlai, R. T., Williams, S., Campagne, M. V. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8218 · Cited by 457 · see citing works

Potentiated Angiogenic Effect of Scatter Factor/Hepatocyte Growth Factor via Induction of Vascular Endothelial Growth Factor

BELLE, E. V., Witzenbichler, B., Chen, D., Silver, M., Chang, L., SCHWALL, R. H., & Isner, J. M. (1998) · Circulation · doi:10.1161/01.cir.97.4.381 · Cited by 446 · see citing works

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

Goldman, C. K., Kendall, R. L., Cabrera, G., Soroceanu, L., Heike, Y., Gillespie, G. Y., Siegal, G. P., Mao, X., Bett, A. J., Huckle, W. R., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8795 · Cited by 443 · see citing works

Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

Millauer, B., Longhi, M. P., Plate, K. H., Shawver, L. K., Risau, W., Ullrich, A., & Strawn, L. M. (1996) · PubMed · Cited by 413 · see citing works

A Novel Type of Vascular Endothelial Growth Factor, VEGF-E (NZ-7 VEGF), Preferentially Utilizes KDR/Flk-1 Receptor and Carries a Potent Mitotic Activity without Heparin-binding Domain

Ogawa, S., Oku, A., Sakaue-Sawano, A., Yamaguchi, S., Yazaki, Y., & Shibuya, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31273 · Cited by 405 · see citing works

Essential Role of Growth Hormone in Ischemia-Induced Retinal Neovascularization

Smith, L. E. H., Kopchick, J. J., Chen, W., Knapp, J., Kinose, F., Daley, D., Foley, E., Smith, R. G., & Schaeffer, J. M. (1997) · Science · doi:10.1126/science.276.5319.1706 · Cited by 392 · see citing works

Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results

Isner, J. M., Baumgärtner, I., Rauh, G., Schainfeld, R. M., Blair, R. H., Manor, O., Razvi, S., & Symes, J. F. (1998) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(98)70022-9 · Cited by 387 · see citing works

The angiogenesis induced by HIV–1 Tat protein is mediated by the Flk–1/KDR receptor on vascular endothelial cells

Albini, A., Soldi, R., Giunciuclio, D., Giraudo, E., Benelli, R., Primo, L., Noonan, D. M., Salio, M., Camussi, G., Rock, W., et al. (1996) · Nature Medicine · doi:10.1038/nm1296-1371 · Cited by 380 · see citing works

Vascular endothelial growth factor as capillary permeability agent in ovarian hyperstimulation syndrome

McClure, N., Healy, D. L., Rogers, P. A. W., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)93001-5 · Cited by 375 · see citing works

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

Lin, P. C., Buxton, J. A., Acheson, A. L., Radziejewski, C. H., Maisonpierre, P. C., Yancopoulos, G. D., Channon, K. M., Hale, L. P., Dewhirst, M. W., George, S. E., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8829 · Cited by 371 · see citing works

VEGF Gene Delivery to Muscle

Springer, M. L., Chen, A. S., Kraft, P. E., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80154-9 · Cited by 365 · see citing works

Vascular Endothelial Growth Factor-C (VEGF-C/VEGF-2) Promotes Angiogenesis in the Setting of Tissue Ischemia

Witzenbichler, B., Asahara, T., Murohara, T., Silver, M., Spyridopoulos, I., Magner, M., Principe, N., Kearney, M., Hu, J., & Isner, J. M. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65582-4 · Cited by 344 · see citing works

VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis

Li, J., Brown, L. F., Hibberd, M. G., Grossman, J. D., Morgan, J. P., & Simons, M. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.5.h1803 · Cited by 340 · see citing works

Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy.

Borgström, P., Hillan, K. J., Sriramarao, P., & Ferrara, N. (1996) · PubMed · Cited by 331 · see citing works

Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis

Pearlman, J. D., Hibberd, M. G., Chuang, M. L., et al. (1995) · Nature Medicine · doi:10.1038/nm1095-1085 · Cited by 327 · see citing works

Flk-1 as a target for tumor growth inhibition.

Strawn, L. M., McMahon, G., App, H., Schreck, R., Kuchler, W. R., Longhi, M. P., Hui, T. H., Tang, C., Levitzki, A., Gazit, A., et al. (1996) · PubMed · Cited by 317 · see citing works

Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart

Mack, C. A., Patel, S. R., Schwarz, E. A., et al. (1998) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(98)70455-6 · Cited by 308 · see citing works

Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts.

Harada, K., Grossman, W., Friedman, M., et al. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117378 · Cited by 304 · see citing works

VEGF165 mediates glomerular endothelial repair

Ostendorf, T., Kunter, U., Eitner, F., Loos, A., Regele, H. M., Kerjaschki, D., Henninger, D. D., Janjić, N., & Floege, J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6740 · Cited by 286 · see citing works

Hereditary lymphedema: evidence for linkage and genetic heterogeneity

Ferrell, R. E. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.13.2073 · Cited by 284 · see citing works

Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1

Wise, L. M., Veikkola, T., Mercer, A. A., Savory, L. J., Fleming, S. B., Caesar, C., Vitali, A. A., Mäkinen, T., Alitalo, K. K., & Stacker, S. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3071 · Cited by 272 · see citing works

High pre-treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer

Salvén, P., Ruotsalainen, T. M., Mattson, K., & Joensuu, H. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980417)79:2 · Cited by 261 · see citing works

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.

Lin, P., Polverini, P. J., Dewhirst, M. W., Shan, S., Rao, P. S., & Peters, K. G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119740 · Cited by 252 · see citing works

Advances in Coronary Angioplasty

Bittl, J. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610243351707 · Cited by 233 · see citing works

Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.

Takeshita, S., Tsurumi, Y., Couffinahl, T., et al. (1996) · PubMed · Cited by 212 · see citing works

Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector

Greelish, J. P., Su, L. T., Lankford, E. B., Burkman, J. M., Chen, H., Koenig, S., Mercier, I. M., Desjardins, P. R., Mitchell, M. A., Zheng, X. G., et al. (1999) · Nature Medicine · doi:10.1038/7439 · Cited by 211 · see citing works

Magnetic Resonance Imaging Detects Suppression of Tumor Vascular Permeability After Administration of Antibody to Vascular Endothelial Growth Factor

Pham, C. D., Roberts, T. P. L., van Bruggen, N., Melnyk, O. O., Mann, J. S., Ferrara, N., Cohen, R. L., & Brasch, R. C. (1998) · Cancer Investigation · doi:10.3109/07357909809039771 · Cited by 208 · see citing works

Preclinical Safety Evaluation of rhuMAbVEGF, an Antiangiogenic Humanized Monoclonal Antibody

Ryan, A. M., Eppler, D. B., Hagler, K. E., Bruner, R. H., Thomford, P. J., Hall, R. L., Shopp, G. M., & O’neill, C. A. (1999) · Toxicologic Pathology · doi:10.1177/019262339902700115 · Cited by 202 · see citing works

VEGF Gene Transfer Reduces Intimal Thickening via Increased Production of Nitric Oxide in Carotid Arteries

Laitinen, M., Zachary, I. C., Breier, G., et al. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.15-1737 · Cited by 198 · see citing works

Adenovirus-Mediated Gene Transfer to Lower Limb Artery of Patients with Chronic Critical Leg Ischemia

Laitinen, M., Mäkinen, K., Manninen, H. I., Matsi, P. J., Kossila, M., Agrawal, R. S., Pakkanen, T. M., Luoma, J. S., Viita, H., Hartikainen, J. E. K., et al. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.10-1481 · Cited by 198 · see citing works

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