The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin‐1
Abstract
Aquaporin‐1 (AQP1) is a water channel expressed strongly at the ventricular‐facing surface of choroid plexus epithelium. We developed novel methods to compare water permeability in isolated choroid plexus of wild‐type vs. AQP1 null mice, as well as intracranial pressure (ICP) and cerebrospinal fluid (CSF) production and absorption. Osmotically induced water transport was rapid in choroid plexus from wild‐type mice and reduced by fivefold by AQP1 deletion. AQP1 deletion did not affect choroid plexus size or structure. By stereotaxic puncture of the lateral ventricle with a microneedle, ICP was 9.5 ± 1.4 cm H 2 O in wild‐type mice and 4.2 ± 0.4 cm H 2 O in AQP1 null mice. CSF production, an isosmolar fluid secretion process, was measured by a dye dilution method involving fluid collections using a second microneedle introduced into the cisterna magna. CSF production in wild‐type mice was (in µl min –1 ) 0.37 ± 0.04 (control), 0.16 ± 0.03 (acetazolamide‐treated), and 1.14 ± 0.15 (forskolin‐treated), and reduced by ~25% in AQP1 null mice. Pressure‐dependent CSF outflow, measured from steady‐state ICP at different ventricular infusion rates, was not affected by AQP1 deletion. In a model of focal brain injury, AQP1 null mice had remarkably reduced ICP and improved survival compared with wild‐type mice. The reduced ICP and CSF production in AQP1 null mice provides direct functional evidence for the involvement of AQP1 in CSF dynamics, suggesting AQP1 inhibition as a novel option for therapy of elevated ICP.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
Manley, G. T., Fujimura, M., Ma, T., Noshita, N., Filiz, F., Bollen, A. W., Chan, P., & Verkman, A. S. (2000) · Nature Medicine · doi:10.1038/72256 · Cited by 1,507
Self-citationAquaporin water channels – from atomic structure to clinical medicine
Agre, P., King, L. S., Yasui, M., Guggino, W. B., Ottersen, O. P., Fujiyoshi, Y., Engel, A., & Nielsen, S. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.020818 · Cited by 1,139
Preston, G. M., & Agre, P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11110 · Cited by 816
Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia.
Nielsen, S., Smith, B. L., Christensen, E. I., & Agre, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7275 · Cited by 781
Guidelines for the management of severe head injury
BULLOCK, R., CHESNUT, R. M., CLIFTON, G., GHAJAR, J., MARION, D. W., NARAYAN, R. K., NEWELL, D. W., PITTS, L. H., ROSNER, M. J., & WILBERGER, J. W. (1996) · European Journal of Emergency Medicine · doi:10.1097/00063110-199606000-00010 · Cited by 684
A nonlinear analysis of the cerebrospinal fluid system and intracranial pressure dynamics
Marmarou, A., Shulman, K., & Rosende, R. M. (1978) · Journal of Neurosurgery · doi:10.3171/jns.1978.48.3.0332 · Cited by 586
Ma, T., Yang, B., Gillespie, A., Carlson, E. J., Epstein, C. J., & Verkman, A. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4296 · Cited by 564
Self-citationDefective Secretion of Saliva in Transgenic Mice Lacking Aquaporin-5 Water Channels
Ma, T., Song, Y., Gillespie, A., Carlson, E. J., Epstein, C. J., & Verkman, A. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20071 · Cited by 547
Self-citationAquaporins in Brain: Distribution, Physiology, and Pathophysiology
Badaut, J., Lasbennes, F., Magistretti, P. J., & Regli, L. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200204000-00001 · Cited by 541
Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice
Schnermann, J., Chou, C.-L., Ma, T., Traynor, T., Knepper, M. A., & Verkman, A. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9660 · Cited by 451
Self-citation
Cited by
The glymphatic system: a beginner's guide
Jessen, N. A., Munk, A. S. F., Lundgaard, I., & Nedergaard, M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1581-6 · Cited by 2,075
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Louveau, A., Herz, J., Alme, M. N., Salvador, A. F., Dong, M. Q., Viar, K. E., Herod, S. G., Knopp, J., Setliff, J. C., Lupi, A. L., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0227-9 · Cited by 956
Multiplicity of cerebrospinal fluid functions: new challenges in health and disease
Johanson, C. E., Duncan, J. A., Klinge, P. M., Brinker, T., Stopa, E. G., & Silverberg, G. D. (2008) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-5-10 · Cited by 861
Cerebrospinal fluid secretion by the choroid plexus
Damkier, H. H., Brown, P. D., & Praetorius, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2013 · Cited by 606
Aquaporins: important but elusive drug targets
Verkman, A. S., Anderson, M. O., & Papadopoulos, M. C. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4226 · Cited by 586
Self-citation
Metadata
- Authors
- Oshio, K., Watanabe, H., Song, Y., Verkman, A. S., & Manley, G. T.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2004-11-08
- Volume
- 19
- Issue
- 1
- Pages
- 76-78
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2092193387
- Cited by
- 473
- References
- 37
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin‐1. https://app.cochat.ai/papers/10.1096/fj.04-1711fje
- The paper
- Oshio, K., Watanabe, H., Song, Y., Verkman, A. S., & Manley, G. T. (2005). Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin‐1. The FASEB Journal. https://doi.org/10.1096/fj.04-1711fje
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
