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Protective Role of Myelocytic Nitric Oxide Synthases against Hypoxic Pulmonary Hypertension in Mice

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Plasma l-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction

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Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB

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GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease

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Overexpression of cationic amino acid transporter‐1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells

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Protein expression by human pulmonary artery smooth muscle cells containing a BMPR2 mutation and the action of ET-1 as determined by proteomic mass spectrometry

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Therapeutics Targeting of Dysregulated Redox Equilibrium and Endothelial Dysfunction

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Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure

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Absence of the calcium-binding protein, S100A1, confers pulmonary hypertension in mice associated with endothelial dysfunction and apoptosis

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Nitric oxide and mitochondrial function in cardiovascular diseases

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Update on novel targets and potential treatment avenues in pulmonary hypertension

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Connexin 43 Plays a Role in Pulmonary Vascular Reactivity in Mice

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Possible Involvement of Altered Arginase Activity, Arginase Type I and Type II Expressions, and Nitric Oxide Production in Occurrence of Intimal Hyperplasia in Premenopausal Human Uterine Arteries

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Updated perspective of EPAS1 and the role in pulmonary hypertension

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Arginase Inhibition by Ethylacetate Extract ofCaesalpinia sappanLignum Contributes to Activation of Endothelial Nitric Oxide Synthase

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Combination therapy for the treatment of pulmonary arterial hypertension

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Up-regulation of arginase II contributes to pulmonary vascular endothelial cell dysfunction during experimental pulmonary embolism

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Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow

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Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells

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AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery

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Exploring Endothelial Colony-Forming Cells to Better Understand the Pathophysiology of Disease: An Updated Review

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The Glycobiology of Pulmonary Arterial Hypertension

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Quantification of Multifunctional Dipeptide YA from Oyster Hydrolysate for Quality Control and Efficacy Evaluation

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Novel Prognostic Predictor for Primary Pulmonary Hypertension: Focus on Blood Urea Nitrogen

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An arginase-1 SNP that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia enhances NO-mediated apoptosis in lymphocytes

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Hyperoxia increases hepatic arginase expression and ornithine production in mice

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TP508 (Chrysalin ® ) Reverses Endothelial Dysfunction and Increases Perfusion and Myocardial Function in Hearts With Chronic Ischemia

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Echocardiographic Pulmonary Hypertension Predicts Post-transplantation Renal Allograft Failure

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NO‐sensitive guanylyl cyclase in the lung

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Nδ-Methylated l-arginine derivatives and their effects on the nitric oxide generating system

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Signal transduction and oxidative processes in sinonasal polyposis

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Pulmonary Hypertension in Thalassemia: Association with Hemolysis, Arginine Metabolism Dysregulation, and a Hypercoagulable State

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Inflammatory Mechanisms in the Pathogenesis of Pulmonary Arterial Hypertension

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Possible involvement of enhanced arginase activity due to up-regulated arginases and decreased hydroxyarginine in accelerating intimal hyperplasia with hyperglycemia

Ishizaka, M., Nagai, A., Iwanaga, M., Imamura, M., & Azuma, H. (2007) · Vascular Pharmacology · doi:10.1016/j.vph.2007.08.001 · Cited by 14

MicroRNA in pulmonary vascular disease.

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Arginase Promotes Skeletal Muscle Arteriolar Endothelial Dysfunction in Diabetic Rats

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Arginase inhibition protects against hypoxia-induced pulmonary arterial hypertension

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L-arginine plasma levels and severity of idiopathic pulmonary arterial hypertension

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Chronic hypercapnia downregulates arginase expression and activity and increases pulmonary arterial smooth muscle relaxation in the newborn rat

Belik, J., Stevens, D. R., Pan, J., Shehnaz, D., Ibrahim, C., Kantores, C., Ivanovska, J., Grasemann, H., & Jankov, R. P. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00047.2009 · Cited by 13

Metabolomic fingerprint of coronary blood in STEMI patients depends on the ischemic time and inflammatory state

Deidda, M., Piras, C., Binaghi, G., Congia, D., Pani, A., Boi, A., Sanna, F., Rossi, A., Loi, B., Dessalvi, C. C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-36415-y · Cited by 13

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Is pulmonary vascular disease reversible with PPAR ɣ agonists?

Afdal, P., & AbdelMassih, A. F. (2018) · Microcirculation · doi:10.1111/micc.12444 · Cited by 12

Is arginase a potential drug target in tobacco-induced pulmonary endothelial dysfunction?

Henno, P., Maurey, C., Pimpec‐Barthes, F. L., Devillier, P., Delclaux, C., & Israël‐Biet, D. (2015) · Respiratory Research · doi:10.1186/s12931-015-0196-4 · Cited by 12

Pulmonary Hypertension: Evaluation and Management

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Rho-Kinase Inhibitors

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Human-based evidence for the therapeutic potential of arginase inhibitors in cardiovascular diseases

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Upregulation of Arginase Expression and Activity in Hypertensive Rats Exposed to Chronic Intermittent Hypobaric Hypoxia

López, V., Siqués, P., Brito, J., Vallejos, C., Naveas, N., Carvallo, C., Lèon‐Velarde, F., & Carvajal, N. (2009) · High Altitude Medicine & Biology · doi:10.1089/ham.2008.1072 · Cited by 11

Pathways to pulmonary hypertension in sickle cell disease: the search for prevention and early intervention

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Measuring exhaled nitric oxide in COPD: from theoretical consideration to practical views

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CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury

Li, C., Ajmal, E., Alok, K., Powell, K., Wadolowski, S., Tambo, W., Turpin, J., Barthélemy, E. J., Al‐Abed, Y., & LeDoux, D. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00619-x · Cited by 12

Problems of High Altitude Medicine and Biology

Aldashev, A. A., & Naeije, R. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6300-8 · Cited by 10

Concealed role of red blood cells in pathogenesis of pulmonary arterial hypertension: Decreased red blood cell nitric oxide generation and effect of Rho-Kinase inhibitor fasudil

Başarıcı, İ., Özen, N., Kilavuz, E., Kısak, F., Basralı, F., Yaraş, N., Köksoy, S., Çelik, M. L., & Ülker, P. (2020) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-200892 · Cited by 10

Diet, herbs and erectile function: A good friendship!

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Indian Women of Childbearing Age Do Not Metabolically Conserve Arginine as Do American and Jamaican Women ,

Kao, C. C., Hsu, J. W.-C., Dwarkanath, P., Karnes, J. M., Baker, T. M., Bohren, K. M., Badaloo, A. V., Thame, M. M., Kurpad, A. V., & Jahoor, F. (2015) · Journal of Nutrition · doi:10.3945/jn.114.208231 · Cited by 10

The hyperproliferative endothelial cell phenotype in idiopathic pulmonary arterial hypertension

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Salidroside enhances NO bioavailability and modulates arginine metabolism to alleviate pulmonary arterial hypertension

Li, J., Zhang, Z., Zhu, C., Zheng, X., Wang, C., Jiang, J., & Zhang, H. (2024) · European journal of medical research · doi:10.1186/s40001-024-02016-x · Cited by 9

Vascular Metabolic Mechanisms of Pulmonary Hypertension

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Asymmetric dimethylarginine does not inhibit arginase activity and is pro‐proliferative in pulmonary endothelial cells

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Semen, K. O., & Bast, A. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2018.12.087 · Cited by 9

PDE9A deficiency does not prevent chronic‐hypoxic pulmonary hypertension in mice

Kolb, T. M., Johnston, L., Damarla, M., Kass, D. A., & Hassoun, P. M. (2021) · Physiological Reports · doi:10.14814/phy2.15057 · Cited by 9

Impact of l ‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells

Douglass, M. S., Kaplowitz, M. R., Zhang, Y., & Fike, C. D. (2023) · Pulmonary Circulation · doi:10.1002/pul2.12221 · Cited by 8

Role of Arginase in Sickle Cell Lung Disease and Hemolytic Anemias~!2009-11-12~!2010-03-16~!2010-05-04~!

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Folic acid, either solely or combined with L‐citrulline, improves NO signaling and ameliorates chronic hypoxia‐induced pulmonary hypertension in newborn pigs

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Uncoupling of Endothelial Nitric Oxide Synthase in Cardiovascular Disease and its Pharmacological Reversal

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Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous l -arginine

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Plasma nitrite/nitrate levels: a new biomarker for pulmonary arterial hypertension?

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Induction of Arginase II mRNA by Nitric Oxide Using an In Vitro Model of Gyrate Atrophy of Choroid and Retina

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