The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
Aβ peptide immunization restores blood‐brain barrier integrity in Alzheimer disease
Abstract
Immunization with amyloid beta (Abeta) peptides or passive immunization with antibodies against Abeta has been reported to reduce plaque burden, neuritic dystrophy, early Tau pathology, microgliosis as well as reversing learning and memory deficits. This has created a central paradox: how does vaccination in peripheral tissues reduce plaque burden in the brain? No single explanation for these phenomena has yet been presented. To reconcile these observations, we demonstrate that the integrity of the blood-brain barrier (BBB), a structural barrier between the brain and the blood, is compromised in Tg2576 Alzheimer disease (AD) model mice. We immunized Tg2576 mice with Abeta before and after the onset of AD-type neuropathology and observed that BBB permeability, amyloid burden, and microgliosis are decreased in immunized mice. It is concluded that the integrity of the BBB is disrupted in AD mice, and after Abeta immunization the immune system clears Abeta from sources in the brain as it would in peripheral organs lacking barriers. Once Abeta is removed, the integrity of the BBB is restored. The data therefore provide an intellectual framework for understanding how the immune system can clear amyloid deposits from AD brains and suggest new strategies for limiting disease progression in amyloidopathies.
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“impairments of the BBB have been observed in this context (Dickstein et al., 2006; Zipser et al., 2007; Lassman et al., 2012; Figure 2).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Dickstein et al., 2006
In the citing paper
“It has already been shown that the elimination of Aβ from the brain and the consequent impairment of microglial activation decrease ROS, nitrogen compounds and also inflammatory cytokines produced by microglial cells, which are correlated with the activation of ECs (Dickstein et al., 2006).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Dickstein et al., 2006
Citations
Cites
Inflammation and Alzheimer’s disease
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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
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F4/80, a monoclonal antibody directed specifically against the mouse macrophage
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Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,506
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431
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Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
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The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization
Hamley, I. W. (2012) · Chemical Reviews · doi:10.1021/cr3000994 · Cited by 892
Apolipoprotein E in Alzheimer’s disease and other neurological disorders
Verghese, P. B., Castellano, J. M., & Holtzman, D. M. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70325-2 · Cited by 857
The impact of microglial activation on blood-brain barrier in brain diseases
da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572
“…during inflammatory response probably disrupts BBB integrity by redistribution of tight junction proteins, such as occludin and claudin-1, 5 and 11 and reorganization of the actin cytoskeleton in brain microvascular ECs (Stamatovic et al., 2003, 2005, 2006; Dimitrijevic et al., 2006).”
BackgroundBlood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy
Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B. (2007) · Cell Transplantation · doi:10.3727/000000007783464731 · Cited by 339
Kanoski, S. E., Zhang, Y., Zheng, W., & Davidson, T. L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091414 · Cited by 324
“Furthermore, BBB breakdown in a transgenic mouse model of AD can be reversed by Aβ immunization [44].”
Metadata
- Authors
- Dickstein, D. L., Biron, K. E., Ujiie, M., Pfeifer, C. G., Jeffries, A. R., & Jefferies, W. A.
- Affiliations
- University of British Columbia (CA)
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2006-03
- Volume
- 20
- Issue
- 3
- Pages
- 426-433
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2021255508
- Cited by
- 111
- References
- 52
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 9 · 2013: 5 · 2012: 4
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Update notices
- erratum (2006-07-01)
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta immunization, blood-brain barrier integrity, Alzheimer's disease, Tg2576 mice, blood-brain barrier permeability, amyloid plaque clearance, microglial activation, amyloid pathology, neuroinflammation
- MeSH terms
- Alzheimer Disease, Animals, Antibodies, Blood-Brain Barrier, Disease Models, Animal, Female, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Organ Specificity, Peptide Fragments, Vaccination, Amyloid beta-Peptides, Microglia, Mice, Plaque, Amyloid
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