The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc min mice
Open accessAbstract
Sulforaphane (SFN) is an isothiocyanate from broccoli that induces phase 2 detoxification enzymes. We recently reported that SFN acts as a histone deacetylase (HDAC) inhibitor in human colon cancer cells in vitro, and the present study sought to extend these findings in vivo. In mice treated with a single oral dose of 10 ümol SFN, there was significant inhibition of HDAC activity in the colonic mucosa after 6 h, and immunoblots revealed a concomitant increase in acetylated histones H3 and H4, which returned to control levels by 48 h. Longer‐term treatment with SFN in the diet resulted in levels of acetylated histones and p21 WAF1 in the ileum, colon, prostate, and peripheral blood mononuclear cells that were elevated compared with controls. Consistent with these findings, SFN suppressed tumor development in Apc min mice, and there was an increase in acetylated histones in the polyps, including acetylated histones specifically associated with the promoter region of the P21 and bax genes. These results provide the first evidence for HDAC inhibition by SFN in vivo and imply that such a mechanism might contribute to the cancer chemoprotective and therapeutic effects of SFN, alone or in combination with other HDAC inhibitors currently undergoing clinical trials.
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Nrf2, a multi‐organ protector?
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Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis
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Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
HIGDON, J., DELAGE, B., WILLIAMS, D., & DASHWOOD, R. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.009 · Cited by 1,039
Self-citationHistone deacetylases and cancer
Glozak, M. A., & Seto, E. (2007) · Oncogene · doi:10.1038/sj.onc.1210610 · Cited by 1,031
Dietary histone deacetylase inhibitors: From cells to mice to man
DASHWOOD, R., & HO, E. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.04.001 · Cited by 296
Self-citationIndividuality and epigenetics in obesity
Campión, J., Milagro, F. I., & Martínez, J. A. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00595.x · Cited by 275
KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V., & Kensler, T. W. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.02.002 · Cited by 273
Metadata
- Authors
- Myzak, M. C., Dashwood, W. M., Orner, G. A., Ho, E., & Dashwood, R. H.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2006-01-11
- Volume
- 20
- Issue
- 3
- Pages
- 506-508
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2128428442
- Cited by
- 344
- References
- 38
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- green
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