The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Individuality and epigenetics in obesity
Open accessAbstract
Summary: Excessive weight gain arises from the interactions among environmental factors, genetic predisposition and the individual behavior. However, it is becoming evident that interindividual differences in obesity susceptibility depend also on epigenetic factors. Epigenetics studies the heritable changes in gene expression that do not involve changes to the underlying DNA sequence. These processes include DNA methylation, covalent histone modifications, chromatin folding and, more recently described, the regulatory action of miRNAs and polycomb group complexes. In this review, we focus on experimental evidences concerning dietary factors influencing obesity development by epigenetic mechanisms, reporting treatment doses and durations. Moreover, we present a bioinformatic analysis of promoter regions for the search of future epigenetic biomarkers of obesity, including methylation pattern analyses of several obesity‐related genes (epiobesigenes), such as FGF2, PTEN, CDKN1A and ESR1, implicated in adipogenesis, SOCS1/SOCS3, in inflammation, and COX7A1 LPL, CAV1, and IGFBP3, in intermediate metabolism and insulin signalling. The identification of those individuals that at an early age could present changes in the methylation profiles of specific genes could help to predict their susceptibility to later develop obesity, which may allow to prevent and follow‐up its progress, as well as to research and develop newer therapeutic approaches.
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Citations
Cites
1 retracted
Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes
Jiang, Y., Jiang, J., Xiong, J., Cao, J., Li, N., Li, G., & Wang, S. (2008) · Journal of Experimental Biology · doi:10.1242/jeb.012914 · Cited by 22
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“In this sense, maternal supraphysiological methyl group (folate, cobalamin, choline and betaine) supply (35), and a low-protein diet in rodents throughout pregnancy (36) modified DNA methylation of some key metabolic genes (agouti, glucocorticoid receptor and peroxisomal proliferator-activated receptoralpha).”
BackgroundInduction of tumors in mice by genomic hypomethylation
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BackgroundEpigenetic inheritance at the agouti locus in the mouse
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BackgroundNutritional Control of Reproductive Status in Honeybees via DNA Methylation
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Cited by
Han, J. C., Lawlor, D. A., & Kimm, S. Y. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60171-7 · Cited by 1,309
Alegría-Torres, J. A., Baccarelli, A., & Bollati, V. (2011) · Epigenomics · doi:10.2217/epi.11.22 · Cited by 587
Maternal environment and the transgenerational cycle of obesity and diabetes.
Dabelea, D., & Crume, T. (2011) · Diabetes · doi:10.2337/db11-0400 · Cited by 347
Cortessis, V. K., Thomas, D. C., Levine, A. J., Breton, C. V., Mack, T. M., Siegmund, K. D., Haile, R. W., & Laird, P. W. (2012) · Human Genetics · doi:10.1007/s00439-012-1189-8 · Cited by 319
The role of nutrition on epigenetic modifications and their implications on health
Jiménez-Chillarón, J. C., Díaz, R., Martínez, D., Pentinat, T., Ramón-Krauel, M., Ribó, S., & Plösch, T. (2012) · Biochimie · doi:10.1016/j.biochi.2012.06.012 · Cited by 266
Metadata
- Authors
- Campión, J., Milagro, F. I., & Martínez, J. A.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2009-06-25
- Volume
- 10
- Issue
- 4
- Pages
- 383-392
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W1974387660
- Cited by
- 275
- References
- 89
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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