The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597–624)
Open accessAbstract
Amyloid beta-peptide (Abeta) is postulated to play a central role in the pathogenesis of Alzheimer's disease. We recently proposed a pathway of Abeta-induced toxicity that is APP dependent and involves the facilitation of APP complex formation by Abeta. The APP-dependent component requires cleavage of APP at position 664 in the cytoplasmic domain, presumably by caspases or caspase-like proteases, with release of a potentially cytotoxic C31 peptide. In this study we show that Abeta interacted directly and specifically with membrane-bound APP to facilitate APP homo-oligomerization. Using chimeric APP molecules, this interaction was shown to take place between Abeta and its homologous sequence on APP. Consistent with this finding, we demonstrated that Abeta also facilitated the oligomerization of beta-secretase cleaved APP C-terminal fragment (C99). We found that the YENPTY domain in the APP cytoplasmic tail and contained within C31 is critical for this cell death pathway. Deletion or alanine- scanning mutagenesis through this domain significantly attenuated cell death apparently without affecting either APP dimerization or cleavage at position 664. This indicated that sequences within C31 are required after its release from APP. As the YENPTY domain has been shown to interact with a number of cytosolic adaptor molecules, it is possible that the interaction of APP, especially dimeric forms of APP, with these molecules contribute to cell death.
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“Remarkably, it was shown that extracellular Aβ1-42 was not toxic to APP knockout neurons [107] and that even point mutations in the NPXY motif in the C-terminus of APP block toxicity [169].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [169]
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Metadata
- Authors
- Shaked, G. M., Kummer, M. P., Lu, D. C., Galvan, V., Bredesen, D. E., Koo, E. H., Shaked, G. M., Kummer, M. P., Lu, D. C., Galvan, V., Bredesen, D. E., & Koo, E. H.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2006-04-24
- Volume
- 20
- Issue
- 8
- Pages
- 1254-1256
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- PMC
- PMC1847355
- OpenAlex
- W2108938583
- Cited by
- 132
- References
- 44
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 12 · 2016: 7 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 6
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AG05131)
- Alzheimer's Association
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta, Alzheimer's disease, APP, APP C-terminal fragments, caspase-like proteases, cell death
- MeSH terms
- Amino Acid Sequence, Animals, Membrane Proteins, Molecular Sequence Data, Peptide Fragments, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Cell Death, Protein Structure, Tertiary, Amino Acid Motifs, Cell Line, Tumor, Mice, Rats
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