The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease

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Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

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Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

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Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

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Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

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Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

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Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

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Amyloid, the presenilins and Alzheimer’s disease

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Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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Skeletal and CNS Defects in Presenilin-1-Deficient Mice

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Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

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Amyloid β-Protein and the Genetics of Alzheimer's Disease

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques

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Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease

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Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

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Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors

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The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

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Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).

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The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

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Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

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Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42

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Platelet Coagulation Factor XI a -Inhibitor, a Form of Alzheimer Amyloid Precursor Protein

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Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins

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The β-Amyloid Precursor Protein of Alzheimer’s Disease Enhances Neuron Viability and Modulates Neuronal Polarity

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Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons.

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Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 Expression

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The Carboxyl Termini of β-Amyloid Peptides 1-40 and 1-42 Are Generated by Distinct γ-Secretase Activities

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Subcellular Distribution and Turnover of Presenilins in Transfected Cells

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Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells

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An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos

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Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.

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Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites

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Alzheimer Amyloid Protein Precursor Is Localized in Nerve Terminal Preparations to Rab5-containing Vesicular Organelles Distinct from Those Implicated in the Synaptic Vesicle Pathway

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Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Aβ Production in Human Primary Neuron Cultures.

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Proteolytic Fragments of the Alzheimer's Disease Associated Presenilins-1 and -2 Are Phosphorylated in Vivo by Distinct Cellular Mechanisms

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Amyloid Precursor Protein Processing in Sterol Regulatory Element-binding Protein Site 2 Protease-deficient Chinese Hamster Ovary Cells

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Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

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Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

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A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

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GFAP in health and disease

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Intraneuronal Aβ42 Accumulation in Human Brain

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Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

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Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

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Neuropathology of Alzheimer's Disease

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Epigenetic mechanisms in memory formation

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Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease

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Role of the Reelin Signaling Pathway in Central Nervous System Development

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Metformin: An Old But Still the Best Treatment for Type 2 Diabetes

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Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice

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β-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal α7 Nicotinic Acetylcholine Receptors:<i>In Vitro</i>and<i>In Vivo</i>Mechanisms Related to Alzheimer's Disease

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Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons

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Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

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Emerging role of the cannabinoid receptor CB ₂ in immune regulation: therapeutic prospects for neuroinflammation

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Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer’s disease

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Antidiabetic drug metformin (Glucophage ^R ) increases biogenesis of Alzheimer's amyloid peptides via up-regulating <i>BACE1</i> transcription

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The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease

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Clearing amyloid through the blood-brain barrier

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Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

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Multifunctional Nanoliposomes with Curcumin-Lipid Derivative and Brain Targeting Functionality with Potential Applications for Alzheimer Disease

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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

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Critical role of endothelial Notch1 signaling in postnatal angiogenesis

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Accelerated Plaque Accumulation, Associative Learning Deficits, and Up-regulation of α7 Nicotinic Receptor Protein in Transgenic Mice Co-expressing Mutant Human Presenilin 1 and Amyloid Precursor Proteins

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Amyloid Angiopathy and Variability in Amyloid β Deposition Is Determined by Mutation Position in Presenilin-1-Linked Alzheimer’s Disease

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