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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

Gervais, François G., Xu, Daigen, Robertson, George S., Vaillancourt, John P., Zhu, Yanxia, Huang, JingQi, LeBlanc, Andréa, Smith, David, Rigby, Michael, Shearman, Mark S., Clarke, Earl E., Zheng, Hui, Van Der Ploeg, Leonardus H.T., Ruffolo, Salvatore C., Thornberry, Nancy A., Xanthoudakis, Steve, Zamboni, Robert J., Roy, Sophie, Nicholson, Donald W.·1999·Cell
DOI 10.1016/s0092-8674(00)80748-5
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Abstract

The amyloid-beta precursor protein (APP) is directly and efficiently cleaved by caspases during apoptosis, resulting in elevated amyloid-beta (A beta) peptide formation. The predominant site of caspase-mediated proteolysis is within the cytoplasmic tail of APP, and cleavage at this site occurs in hippocampal neurons in vivo following acute excitotoxic or ischemic brain injury. Caspase-3 is the predominant caspase involved in APP cleavage, consistent with its marked elevation in dying neurons of Alzheimer's disease brains and colocalization of its APP cleavage product with A beta in senile plaques. Caspases thus appear to play a dual role in proteolytic processing of APP and the resulting propensity for A beta peptide formation, as well as in the ultimate apoptotic death of neurons in Alzheimer's disease.

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Crossref · 10.1016/s0092-8674(00)80748-5

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Research works printed but not linked: 36

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Metadata

Authors
Gervais, F. G., Xu, D., Robertson, G. S., Vaillancourt, J. P., Zhu, Y., Huang, J., LeBlanc, A., Smith, D., Rigby, M., Shearman, M. S., Clarke, E. E., Zheng, H., Van Der Ploeg, L. H. T., Ruffolo, S. C., Thornberry, N. A., Xanthoudakis, S., Zamboni, R. J., Roy, S., & Nicholson, D. W.
Venue
Cell
Publisher
Elsevier BV
Published
1999-04
Volume
97
Issue
3
Pages
395-406
ISSN
0092-8674
DOI
10.1016/s0092-8674(00)80748-5
Cited by
674
References
5
Language
en
Licence

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